Zobrazeno 1 - 10
of 171
pro vyhledávání: '"Y. Eugene Chin"'
Autor:
Lijiang Wang, Supaporn Kulthinee, John Slate-Romano, Thomas Zhao, Hamsa Shanmugam, Patrycja M Dubielecka, Ling X. Zhang, Gangjian Qin, Shougang Zhuang, Y. Eugene Chin, Ting C. Zhao
Publikováno v:
Experimental and Molecular Pathology, Vol 134, Iss , Pp 104869- (2023)
Introduction: Irisin plays an important role in regulating tissue stress, cardiac function, and inflammation. Integrin αvβ5 was recently identified as a receptor for irisin to elicit its physiologic function. It remains unknown whether integrin αv
Externí odkaz:
https://doaj.org/article/9d752d63ef2849ea8271774bf38a64db
Autor:
Hongyong Song, Xiaofeng Ye, Yueling Liao, Siwei Zhang, Dongliang Xu, Shuangshuang Zhong, Bo Jing, Tong Wang, Beibei Sun, Jianhua Xu, Wenzheng Guo, Kaimi Li, Min Hu, Yanbin Kuang, Jing Ling, Tuo Zhang, Yadi Wu, Jing Du, Feng Yao, Y. Eugene Chin, Qi Wang, Binhua P. Zhou, Jiong Deng
Publikováno v:
JCI Insight, Vol 8, Iss 1 (2023)
Chronic inflammation is associated with lung tumorigenesis, in which NF-κB–mediated epigenetic regulation plays a critical role. Lung tumor suppressor G protein–coupled receptor, family C, member 5A (GPRC5A), is repressed in most non–small cel
Externí odkaz:
https://doaj.org/article/d70ba8a6a4c4438f996582c1fb6c2c9b
Autor:
Jianli He, Xun Shangguan, Wei Zhou, Ying Cao, Quan Zheng, Jun Tu, Gaolei Hu, Zi Liang, Cen Jiang, Liufu Deng, Shengdian Wang, Wen Yang, Yong Zuo, Jiao Ma, Rong Cai, Yalan Chen, Qiuju Fan, Baijun Dong, Wei Xue, Hongsheng Tan, Yitao Qi, Jianmin Gu, Bing Su, Y. Eugene Chin, Guoqiang Chen, Qi Wang, Tianshi Wang, Jinke Cheng
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and mem
Externí odkaz:
https://doaj.org/article/102b38001d4a4513871efcad72767745
Autor:
Xiang-Rong Li, Xiaju Cheng, Jia Sun, Yan S. Xu, Nannan Chen, Yimei Hao, Chao Huang, Y. Eugene Chin
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Besides their original regulating roles in the brain, spinal cord, retina, and peripheral nervous system for mediating fast excitatory synaptic transmission, glutamate receptors consisting of metabotropic glutamate receptors (GluRs) and iono
Externí odkaz:
https://doaj.org/article/ee548b72f18745488e11afb53abf6e49
Autor:
Mengmeng Xu, Ying Kong, Nannan Chen, Wenlong Peng, Ruidong Zi, Manman Jiang, Jinfeng Zhu, Yuting Wang, Jicheng Yue, Jinrong Lv, Yuanyuan Zeng, Y. Eugene Chin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundUlcerative colitis (UC) is an inflammatory disease of the intestinal mucosa, and its incidence is steadily increasing worldwide. Intestinal immune dysfunction has been identified as a central event in UC pathogenesis. However, the underlyin
Externí odkaz:
https://doaj.org/article/9eb17c6f9ed940e88ee139c2d947a913
Autor:
Lin Hu, Jing Wang, Yunliang Wang, Linpeng Wu, Chao Wu, Bo Mao, E. Maruthi Prasad, Yuhong Wang, Y. Eugene Chin
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background LOX-like 1 (LOXL1) is a lysyl oxidase, and emerging evidence has revealed its effect on malignant cancer progression. However, its role in colorectal cancer (CRC) and the underlying molecular mechanisms have not yet been elucidate
Externí odkaz:
https://doaj.org/article/400aece343fd49d2bb2421e0dd707ccb
Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
Autor:
Lin Hu, Fuxian Chen, Chao Wu, Jun Wang, Si-si Chen, Xiang-rong Li, Jing Wang, Linpeng Wu, Jian-ping Ding, Jian-chuan Wang, Chao Huang, Hui Zheng, Yu Rao, Yu Sun, Zhijie Chang, Wei Deng, Cheng Luo, Y. Eugene Chin
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103177- (2021)
Summary: The mammalian target of rapamycin (mTOR) is a serine-threonine kinase involved in cellular innate immunity, metabolism, and senescence. FK506-binding protein 12 (FKBP12) inhibits mTOR kinase activity via direct association. The FKBP12-mTOR a
Externí odkaz:
https://doaj.org/article/b2965a81e40b4d1b8790ed81223de156
Autor:
Yuhang Jiang, Cuifeng Li, Qian Wu, Peng An, Laiquan Huang, Jia Wang, Chen Chen, Xi Chen, Fan Zhang, Li Ma, Sanhong Liu, Hanqing He, Shuyun Xie, Yangbai Sun, Hanshao Liu, Yu Zhan, Yu Tao, Zhi Liu, Xiaohua Sun, Yiming Hu, Qi Wang, Deji Ye, Jie Zhang, Shanhua Zou, Ying Wang, Gang Wei, Yongzhong Liu, Yufang Shi, Y. Eugene Chin, Yongqiang Hao, Fudi Wang, Xiaoren Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter. Using a measles vaccination murine model, they show that iron-deficient individuals have a significantly reduce
Externí odkaz:
https://doaj.org/article/2f369b436b384d20839dab99bd0c13c5
Autor:
Fei Chen, Qilai Long, Da Fu, Dexiang Zhu, Yan Ji, Liu Han, Boyi Zhang, Qixia Xu, Bingjie Liu, Yan Li, Shanshan Wu, Chen Yang, Min Qian, Jianmin Xu, Suling Liu, Liu Cao, Y. Eugene Chin, Eric W.-F. Lam, Jean-Philippe Coppé, Yu Sun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Tumour microenvironment actively contributes to drug resistance in clinical oncology. Here, the authors show that genotoxic stress induces senescence in human stromal cells, which in turn secrete serine protease inhibitor Kazal type 1 (SPINK1) and pr
Externí odkaz:
https://doaj.org/article/814d6dc53fea4b498e4d863a03b8fd96
Autor:
Boyi Zhang, Da Fu, Qixia Xu, Xianling Cong, Chunyan Wu, Xiaoming Zhong, Yushui Ma, Zhongwei Lv, Fei Chen, Liu Han, Min Qian, Y. Eugene Chin, Eric W. -F. Lam, Paul Chiao, Yu Sun
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1
Externí odkaz:
https://doaj.org/article/38fe8f7806684fd2a11d5418e60e0cf1