Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Y. Ann Chen"'
Autor:
Michael F. Emmons, Richard L. Bennett, Alberto Riva, Kanchan Gupta, Larissa Anastasio Da Costa Carvalho, Chao Zhang, Robert Macaulay, Daphne Dupéré-Richér, Bin Fang, Edward Seto, John M. Koomen, Jiannong Li, Y. Ann Chen, Peter A. Forsyth, Jonathan D. Licht, Keiran S. M. Smalley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Melanomas can adopt multiple transcriptional states. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity. Here, we identify stress-induced HDAC8 activity as driving melan
Externí odkaz:
https://doaj.org/article/eaa6d6439c614e83a09975f61db4c4e0
Autor:
Alyssa N. Obermayer, Darwin Chang, Gabrielle Nobles, Mingxiang Teng, Aik-Choon Tan, Xuefeng Wang, Y. Ann Chen, Steven Eschrich, Paulo C. Rodriguez, G. Daniel Grass, Soheil Meshinchi, Ahmad Tarhini, Dung-tsa Chen, Timothy I. Shaw
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Pathway-level survival analysis offers the opportunity to examine molecular pathways and immune signatures that influence patient outcomes. However, available survival analysis algorithms are limited in pathway-level function and lack a stre
Externí odkaz:
https://doaj.org/article/a8a184167ea846a0a4bc7b36d14d1a13
Autor:
Kathy L. McGraw, Chia-Ho Cheng, Y. Ann Chen, Hsin-An Hou, Björn Nilsson, Giulio Genovese, Thomas Cluzeau, Andrea Pellagatti, Bartlomiej P. Przychodzen, Mar Mallo, Leonor Arenillas, Azim Mohamedali, Lionel Adès, David A. Sallman, Eric Padron, Lubomir Sokol, Chimene Moreilhon, Sophie Raynaud, Hwei-Fang Tien, Jacqueline Boultwood, Benjamin L. Ebert, Francesc Sole, Pierre Fenaux, Ghulam J. Mufti, Jaroslaw P. Maciejewski, Peter A. Kanetsky, Alan F. List
Publikováno v:
Blood Advances, Vol 3, Iss 22, Pp 3579-3589 (2019)
Abstract: Myelodysplastic syndromes (MDS) are hematopoietic stem cell malignancies. Known predisposing factors to adult MDS include rare germline mutations, cytotoxic therapy, age-related clonal hematopoiesis, and autoimmune or chronic inflammatory d
Externí odkaz:
https://doaj.org/article/cf1ad2d32c354d1dad1743567cc1316e
Autor:
Inna Smalley, Eunjung Kim, Jiannong Li, Paige Spence, Clayton J. Wyatt, Zeynep Eroglu, Vernon K. Sondak, Jane L. Messina, Nalan Akgul Babacan, Silvya Stuchi Maria-Engler, Lesley De Armas, Sion L. Williams, Robert A. Gatenby, Y. Ann Chen, Alexander R.A. Anderson, Keiran S.M. Smalley
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 178-190 (2019)
Background: Melanoma is a heterogeneous tumour, but the impact of this heterogeneity upon therapeutic response is not well understood. Methods: Single cell mRNA analysis was used to define the transcriptional heterogeneity of melanoma and its dynamic
Externí odkaz:
https://doaj.org/article/7d086aa6efdb4ee5a9b2cf678b89c9e9
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background The rapid development of single-cell RNA sequencing (scRNA-seq) provides unprecedented opportunities to study the tumor ecosystem that involves a heterogeneous mixture of cell types. However, the majority of previous and current s
Externí odkaz:
https://doaj.org/article/aeb9ef1fd1eb4d15ad3409bf1f0b94e7
Autor:
Saurabh K. Garg, Matthew J. Ott, A. G. M. Mostofa, Zhihua Chen, Y. Ann Chen, Jodi Kroeger, Biwei Cao, Adam W. Mailloux, Alisha Agrawal, Braydon J. Schaible, Amod Sarnaik, Jeffrey S. Weber, Anders E. Berglund, James J. Mulé, Joseph Markowitz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Phenotyping of immune cell subsets in clinical trials is limited to well-defined phenotypes, due to technological limitations of reporting flow cytometry multi-dimensional phenotyping data. We developed a multi-dimensional phenotyping analysis tool a
Externí odkaz:
https://doaj.org/article/27868eabfece4beba9ed09c42344dbf3
Publikováno v:
International Journal of Genomics, Vol 2017 (2017)
Externí odkaz:
https://doaj.org/article/5569a23d72594853975494b7c3a69723
Autor:
Joseph Markowitz, Ragini Kudchadkar, Jeffrey S. Weber, Zeynep Eroglu, Andrew S. Brohl, Nikhil I. Khushalani, Ram Thapa, Y. Ann Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background Ipilimumab and peginterferon alfa-2b are established systemic treatment options for melanoma that have distinct mechanisms of action. Given the need for improved therapies for advanced melanoma, we conducted an open-label, single instituti
Externí odkaz:
https://doaj.org/article/f3fd764baf5648f88945056d229d82ff
Publikováno v:
Analytical Chemistry. 95:7127-7133
Autor:
Manali S. Phadke, Jiannong Li, Zhihua Chen, Paulo C. Rodriguez, J.K. Mandula, Lilit Karapetyan, Peter A. Forsyth, Y. Ann Chen, Keiran S.M. Smalley
BackgroundAlthough the anti-PD-1+LAG-3 and the anti-PD-1+CTLA-4 combinations are effective in advanced melanoma it remains unclear whether their mechanisms of action and resistance overlap.MethodsWe used single cell (sc) RNA-seq, flow cytometry and I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556b70b83cee78ac090c62f51cbe0443
https://doi.org/10.1101/2023.04.14.536907
https://doi.org/10.1101/2023.04.14.536907