Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Y. C. Bechtel"'
Autor:
S Hrusovsky, P. R. Bechtel, Gilles Paintaud, Hervé Le-Louët, Y. C. Bechtel, M P Brientini, G. Mantion, Jean-Philippe Miguet
Publikováno v:
Europe PubMed Central
Aim To study drug metabolism in patients before and after liver transplantation using caffeine as a probe drug. Forty-five patients undergoing liver transplantation for various liver diseases and who had well documented dossiers were selected for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c47494e07cc49ee302fa024ec7668c
https://doi.org/10.5414/cpp39053
https://doi.org/10.5414/cpp39053
Autor:
Y. C. Bechtel, P Agache, Gilles Paintaud, P. Humbert, A Bendriss, J. Magnette, Bendriss Ek, P. R. Bechtel
Publikováno v:
British Journal of Clinical Pharmacology. 41:421-424
Eight patients with psoriasis were given 200 mg caffeine orally with or without 1.2 mg kg-1 of 5-methoxypsoralen. Blood and urine samples were collected over a 2-day period. During 5-methoxypsoralen coadministration, the apparent volume of distributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4d50de667c9576a33c4a09450b5121
https://doi.org/10.1046/j.1365-2125.1996.33311.x
https://doi.org/10.1046/j.1365-2125.1996.33311.x
Publikováno v:
Therapie. 56(4)
The great variability of slow acetylator (SA) and/or rapid acetylator (RA) frequency is mainly due to ethnic-racial origin. Using the urinary elimination ratio of three metabolites of caffeine--acetylamino formylamino methyluracil (AFMU) to AFMU + 1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63f86c924252fc7e49d30cd1794dc283
https://pubmed.ncbi.nlm.nih.gov/11677864
https://pubmed.ncbi.nlm.nih.gov/11677864
Autor:
Y. C. Bechtel, P. R. Bechtel, Gilles Paintaud, Jean-Philippe Miguet, Emmanuel Haffen, Hervé Le-Louët, M P Brientini
Publikováno v:
Europe PubMed Central
OBJECTIVES To evaluate the polygenic regulated caffeine metabolism in a group of 226 patients with liver alcoholic cirrhosis classified according to the Child score. METHODS Over a 14-year period an hepatic function test, using caffeine as probe drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2ebd7fede96cfe37e5bdfa3b785356
https://pubmed.ncbi.nlm.nih.gov/11073287
https://pubmed.ncbi.nlm.nih.gov/11073287
Publikováno v:
Therapie. 55(3)
Using the validated probe drug debrisoquine and the 8 h urinary metabolic ratio debrisoquine/4 hydroxy-debrisoquine, we have determined the phenotype of the debrisoquine CYP2D6 dependent polymorphic metabolism in 464 Arabs, 227 Berbers and 215 Numide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b3d24d2234ed6040c21ff107e92c83e
https://pubmed.ncbi.nlm.nih.gov/10967712
https://pubmed.ncbi.nlm.nih.gov/10967712
Publikováno v:
Therapie. 55(3)
Acetylation status was compared, using caffeine as a probe drug, in the three main racial/ethnic groups living in Tunisia: Arabs, Berbers and Numides. The frequency of slow acetylators appears identical in these three groups and is different from tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d84e7d19ed937fb0c7b610fcfbc23df
https://pubmed.ncbi.nlm.nih.gov/10967713
https://pubmed.ncbi.nlm.nih.gov/10967713
Autor:
Emmanuel Haffen, P. R. Bechtel, Y. C. Bechtel, Carole Masuyer, Gilles Paintaud, Michel Bérard
Publikováno v:
Therapeutic drug monitoring. 22(3)
Codeine and its main metabolites appear to have advantages for assessing drug metabolic phenotypes. The authors have further developed a high-performance liquid chromatography (HPLC) method for the quantification of codeine and six of its metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92201e00924ed74bf2847afeca79a89
https://pubmed.ncbi.nlm.nih.gov/10850391
https://pubmed.ncbi.nlm.nih.gov/10850391
Autor:
Jean-Philippe Miguet, Bendriss Ek, Gilles Paintaud, P. R. Bechtel, G. Mantion, Bennani A, Y. C. Bechtel, M P Brientini
Publikováno v:
Europe PubMed Central
The consequences of liver transplantation on NAT2 activity were studied in 58 patients of Caucasian origin and compared with a group control of 119 unrelated healthy individuals of the same ethnic origin. Acetylation phenotypes were determined using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d65046cddbd1eba6ff1f2408ca3a29
https://pubmed.ncbi.nlm.nih.gov/9682266
https://pubmed.ncbi.nlm.nih.gov/9682266
Publikováno v:
European journal of clinical pharmacology. 54(1)
After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6450d38e1024864077c765c0cadedeb4
https://pubmed.ncbi.nlm.nih.gov/9591930
https://pubmed.ncbi.nlm.nih.gov/9591930
Publikováno v:
European journal of clinical pharmacology. 47(5)
CYP1A2 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons. This induction could be mediated via the Ah locus, which encodes a cytosolic receptor responsible for the regulation of the CYP1A1 gene. Enzyme activity in vivo can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba7f196b086cea12daa20eeff85c4a1
https://pubmed.ncbi.nlm.nih.gov/7720764
https://pubmed.ncbi.nlm.nih.gov/7720764