Výsledky vyhledávání - "Y Haberman Ziv"

P089 Long ncRNA Landscape in the Rectum of Treatment Naïve Early Onset Ulcerative Colitis Highlights Association with Severity and Early and Late Disease Outcome, with Potential Role in Epithelial Metabolic Functions

Autor: Y Haberman Ziv, T Braun, K Sosnovski, A Amir, K VanDussen, I U Igor Ulitsky, A Griffiths, T Walters, D Mack, B Boyle, S Kugathasan, A Jegga, J Hyams, L Denson

Publikováno v: Journal of Crohn's and Colitis. 16:i187-i189

Background Long non-coding RNAs (lncRNAs) are tissue-specific and regulate cellular functions. We previously reported a dramatic inhibition of epithelial metabolic mitochondrial functions in mucosal biopsies from the UC PROTECT cohort. We aimed to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5095c0a14e22d30e59412b9e7ea866df
https://doi.org/10.1093/ecco-jcc/jjab232.218

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P046 Crohn Disease (CD) untargeted fecal metabolome shows strong correlation with specific salivary associated microbial taxa, and with disease activity

Autor: N Levhar, R Hadar, T Braun, G Efroni, I Abramovich, E Gottlieb, M Granot, S Neuman, L Selinger, O Picard, M Yavzori, A Lahat, R Eliakim, B Weiss, U Kopylov, S Ben-Horin, A Amir, Y Haberman Ziv

Publikováno v: Journal of Crohn's and Colitis. 17:i213-i214

Background The fecal metabolome is comprised from derivatives of the gut microbiome, the host, the environment, and the diet. Thus, it is a central output and effector that is linked with Crohn disease (CD). We aimed to characterize metabolomics prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74d498eb146c2119b91b2f9402a40210
https://doi.org/10.1093/ecco-jcc/jjac190.0176

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P004 Untargeted serum metabolome shows Crohn Disease (CD) associated signature, signals that correlate with disease activity and CRP, and signals that may precede disease flare

Autor: N Levhar, R Hadar, T Braun, G Efroni, I Abramovich, E Gottlieb, M Granot, N Sandra, L Selinger, O Picard, M Yavzori, A Lahat, R Eliakim, B Weiss, U Kopylov, S Ben-Horin, A Amir, Y Haberman Ziv

Publikováno v: Journal of Crohn's and Colitis. 17:i173-i173

Background The serum metabolome contains potential disease biomarkers, some of which are produced endogenously, derived from the diet, or formed by the gut microbiome. We aimed to characterize metabolomics profiles linked with Crohn Disease (CD), wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78398a55b4ccbb1da7602876376db90e
https://doi.org/10.1093/ecco-jcc/jjac190.0134

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P109 Using baseline Peripheral blood mononuclear cell (PBMC) transcriptomics of Crohn Disease patients receiving Ustekinumab treatment as a tool to assess potential response at 1 year

Autor: M Granot, T Braun, G Efroni, E Fudim, M Yavzori, O Haj, S Ben-Horin, U Kopylov, Y Haberman Ziv

Publikováno v: Journal of Crohn's and Colitis. 17:i273-i273

Background Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and interleukin-23, is used to treat Crohn Disease (CD) and clinical remission after one year was observed in about 50% of patients. We aimed to identify predictors fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e8409be69c2f48288c40f1f6801650c
https://doi.org/10.1093/ecco-jcc/jjac190.0239

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OP31 Dietary and Multi-Omic characterization of new onset treatment naive Crohn Disease identifies factors that may contribute to disease pathogenesis

Autor: Y Haberman Ziv, T Braun, A Amir, N Levhar, A Malik, S Neuman, O Picard, M Yavzuri, G Efroni, R Hadar, S Ben-Horin

Publikováno v: Journal of Crohn's and Colitis. 16:i034-i035

Background Crohn Disease (CD) prevalence is rising worldwide. As altered genetics are improbable, this phenomenon likely relates to environmental-dietary changes linked with gut microbiome. We aimed to define host and microbial factors at CD diagnosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79f67f7f093115d31e4cdba01023db72
https://doi.org/10.1093/ecco-jcc/jjab232.030

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P017 Small bowel transcriptomics define similarities and divergent pathways between Crohn, environmental enteric dysfunction (EED), and celiac diseases, implicating role for the microbiome in the pathogenesis

Autor: Y Haberman Ziv, Chris Moskaluk, Malnutrition (Seem) Pakistan, CCF-supported Risk study, Lee A. Denson, N Rahman, Tzipi Braun, P J Dexheimer, Sana Syed, N T Iqbal, Syed A. Ali, Sean R. Moore, R Hadar

Publikováno v: Journal of Crohn's and Colitis. 15:S136-S137

Background Crohn disease (CD), environmental enteric dysfunction (EED) and celiac disease are prevalent enteropathies linked to chronic gut inflammation. However, unlike celiac and Crohn that are prevalent in westernized countries, EED is seen in onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b39c8aaaf01b1296753c32a77ac8e137
https://doi.org/10.1093/ecco-jcc/jjab076.146

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P041 CDKN2B-AS1 (ANRIL) expression is decreased in Inflammatory Bowel Disease epithelia and in Celiac, and its reduction is linked with induced cells proliferation

Autor: Marina BenShoshan, Katya E. Sosnovski, Yair Anikster, Tzipi Braun, Y Haberman Ziv, Amnon Amir

Publikováno v: Journal of Crohn's and Colitis. 15:S152-S152

Background Long non-coding RNAs (lncRNAs) have attenuated expression in several immune-mediated disorders. Using mRNAseq of intestinal biopsies, we identified a widespread dysregulation of 459 lncRNAs in the ileum of treatment-naïve pediatric Crohn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f8b030a359ba5b7e2543aad9463fb77
https://doi.org/10.1093/ecco-jcc/jjab076.170

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DOP89 Pre-treatment mucosal inflammatory and wound healing gene programmes reveal mechanisms associated with future stricturing behaviour during 5-year follow-up in paediatric Crohn’s disease

Autor: Sudhir Ghandikota, Anil G. Jegga, Suresh Venkateswaran, Brianne Shuler, Phillip Minar, Subra Kugathasan, Rebekah Karns, Greg Gibson, Bruce J. Aronow, J. Hyams, Daniel Shapiro, Phillip J. Dexheimer, Lee A. Denson, Samuel Tegge, Tzipi Braun, Y Haberman Ziv

Publikováno v: Journal of Crohn's and Colitis. 14:S127-S127

Background Stricturing complications account for substantial morbidity in Crohn’s disease (CD). We aimed to define ileal gene programmes present at diagnosis in paediatric CD associated with future stricturing behaviour (B2), and to identify potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01618f05a7539c0dafe301a1c8507fbd
https://doi.org/10.1093/ecco-jcc/jjz203.128

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OP06 Comparison between Crohn and coeliac diseases small intestine transcriptomics and microbial data define similarities and divergent pathways linked to pathogenesis

Autor: B Weiss, Ron Unger, Dror S. Shouval, Gilat Efroni, Lee A. Denson, N Loberman-Nachum, S Katya, Y Haberman Ziv, A Di Segni, Amnon Amir, Tzipi Braun, Marina BenShoshan

Publikováno v: Journal of Crohn's and Colitis. 14:S006-S006

Background Crohn disease and coeliac disease are two inflammatory conditions known to cause small intestine inflammation. Using high throughput transcriptomics, microbial, and bioinformatics approaches we aimed to capture differences and similarities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f429c96117852cb5c141f25e1978c5fc
https://doi.org/10.1093/ecco-jcc/jjz203.005

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