Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Y-M. Wong"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Despite significant advances in the development of therapeutics for hearing loss, drug delivery to the middle and inner ear remains a challenge. As conventional oral or intravascular administration are ineffective due to poor bioavailability and impe
Externí odkaz:
https://doaj.org/article/91833ae8757548e38797c3240e29e1aa
Autor:
Joey Lye, Derek S. Delaney, Fiona K. Leith, Varda S. Sardesai, Samuel McLenachan, Fred K. Chen, Marcus D. Atlas, Elaine Y. M. Wong
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3347 (2023)
Up to 1.5 billion people worldwide suffer from various forms of hearing loss, with an additional 1.1 billion people at risk from various insults such as increased consumption of recreational noise-emitting devices and ageing. The most common type of
Externí odkaz:
https://doaj.org/article/67c4483bde4d4591ad7fb3de626eb34b
Autor:
Zengping Liu, Tanja Ilmarinen, Gavin S. W. Tan, Heidi Hongisto, Edmund Y. M. Wong, Andrew S. H. Tsai, Sami Al-Nawaiseh, Graham E. Holder, Xinyi Su, Veluchamy Amutha Barathi, Heli Skottman, Boris V. Stanzel
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell replacement therapy but often lack standardized cell production and live-cell shipment logistics as well as rigorous analyses of surgical proced
Externí odkaz:
https://doaj.org/article/79af98e8d625467a8668cca14fc1c485
Autor:
Susanna K. P. Lau, Rachel Y. Y. Fan, Longchao Zhu, Kenneth S. M. Li, Antonio C. P. Wong, Hayes K. H. Luk, Emily Y. M. Wong, Carol S. F. Lam, George C. S. Lo, Joshua Fung, Zirong He, Felix C. H. Fok, Rex K. H. Au-Yeung, Libiao Zhang, Kin-Hang Kok, Kwok-Yung Yuen, Patrick C. Y. Woo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Several human coronaviruses (CoV) have been proposed to emerge from bats but evidence of direct bat-to-human transmission is slim. In this work, the authors isolate a MERS-related CoV strain directly from bats and show that it infects target cells in
Externí odkaz:
https://doaj.org/article/0e0c505e69d14f01826f70c19f4cde59
Autor:
Susanna K. P. Lau, Rachel Y. Y. Fan, Hayes K. H. Luk, Longchao Zhu, Joshua Fung, Kenneth S. M. Li, Emily Y. M. Wong, Syed Shakeel Ahmed, Jasper F. W. Chan, Raven K. H. Kok, Kwok-Hung Chan, Ulrich Wernery, Kwok-Yung Yuen, Patrick C. Y. Woo
Publikováno v:
Emerging Microbes and Infections, Vol 7, Iss 1, Pp 1-11 (2018)
Abstract Previous findings of Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses in bats, and the ability of Tylonycteris-BatCoV HKU4 spike protein to utilize MERS-CoV receptor, human dipeptidyl peptidase 4 hDPP4, suggest a bat a
Externí odkaz:
https://doaj.org/article/10fb4f8dac484d45baa1ff12e13eaeeb
Autor:
Susanna K. P. Lau, David C. Lung, Emily Y. M. Wong, Kam Leng Aw-Yong, Antonio C. P. Wong, Hayes K. H. Luk, Kenneth S. M. Li, Joshua Fung, Tony T. Y. Chan, James Y. M. Tang, Longchao Zhu, Cyril C. Y. Yip, Sally C. Y. Wong, Rodney A. Lee, Owen T. Y. Tsang, Kwok-Yung Yuen, Patrick C. Y. Woo
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Since its first appearance in the 1960s, the genetic diversity and evolution of human coronavirus 229E (HCoV-229E) have been relatively understudied. In this study, we report a fatal case of COVID-19 coinfected with HCoV-229E in Hong Kong.
Externí odkaz:
https://doaj.org/article/f15381cee8744cbf9d0566546fb34d76
Autor:
Meg Whatley, Abbie Francis, Zi Ying Ng, Xin Ee Khoh, Marcus D. Atlas, Rodney J. Dilley, Elaine Y. M. Wong
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Usher syndrome (USH) is an autosomal recessive (AR) disorder that permanently and severely affects the senses of hearing, vision, and balance. Three clinically distinct types of USH have been identified, decreasing in severity from Type 1 to 3, with
Externí odkaz:
https://doaj.org/article/b250574c6edf428b8e53dc3d70097629
Autor:
T, André, S, Lonardi, K Y M, Wong, H-J, Lenz, F, Gelsomino, M, Aglietta, M A, Morse, E, Van Cutsem, R, McDermott, A, Hill, M B, Sawyer, A, Hendlisz, B, Neyns, S, Abdullaev, A, Memaj, M, Lei, M, Dixon, S, Kopetz, M J, Overman
Publikováno v:
Annals of Oncology. 33:1052-1060
BACKGROUND: In the phase II multicohort CheckMate 142 study, nivolumab plus low-dose (1 mg/kg) ipilimumab provided robust and durable clinical benefit with a manageable safety profile in previously treated patients with microsatellite instability-hig
Autor:
Jade L. L. Teng, Ulrich Wernery, Po Chun Wong, Elaine Chan, Hwei Huih Lee, Sunitha Joseph, Ru Bai, Ying Tang, Emily Y. M. Wong, Susanna K. P. Lau, Patrick C. Y. Woo
Publikováno v:
Viruses, Vol 13, Iss 3, p 430 (2021)
Picobirnaviruses (PBVs) are small non-enveloped bisegmented double-stranded RNA viruses found in humans, mammals, and birds. Increasing molecular epidemiology studies suggest a high sequence diversity of PBVs in numerous hosts and the environment. In
Externí odkaz:
https://doaj.org/article/e63a12cf90ca44d49db819e8a74e8c51
Autor:
Susanna K P Lau, Renate Wernery, Emily Y M Wong, Sunitha Joseph, Alan K L Tsang, Nissy Annie Georgy Patteril, Shyna K Elizabeth, Kwok-Hung Chan, Rubeena Muhammed, Jöerg Kinne, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
Publikováno v:
Emerging Microbes and Infections, Vol 5, Iss 1, Pp 1-9 (2016)
Little is known regarding the molecular epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) circulating in dromedaries outside Saudi Arabia. To address this knowledge gap, we sequenced 10 complete genomes of MERS-CoVs isolated fro
Externí odkaz:
https://doaj.org/article/366744dc7fbd445fbd57c9eac3a4f5f4