Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Y M, Lawal"'
Autor:
Y. M. Lawal, Susan K. Paulson, M. A. Berge, A. P. Breau, N. W. K. Liu, S. M. Jessen, Y. F. Wang, Josh J. Yuan, C. S. Markos, Jeremy D. Hribar, D. Yang, C. M. Dudkowski, J. W. A. Findlay, M. Chang, Ji Y. Zhang
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 30(7)
1. The metabolism and excretion of celecoxib, a specific cyclooxygenase 2 (COX-2) inhibitor, was investigated in mouse, rabbit, the EM (extensive) and PM (poor metabolizer) dog, and rhesus and cynomolgus monkey. 2. Some sex and species differences we
Autor:
S K, Paulson, J Y, Zhang, A P, Breau, J D, Hribar, N W, Liu, S M, Jessen, Y M, Lawal, J N, Cogburn, C J, Gresk, C S, Markos, T J, Maziasz, G L, Schoenhard, E G, Burton
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(5)
The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, a cyclooxygenase-2 inhibitor, were investigated in rats. Celecoxib was metabolized exten