Výsledky vyhledávání - "Y George, Zheng"

Akademický článek

A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases

Autor: Subodh Kumar Samrat, Qamar Bashir, Ran Zhang, Yiding Huang, Yuchen Liu, Xiangmeng Wu, Tyler Brown, Wei Wang, Y. George Zheng, Qing-Yu Zhang, Yin Chen, Zhong Li, Hongmin Li

Publikováno v: Emerging Microbes and Infections, Vol 12, Iss 1 (2023)

ABSTRACTSARS-CoV-2 has caused a global pandemic with significant humanity and economic loss since 2020. Currently, only limited options are available to treat SARS-CoV-2 infections for vulnerable populations. In this study, we report a universal fluo

Externí odkaz: https://doaj.org/article/60c51fd2806c487b8bf9c42761d4bf04

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Akademický článek

Effects of substrate modifications on the arginine dimethylation activities of PRMT1 and PRMT5

Autor: Melody D. Fulton, Tran Dang, Tyler Brown, Y. George Zheng

Publikováno v: Epigenetics, Vol 17, Iss 1, Pp 1-18 (2022)

Histone arginine methylation is a prevalent posttranslational modification (PTM) in eukaryotic cells and contributes to the histone codes for epigenetic regulation of gene transcription. In this study, we determined how local changes on adjacent resi

Externí odkaz: https://doaj.org/article/d699dc005ded4b4988324f64f18e8826

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Akademický článek

PRMT1 is an important factor for medulloblastoma cell proliferation and survival

Autor: Xiao Gu, Miao He, Timofey Lebedev, Cheng-Han Lin, Zhong-Yan Hua, Y. George Zheng, Zhi-Jie Li, Jer-Yen Yang, Xing-Guo Li

Publikováno v: Biochemistry and Biophysics Reports, Vol 32, Iss , Pp 101364- (2022)

Aberrant expression of protein arginine methyltransferases (PRMTs) has been implicated in a number of brain tumors, but the role of PRMT1 in medulloblastoma, the most common malignant pediatric brain tumor, remains unexplored. By examining the public

Externí odkaz: https://doaj.org/article/56667d0b14114780b6106ade308ec567

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Akademický článek

HBO1 catalyzes lysine benzoylation in mammalian cells

Autor: Doudou Tan, Wei Wei, Zhen Han, Xuelian Ren, Cong Yan, Shankang Qi, Xiaohan Song, Y. George Zheng, Jiemin Wong, He Huang

Publikováno v: iScience, Vol 25, Iss 11, Pp 105443- (2022)

Summary: Lysine benzoylation (Kbz) is a newly discovered protein post-translational modification (PTM). This PTM can be stimulated by benzoate and contributes to gene expression. However, its regulatory enzymes and substrate proteins remain largely u

Externí odkaz: https://doaj.org/article/deb5b92a693a475c8c2f0fe0529a482d

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Akademický článek

Methylation of dual-specificity phosphatase 4 controls cell differentiation

Publikováno v: Cell Reports, Vol 36, Iss 4, Pp 109421- (2021)

Summary: Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis

Externí odkaz: https://doaj.org/article/c390eca951f14661aa1b8d2ec69d2ff2

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Akademický článek

Synthesis and Activity of Triazole-Adenosine Analogs as Protein Arginine Methyltransferase 5 Inhibitors

Autor: Tyler Brown, Mengtong Cao, Y. George Zheng

Publikováno v: Molecules, Vol 27, Iss 12, p 3779 (2022)

Protein arginine methyltransferase 5 (PRMT5) is an attractive molecular target in anticancer drug discovery due to its extensive involvement in transcriptional control, RNA processing, and other cellular pathways that are causally related to tumor in

Externí odkaz: https://doaj.org/article/10a7a242fae847f9be8fe00d0b957a3e

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Akademický článek

Lysine benzoylation is a histone mark regulated by SIRT2

Autor: He Huang, Di Zhang, Yi Wang, Mathew Perez-Neut, Zhen Han, Y. George Zheng, Quan Hao, Yingming Zhao

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)

Histone marks regulate chromatin structure and function. Here the authors identify and characterize lysine benzoylation, a histone mark that can be modulated by sodium benzoate, a widely used chemical food preservative, associated with specific regul

Externí odkaz: https://doaj.org/article/746a4a2004154a68b2d8f8e5df4bfa84

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