Zobrazeno 1 - 10
of 6 263
pro vyhledávání: '"Y. CHIANG"'
Autor:
Pei-Hsun Sung, Ya Yue, Yi-Ling Chen, John Y. Chiang, Ben-Chung Cheng, Chih-Chao Yang, Han-Tan Chai, Hon-Kan Yip
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117567- (2024)
Background: This study tested whether combined dapagliflozin (DAPA) and roxadustat (ROX) therapy was superior to a singular therapy in protecting heart and kidney functions in rats with cardiorenal syndrome (CRS). Methods and results: An in vitro stu
Externí odkaz:
https://doaj.org/article/2560481bcecf42fcab507489c7caaca8
Autor:
Rajbharan Yadav, Suzanne Schubbert, Patrick G. Holder, Eugene Y. Chiang, Nargess Kiabi, Liz Bogaert, Irene Leung, Rumana Rashid, Kendra N. Avery, Christine Bonzon, John R. Desjarlais, Shomyseh Sanjabi, Amy Sharma, Michelle Lepherd, Amy Shelton, Pam Chan, Yanqiu Liu, Louis Joslyn, Iraj Hosseini, Eric G. Stefanich, Amrita V. Kamath, Matthew J. Bernett, Vittal Shivva
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionInterleukin 15 (IL-15) is a potential anticancer agent and numerous engineered IL-15 agonists are currently under clinical investigation. Selective targeting of IL-15 to specific lymphocytes may enhance therapeutic effects while helping t
Externí odkaz:
https://doaj.org/article/31030b79b4034614806d2f9e04a075ba
Autor:
Ason C. Y. Chiang, Jan Ježek, Peiqiang Mu, Ying Di, Anna Klucnika, Martin Jabůrek, Petr Ježek, Hansong Ma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Genetic screens have been used extensively to probe interactions between nuclear genes and their impact on phenotypes. Probing interactions between mitochondrial genes and their phenotypic outcome, however, has not been possible due to a lac
Externí odkaz:
https://doaj.org/article/535c6d0b32ad4ccfa77fbdd9ef88c699
Autor:
Jiunn-Jye Sheu, Jui-Ning Yeh, Pei-Hsun Sung, John Y. Chiang, Yi-Ling Chen, Yi-Ting Wang, Hon-Kan Yip, Jun Guo
Publikováno v:
Cell Transplantation, Vol 33 (2024)
This study tested the hypothesis that ITRI Biofilm prevents adhesion of the chest cavity. Combined extracorporeal shock wave (ECSW) + bone marrow-derived autologous endothelial progenitor cell (EPC) therapy was superior to monotherapy for improving h
Externí odkaz:
https://doaj.org/article/0001a9dd08514016a0bbd890ad2074d1
Autor:
Chih‐Chao Yang, Yi-Ling Chen, Pei-Hsun Sung, John Y. Chiang, Chih-Hung Chen, Yi-Chen Li, Hon-Kan Yip
Publikováno v:
Biomedical Journal, Vol 47, Iss 2, Pp 100613- (2024)
Background: Diabetic kidney disease (DKD) is one of the most significant public health burdens worldwide. This study explored the renal protections of combined adipose-derived mesenchymal stem cells (ADMSCs) and empagliflozin (EMPA) in DKD rats. Meth
Externí odkaz:
https://doaj.org/article/95c57fbb64524804bfd2dc477133c8af
Autor:
Jill C. Chappell, Alan Y. Chiang, Jane Royalty, Hugh Coleman, Palaniappan Kulanthaivel, P. Kellie Turner
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 9, Pp 1617-1627 (2023)
Abstract Abemaciclib is an orally administered, potent, and selective small molecule inhibitor of cyclin‐dependent kinases 4 and 6, approved for advanced or metastatic breast cancer. This study aimed to use an exposure–response approach to invest
Externí odkaz:
https://doaj.org/article/7d79069f08db4c7885afaca6440b2721
Autor:
Rajan K C, Nehal R Patel, Anoushka Shenoy, Joshua P Scallan, Mark Y Chiang, Maria J Galazo, Stryder M Meadows
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302926 (2024)
Zinc Finger MIZ-Type Containing 1 (Zmiz1), also known as ZIMP10 or RAI17, is a transcription cofactor and member of the Protein Inhibitor of Activated STAT (PIAS) family of proteins. Zmiz1 is critical for a variety of biological processes including v
Externí odkaz:
https://doaj.org/article/b35635093e6e478ba4548fad9d251d1e
Autor:
Yen-Ta Chen, Chih-Chao Yang, John Y. Chiang, Pei-Hsun Sung, Pei-Lin Shao, Chi-Ruei Huang, Mel S. Lee, Hon-Kan Yip
Publikováno v:
Cell Transplantation, Vol 32 (2023)
Background: We tested the hypothesis that overexpression of cellular-prion-protein in adipose-derived mesenchymal stem cells (PrPC OE -ADMSCs) effectively protected the kidney against ischemia-reperfusion (IR) injury in rat. Methods: Part I of cell c
Externí odkaz:
https://doaj.org/article/038ca0cee1ef4435bf79c324f4c455d8
Autor:
Yan Qu, Ira Mellman, Ellen Duong, Thomas D Wu, Eugene Y Chiang, Katherine Nutsch, Karl L Banta, Charles W Tran, Stephanie Mittman, Barzin Y Nabet, Namrata S Patil
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/5a68ddaf764c4d40afd06e0a458c6d04
Autor:
Herschel S Dhekne, Francesca Tonelli, Wondwossen M Yeshaw, Claire Y Chiang, Charles Limouse, Ebsy Jaimon, Elena Purlyte, Dario R Alessi, Suzanne R Pfeffer
Publikováno v:
eLife, Vol 12 (2023)
Activating mutations in the leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases, particularly Rab10 and Rab8A, and we showed previously that these phosphoRabs play an important role in LRRK2
Externí odkaz:
https://doaj.org/article/3565c7f6dcf745449d8d8cc68bd1cf97