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Akademický článek

Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation

Autor: Fan Li, Jazlyn Gallego, Natasha N. Tirko, Jenna Greaser, Derek Bashe, Rudra Patel, Eric Shaker, Grace E. Van Valkenburg, Alanoud S. Alsubhi, Steven Wellman, Vanshika Singh, Camila Garcia Padilla, Kyle W. Gheres, John I. Broussard, Roger Bagwell, Maureen Mulvihill, Takashi D. Y. Kozai

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Microglia are important players in surveillance and repair of the brain. Implanting an electrode into the cortex activates microglia, produces an inflammatory cascade, triggers the foreign body response, and opens the blood-brain barrier. Th

Externí odkaz: https://doaj.org/article/91f91a8693bf47b1a4a20e5cbc4a9141

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Akademický článek

Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

Autor: Nicholas F. Fitz, Kyong Nyon Nam, Cody M. Wolfe, Florent Letronne, Brittany E. Playso, Bistra E. Iordanova, Takashi D. Y. Kozai, Richard J. Biedrzycki, Valerian E. Kagan, Yulia Y. Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamova

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Microglia can clear amyloid plaques in Alzheimer’s disease. Here, the authors show that specific isoforms of the phospholipid forming APOE lipoproteins activate microglia in pre-clinical mouse models of Alzheimer’s disease.

Externí odkaz: https://doaj.org/article/16908adbabbe48e7b4e51149f560d6dc

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Akademický článek

Revealing Spatial and Temporal Patterns of Cell Death, Glial Proliferation, and Blood-Brain Barrier Dysfunction Around Implanted Intracortical Neural Interfaces

Autor: Steven M. Wellman, Lehong Li, Yalikun Yaxiaer, Ingrid McNamara, Takashi D. Y. Kozai

Publikováno v: Frontiers in Neuroscience, Vol 13 (2019)

Improving the long-term performance of neural electrode interfaces requires overcoming severe biological reactions such as neuronal cell death, glial cell activation, and vascular damage in the presence of implanted intracortical devices. Past studie

Externí odkaz: https://doaj.org/article/5a67e30375fe454faba01adbb286b46d

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Akademický článek

In Vivo Electrochemical Analysis of a PEDOT/MWCNT Neural Electrode Coating

Autor: Nicolas A. Alba, Zhanhong J. Du, Kasey A. Catt, Takashi D. Y. Kozai, X. Tracy Cui

Publikováno v: Biosensors, Vol 5, Iss 4, Pp 618-646 (2015)

Neural electrodes hold tremendous potential for improving understanding of brain function and restoring lost neurological functions. Multi-walled carbon nanotube (MWCNT) and dexamethasone (Dex)-doped poly(3,4-ethylenedioxythiophene) (PEDOT) coatings

Externí odkaz: https://doaj.org/article/02000522426641a4bcdc77a63b679fc7

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Akademický článek

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In vivomicrostimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice

Autor: James R. Eles, Kevin C Steiger, Kip A. Ludwig, Takashi D. Y. Kozai

Publikováno v: J Neurosci Res

Electrical stimulation has been critical in the development of an understanding of brain function and disease. Despite its widespread use and obvious clinical potential, the mechanisms governing stimulation in the cortex remain largely unexplored in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763d3f083629f8a09eb81172224aa215
https://doi.org/10.1002/jnr.24676

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Akademický článek

The History and Horizons of Microscale Neural Interfaces

Autor: Takashi D. Y. Kozai

Publikováno v: Micromachines, Vol 9, Iss 9, p 445 (2018)

Microscale neural technologies interface with the nervous system to record and stimulate brain tissue with high spatial and temporal resolution. These devices are being developed to understand the mechanisms that govern brain function, plasticity and

Externí odkaz: https://doaj.org/article/5b7cc2decf18423598f33dfb41030f18

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Recent advances in neural interfaces-Materials chemistry to clinical translation

Autor: Takashi D. Y. Kozai, Ellis Meng, Melanie Ecker, George G. Malliaras, Christopher J. Bettinger, Walter Voit

Publikováno v: MRS Bull
MRS Bulletin

Implantable neural interfaces are important tools to accelerate neuroscience research and translate clinical neurotechnologies. The promise of a bidirectional communication link between the nervous system of humans and computers is compelling, yet im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8a76064d5288637c779ff0fbffebd2
https://pubmed.ncbi.nlm.nih.gov/34690420

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