Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Y K, Pithavala"'
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 49:679-687
Objective To assess axitinib plasma pharmacokinetics and safety of single oral doses of axitinib under fed conditions in healthy Chinese volunteers. Materials and methods This Phase I, open-label study evaluated single dosing of axitinib in 14 health
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575d7925d8b1cb3d3cc05ab1c2424e2e
https://doi.org/10.5414/cp201570
https://doi.org/10.5414/cp201570
Autor:
H L, McLeod, J, Cassidy, R H, Powrie, D G, Priest, M A, Zorbas, T W, Synold, S, Shibata, D, Spicer, D, Bissett, Y K, Pithavala, M A, Collier, L J, Paradiso, J D, Roberts
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)
Glycinamide ribonucleotide formyltransferase (GARFT) is a component of the de novo purine synthesis pathway. AG2034 is a specific inhibitor of GARFT that was designed based on the GARFT crystal structure. In conjunction with Phase I studies at four c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb95df6ce971e27d00a6481a774811b8
https://pubmed.ncbi.nlm.nih.gov/10914709
https://pubmed.ncbi.nlm.nih.gov/10914709
Publikováno v:
Pharmaceutical research. 15(12)
The purpose of this study was to evaluate the extent of ranitidine absorption from an externally activated drug-delivery system in two distinct regions of the intestine (jejunum and ileum) in healthy human volunteers. This investigation also was desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7a587b8f91b1cfe88eacaf81b8004e8
https://pubmed.ncbi.nlm.nih.gov/9892471
https://pubmed.ncbi.nlm.nih.gov/9892471
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(11)
The deconvolution principle was used to evaluate the extent of absorption and first-pass elimination of selected drugs. In the first example, deconvolution of the portal blood profiles of etretinate (ET, a synthetic retinoid) indicated that there was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc4e153958af6f861eac6919a3fb5714
https://pubmed.ncbi.nlm.nih.gov/9351902
https://pubmed.ncbi.nlm.nih.gov/9351902