Zobrazeno 1 - 10
of 381
pro vyhledávání: '"Y Nemerson"'
Autor:
Y. Nemerson, J.J. Hathcock
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:P-S
Publikováno v:
Blood. 96:170-175
We describe thrombogenic tissue factor (TF) on leukocyte-derived microparticles and their incorporation into spontaneous human thrombi. Polymorphonuclear leukocytes and monocytes transfer TF+particles to platelets, thereby making them capable of trig
Publikováno v:
Biophysical Journal. 69:356-361
Many in vivo enzymatic processes, such as those of the tissue factor pathway of blood coagulation, occur in environments with facilitated substrate delivery or enzymes bound to cellular or lipid surfaces, which are quite different from the ideal flui
Autor:
Y. Nemerson, H. A. M. Andree
Publikováno v:
Blood Coagulation & Fibrinolysis. 6:189-197
Tissue factor (TF), a transmembrane protein, is the main initiator of blood clotting in vivo which functions by complexing the enzyme, factor VIIa, which then activates its natural substrates, factors IX and X. TF functions by increasing the affinity
Publikováno v:
Blood. 81:2050-2058
Endothelial cell-mediated coagulation and leukocyte adhesion are processes that might be connected by the generation of thrombin. To examine the interaction of procoagulant and proadhesive activity, cultures of endothelial cells were stimulated with
Publikováno v:
Blood. 76:2266-2271
A microperfusion system containing a glass capillary, the inner surface of which is coated with a phospholipid bilayer containing tissue factor, was used to explore the requirement for factors VIIa and Xa in the complex formed with the lipoprotein-as
Publikováno v:
Thrombosis and haemostasis. 86(3)
Autor:
P L, Giesen, B S, Fyfe, J T, Fallon, M, Roque, M, Mendlowitz, M, Rossikhina, A, Guha, J J, Badimon, Y, Nemerson, M B, Taubman
Publikováno v:
Thrombosis and haemostasis. 83(4)
Tissue factor (TF), the initiator of coagulation, has been implicated as a critical mediator of arterial thrombosis. Previous studies have demonstrated that TF is rapidly induced in the normal rodent arterial wall by balloon injury, but is not associ
Publikováno v:
Thrombosis and haemostasis. 82(2)
The last few years have provided increasing evidence to support a major role for TF in the initiation and propagation of thrombosis after acute arterial injury. Although thrombotic occlusion occurs in a small minority of patients undergoing acute cor
Autor:
Y, Nemerson, P L, Giesen
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 9
It is likely that tissue factor (TF) evolved as a haemostatic protein and, as such, it is highly concentrated in vascular tissue. Most cell surface TF is latent and simple exposure of the cell surface to circulating procoagulant proteins is not suffi