Essential roles for deubiquitination in Leishmania life cycle progression.

Autor: Andreas Damianou, Rebecca J Burge, Carolina M C Catta-Preta, Vincent Geoghegan, Y Romina Nievas, Katherine Newling, Elaine Brown, Richard Burchmore, Boris Rodenko, Jeremy C Mottram

Publikováno v: PLoS Pathogens, Vol 16, Iss 6, p e1008455 (2020)

The parasitic protozoan Leishmania requires proteasomal, autophagic and lysosomal proteolytic pathways to enact the extensive cellular remodelling that occurs during its life cycle. The proteasome is essential for parasite proliferation, yet little i

Externí odkaz: https://doaj.org/article/8acf2f02f6934275a61fe7224766006e

Distinguishing functions of trypanosomatid protein kinases

Autor: Mathieu Cayla, Y. Romina Nievas, Keith R. Matthews, Jeremy C. Mottram

Publikováno v: Cayla, M, Nievas, Y R, Matthews, K R & Mottram, J C 2022, ' Distinguishing functions of trypanosomatid protein kinases ', Trends in Parasitology, vol. 38, no. 11, pp. 950-961 . https://doi.org/10.1016/j.pt.2022.08.009

Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts. Understanding how these organisms respond, adapt, and persist in their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a3593efdac6330ca774b034706f348
https://pubmed.ncbi.nlm.nih.gov/36075845