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Acidosis modifies effects of phosphorylated tropomyosin on the actin-myosin interaction in the myocardium

Autor: Dmitrii I. Levitsky, Valentina Y. Berg, Galina V. Kopylova, Alexander M. Matyushenko, Sergey Y. Bershitsky, D. V. Shchepkin

Publikováno v: Journal of Muscle Research and Cell Motility. 42:343-353

Phosphorylation of α-tropomyosin (Tpm1.1), a predominant Tpm isoform in the myocardium, is one of the regulatory mechanisms of the heart contractility. The Tpm 1.1 molecule has one site of phosphorylation, Ser283. The degree of the Tpm phosphorylati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30b04e0f531bb74fcbd82b5c8658934d
https://doi.org/10.1007/s10974-020-09593-4

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Effects of myopathy-causing mutations R91P and R245G in the TPM3 gene on structural and functional properties of slow skeletal muscle tropomyosin

Autor: Valentina Y. Berg, Alexander M. Matyushenko, Anastasia M. Kochurova, Dmitrii I. Levitsky, Sergey Yu. Kleymenov, Anastasiia D. Gonchar, Andrey K. Tsaturyan, Galina V. Kopylova, Natalia A. Koubasova, D. V. Shchepkin

Publikováno v: Biochemical and Biophysical Research Communications. 534:8-13

Tropomyosin (Tpm) is an actin-binding protein that plays a crucial role in the regulation of muscle contraction. Numerous point mutations in the TPM3 gene encoding Tpm of slow skeletal muscles (Tpm 3.12 or γ-Tpm) are associated with the genesis of v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced1bfa5211e9ae93beedcc3aee2d966
https://doi.org/10.1016/j.bbrc.2020.11.103

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The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ

Autor: Galina V. Kopylova, Valentina Y. Berg, Anastasia M. Kochurova, Alexander M. Matyushenko, Sergey Y. Bershitsky, Daniil V. Shchepkin

Publikováno v: Biochemical and biophysical research communications. 588

The molecular mechanisms of pathogenesis of atrial myopathy associated with hypertrophic (HCM) and dilated (DCM) mutations of sarcomeric proteins are still poorly understood. For this, one needs to investigate the effects of the mutations on actin-my

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa555ee4db74dd709a50b8b08583e267
https://pubmed.ncbi.nlm.nih.gov/34942531

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Differing effects of estrogen deficiency on the contractile function of atrial and ventricular myocardium

Autor: Xenia Butova, D. A. Kuznetsov, Anastasia M. Kochurova, Valentina Y. Berg, Anastasia Khokhlova, Galina V. Kopylova, E. A. Mukhlynina, Denis Volzhaninov, D. V. Shchepkin, Tatiana Myachina

Publikováno v: Biochemical and biophysical research communications. 541

Estrogen deficiency has a significant influence on the excitation-contraction coupling in the ventricular myocardium but its impact on the atrial contractile function has not been studied. We have compared the effects of estrogen deficiency on the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615e03ef5f5fa66a96d8e85c15d8a696
https://pubmed.ncbi.nlm.nih.gov/33461065

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Acidosis modifies effects of phosphorylated tropomyosin on the actin-myosin interaction in the myocardium

Autor: Galina V, Kopylova, Alexander M, Matyushenko, Valentina Y, Berg, Dmitrii I, Levitsky, Sergey Y, Bershitsky, Daniil V, Shchepkin

Publikováno v: Journal of muscle research and cell motility. 42(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64ba2b5c8bcca583016af3f351f8e092
https://pubmed.ncbi.nlm.nih.gov/33389411

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Mechanisms of disturbance of the contractile function of slow skeletal muscles induced by myopathic mutations in the tropomyosin TPM3 gene

Autor: Sergey Yu. Kleymenov, Alexander M. Matyushenko, D. V. Shchepkin, Galina V. Kopylova, Anastasia V. Pivovarova, Victoria V. Nefedova, Valentina Y. Berg, Sergey Y. Bershitsky, Dmitrii I. Levitsky

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(10)

Several congenital myopathies of slow skeletal muscles are associated with mutations in the tropomyosin (Tpm) TPM3 gene. Tropomyosin is an actin-binding protein that plays a crucial role in the regulation of muscle contraction. Two Tpm isoforms, γ (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80db2efaa9b046589c61b2a216e15e11
https://pubmed.ncbi.nlm.nih.gov/32797717

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Myosin from the ventricle is more sensitive to omecamtiv mecarbil than myosin from the atrium

Autor: Valentina Y. Berg, L.V. Nikitina, Sergey Y. Bershitsky, Anastasia M. Kochurova, Galina V. Kopylova, D. V. Shchepkin, S. R. Nabiev

Publikováno v: Biochemical and biophysical research communications. 528(4)

Omecamtiv mecarbil (OM), an activator of cardiac myosin, strongly affects contractile characteristics of the ventricles and, to a much lesser extent, the characteristics of atrial contraction. We compared the molecular mechanism of action of OM on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e35a0203bd55e1317b6fd54817f6dc5
https://pubmed.ncbi.nlm.nih.gov/32513536

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Structural and functional properties of αβ-heterodimers of tropomyosin with myopathic mutations Q147P and K49del in the β-chain

Autor: Valentina Y. Berg, Alexander M. Matyushenko, Denis S. Susorov, Victoria V. Nefedova, Dmitrii I. Levitsky, Galina V. Kopylova, D. V. Shchepkin, Sergey Yu. Kleymenov

Publikováno v: Biochemical and Biophysical Research Communications. 508:934-939

Tropomyosin (Tpm) is an α-helical coiled-coil actin-binding protein that plays a key role in the Ca2+-regulated contraction of striated muscles. Two Tpm isoforms, α (Tpm 1.1) and β (Tpm 2.2), are expressed in fast skeletal muscles. These Tpm isofo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ff748d8de1fa88dc197091bcb3af1d
https://doi.org/10.1016/j.bbrc.2018.12.019

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Mechanical modeling of metal thin films on elastomers for femtosecond laser patterned interconnects

Autor: Yosi Shacham-Diamand, Dov Sherman, I. Turjeman, Tali Dotan, Zvi Kotler, Y. Berg

Publikováno v: Microelectronic Engineering. 241:111534

In this work, we present the mechanical analysis of thin Au/Ti film deposited on elastomer substrate, e.g. Polydimethylsiloxane (PDMS) comparing to samples on Kapton®. After deposition, the metal was patterned by ultrashort (270 femtosecond) pulse l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c2c177625ea4f93899baf660b43420b
https://doi.org/10.1016/j.mee.2021.111534

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A Method for Actin Filament Tracking in Fluorescent Microscopy Images

Autor: Dmitry V. Sorokin, Danil Kononykhin, Valentina Y. Berg, Andrey S. Krylov

Publikováno v: Proceedings of the 30th International Conference on Computer Graphics and Machine Vision (GraphiCon 2020). Part 2. :37-1

The automated tracking of subcellular structures in live microscopy image sequences is an actual problem in many biological research areas. A universal solution for this problem still does not exist due to a huge variety of data of different nature.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::432b7c16a7b1d5c54722f1e144918632
https://doi.org/10.51130/graphicon-2020-2-3-37

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