Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Y John, Wang"'
Autor:
Junyan A Ji, Y John Wang, Kai Zheng, Justin K Y Hong, Diya Ren, Wayne Lilyestrom, Thomas M. Scherer
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2d69f2f72850333e44c5e3c419abd
https://pubmed.ncbi.nlm.nih.gov/33921206
https://pubmed.ncbi.nlm.nih.gov/33921206
Publikováno v:
TrAC Trends in Analytical Chemistry. 101:34-42
Reactive impurities in excipients can cause drug product degradation or protein modification even at trace levels, and thus impact drug stability and quality. It is critical to understand the potential impact of these impurities during development in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6842ca01085e3391fd2f3b1c331170a
https://doi.org/10.1016/j.trac.2017.11.003
https://doi.org/10.1016/j.trac.2017.11.003
Autor:
Amy Hilderbrand, Daniel Bregante, Nisana Andersen, Wayman Chan, Michelle Z. Dion, Y. John Wang, Danielle L. Leiske, Cleo M. Salisbury
Publikováno v:
Journal of Pharmaceutical Sciences. 107:550-558
Protein oxidation is a major pathway for degradation of biologic drug products. Past literature reports have suggested that 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH), a free radical generator that produces alkoxyl and alkyl peroxyl radical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40ad9e0a6eacbac1b1f1ec31f3901d4
https://doi.org/10.1016/j.xphs.2017.09.022
https://doi.org/10.1016/j.xphs.2017.09.022
Autor:
Li Yi, Christian Schöneich, Jessica Bane, Y. John Wang, Alavattam Sreedhara, Olivier Mozziconacci
Publikováno v:
Pharmaceutical Research. 34:229-242
Triply oxidized histidine in an IgG1 monoclonal antibody was noticed when exposed to ICH light conditions. In order to understand the role of light source, irradiation wavelengths and primary sequence, specifically those of a nearby tryptophan, we sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf87050d0ab34f1cda49c3115e466e4e
https://doi.org/10.1007/s11095-016-2058-2
https://doi.org/10.1007/s11095-016-2058-2
Autor:
Barthélemy Demeule, Lin Zhang, Christian Schӧneich, Olivier Mozziconacci, Sandeep Yadav, Y. John Wang
Publikováno v:
Pharmaceutical Research. 34:84-100
To investigate the mechanisms of polysorbate (PS) degradation with the added objective of differentiating the hydrolysis and oxidation pathways. Ultra-performance liquid chromatography mass spectrometry (UPLC-MS) was utilized to characterize all-laur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2841feff30e3fa6db6c3dd6d931aef
https://doi.org/10.1007/s11095-016-2041-y
https://doi.org/10.1007/s11095-016-2041-y
Autor:
Sheila Ulufatu, Reed J. Harris, Zhilan Hu, Roxanne Vega, Jia Chen, Mark Iverson, Cecilia Leddy, Eileen T. Duenas, Xanthe M. Lam, Helen Davis, Christopher Yu, Daniela Bumbaca Yadav, Amy Shen, Dongwei Li, Y. John Wang, Pin Y. Wong, Guoying Jiang, Kai Zheng, Annamarie Amurao, Marc Wong
Publikováno v:
Journal of Pharmaceutical Sciences. 105:2066-2072
Due to their potential influence on stability, pharmacokinetics, and product consistency, antibody charge variants have attracted considerable attention in the biotechnology industry. Subtle to significant differences in the level of charge variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5add41eaaccfc78cdbe5ae83a462e3
https://doi.org/10.1016/j.xphs.2016.04.027
https://doi.org/10.1016/j.xphs.2016.04.027
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 70:332-345
Degradation of the surfactant polysorbate (PS) by enzyme impurities has been previously suggested as a mechanism for the formation of visible and subvisible particles that affect product quality. Although chemical degradation pathways of PS, such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6812c7d2b278ac7e28fbdb83269f0660
https://doi.org/10.5731/pdajpst.2015.005942
https://doi.org/10.5731/pdajpst.2015.005942
Publikováno v:
Pharmaceutical Research. 35
Light is known to induce histidine (His) oxidation and His-His crosslinking in proteins. The crosslinking is resulted from the nucleophilic attack of a His to a photooxidized His from another protein. The goal of this work is to understand if covalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afeaf5654a5e4b838625e88a0dbae8bb
https://doi.org/10.1007/s11095-017-2339-4
https://doi.org/10.1007/s11095-017-2339-4
Autor:
Ada Hui, Y. John Wang, Ulla Grauschopf, Katherine Thomas, Sebastian Schneider, Kirk Eppler, Joerg Luemkemann
Publikováno v:
Challenges in Protein Product Development ISBN: 9783319906010
Biological drug products are usually filled into the primary packaging container under aseptic conditions. Modern fill–finish plants often employ containment installations like isolators to ensure the highest level of sterility assurance for the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8af640c6cd4f64e18f45b2a83a9bd3af
https://doi.org/10.1007/978-3-319-90603-4_18
https://doi.org/10.1007/978-3-319-90603-4_18
Publikováno v:
Pharmaceutical research. 35(2)
L-Histidine (L-His) and polysorbate 20 (PS20) are two excipients frequently included in parenteral products to stabilize biotherapeutics. The objective of the current work was to investigate the impact of L-His on PS20 stability in aqueous solutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87386ecd21f7df418cb4c35bfedb4ff1
https://pubmed.ncbi.nlm.nih.gov/29368235
https://pubmed.ncbi.nlm.nih.gov/29368235