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Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA A receptor α4 subunit expression

Autor: D S, Roberts, Y H, Raol, S, Bandyopadhyay, I V, Lund, E C, Budreck, M A, Passini, M J, Passini, J H, Wolfe, A R, Brooks-Kayal, S J, Russek

Publikováno v: Proceedings of the National Academy of Sciences. 102:11894-11899

GABA is the major inhibitory transmitter at CNS synapses. Changes in subunit composition of the pentameric GABA A receptor, including increased levels of α4 subunit in dentate granule cells and associated functional alterations such as increased zin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afeb4bb8c0020d70fa00bed7e7c50508
https://doi.org/10.1073/pnas.0501434102

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Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus

Autor: H L, Grabenstatter, J, Carlsen, Y H, Raol, T, Yang, D, Hund, Y, Cruz Del Angel, A M, White, M I, Gonzalez, F M, Longo, S J, Russek, A R, Brooks-Kayal

Publikováno v: Journal of neuroscience research. 92(10)

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are initially expressed in a precursor form (e.g., proBDNF) and cleaved to form mature BDNF (mBDNF). Following pilocarpine-induced status epilepticus (SE), increases in neurotrophins re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db054fdad3812f59974b6a58ef94aadb
https://pubmed.ncbi.nlm.nih.gov/24801281

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