Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Y Adam Yuan"'
Autor:
Ying Gu, Fang Cao, Lei Wang, Wangheng Hou, Jun Zhang, Choy-leong Hew, Shaowei Li, Y Adam Yuan, Ningshao Xia
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61314 (2013)
Mature HIV-1 viral particles assemble as a fullerene configuration comprising p24 capsid hexamers, pentamers and dimers. In this paper, we report the X-ray crystal structures of the p24 protein from natural HIV-1 strain (BMJ4) in complex with Fab A10
Externí odkaz:
https://doaj.org/article/469a1bc48a634a10aabaaf7bdb646d68
Autor:
Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia, Y. Adam Yuan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Hepatitis B virus X protein (HBx) binds anti-apoptotic Bcl-xL through its BH3-like motif to promote viral replication. Here, the authors provide the structure of the HBx BH3-like domain and Bcl-xL, which shows an unusual mode of interaction, and iden
Externí odkaz:
https://doaj.org/article/bccf1b6cc6fc4a3986b958df99dc247d
Publikováno v:
Biochemistry. 56:6098-6110
In humans, primary microRNA (pri-miRNA) processing starts from precise cleavage of the stem loop, which is catalyzed by the Drosha-DGCR8 complex. However, the significant inconsistencies in the expression levels among primary, precursor, and mature m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e54cf7b167676a3b21e49e03ec0e636
https://doi.org/10.1021/acs.biochem.7b00693
https://doi.org/10.1021/acs.biochem.7b00693
Autor:
Ningshao Xia, Xiaobing Mo, Quan Yuan, Y. Adam Yuan, Tianying Zhang, Hong-Ying Chen, Chenghao Huang, Ding Xue, Xiao-Zhen Kang, Bo Yin, Jing-Hua Zhao, Xiang Zhao, Hualong Xiong, Jiali Cao, Tian-Liang Li
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Hepatitis B virus (HBV) X protein, HBx, interacts with anti-apoptotic Bcl-2 and Bcl-xL proteins through its BH3-like motif to promote HBV replication and cytotoxicity. Here we report the crystal structure of HBx BH3-like motif in complex with Bcl-xL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbae2859933b9285e39bef37771db29c
http://europepmc.org/articles/PMC6642116
http://europepmc.org/articles/PMC6642116
Autor:
Xiangfeng Xi, Y. Adam Yuan, Yan Xiao, Zhe Sun, Xiaobing Mo, Chaochao Lv, Xiangdong Li, Yajie Xuan, Bo Yin, Yuzhou Wang, Qingyuan Yang, Yali Yao, Kegong Tian
Publikováno v:
Journal of Biotechnology. 223:8-12
We report the strategies leading to the large-production of soluble non-tag full-length porcine circovirus type 2 (PCV2) Cap protein in Escherichia coli. Under neutral pH condition, the purified recombinant Cap protein derived from E. coli expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1795d722bce1b51af0a5ce1324d0f3fb
https://doi.org/10.1016/j.jbiotec.2016.02.025
https://doi.org/10.1016/j.jbiotec.2016.02.025
Autor:
Siqi Zhang, Ping Zhou, Zerong Xu, Huanxiang Liu, Yuqing Liu, Shicheng Wei, Xiaohong Zhang, Rui Zhang, Yongliang Li, Y. Adam Yuan, Yubo Yan, Bo Yin
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 171
The ability to obtain a large number of human pluripotent stem cells (hPSCs) under chemically defined conditions plays a key role in clinical application of hPSCs. Chemically defined, economical and effective synthetic peptide displaying surfaces sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa13f6556e20e994a90bf7ed2707b9d
https://pubmed.ncbi.nlm.nih.gov/30075421
https://pubmed.ncbi.nlm.nih.gov/30075421
Autor:
Jun-Fang Zhang, Tong Cheng, James Wk Shih, Xiaobing Mo, Chang-Ru Wu, Cheng-Pu Sun, Guo Xueran, Tianying Zhang, Yali Zhang, Ying Zhang, Quan Yuan, Y. Adam Yuan, Jing-Hua Zhao, Jun Zhang, Mi-Hua Tao, Yu-Chieh Lo, Ningshao Xia, Yixin Chen, Wenxin Luo, Jiali Cao, Ying Lan, Pei-Jer Chen, Xuan Liu, Qinjian Zhao, Lunzhi Yuan
Publikováno v:
Gut. 65:658-671
Objective This study aimed to investigate the therapeutic potential of monoclonal antibody (mAb) against HBV as a novel treatment approach to chronic hepatitis B (CHB) in mouse models. Methods Therapeutic effects of mAbs against various epitopes on v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b383d920267451befacef7e1df4d4a4
https://doi.org/10.1136/gutjnl-2014-308964
https://doi.org/10.1136/gutjnl-2014-308964
Autor:
Jinping Lin, Shuiqin Jiang, Zhiqiang Yao, Lujia Zhang, Dongzhi Wei, Dongbing Cui, Bei Gao, Y. Adam Yuan
Publikováno v:
FEBS Journal. 282:2339-2351
Coenzyme engineering, especially for altered coenzyme specificity, has been a research hotspot for more than a decade. In the present study, a novel computational strategy that enhances the hydrogen-bond interaction between an enzyme and a coenzyme w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e2c2b17fcaeb2b78d40f3da97886e
https://doi.org/10.1111/febs.13282
https://doi.org/10.1111/febs.13282
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 79:410-421
We report the crystal structure of old yellow enzyme (OYE) family protein Gox0502 (a.a 1–315) in free form at 3.3 Å. Detailed structural analysis revealed the key residues involved in stereospecific determination of Gox0502, such as Trp66 and Trp1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652a55be46e1c4f4bb429eabe790cf42
https://doi.org/10.1080/09168451.2014.993355
https://doi.org/10.1080/09168451.2014.993355
Autor:
Jianxing Song, Yee-Joo Tan, Y. Adam Yuan, Garvita Gupta, Qi Zeng, Jianping Wu, Bhaskar Barnwal, Chee-Keng Mok, Vincent T. K. Chow, Mandakhalikar Kedar Diwakar
Publikováno v:
Antiviral Research
Highlights • 2H6-antigen binding fragment forms a multimeric complex with non-structural 1 protein. • 2H6 antibody binds tightly to non-structural 1 protein. • The binding affinity reduces significantly when threonine 49 is substituted with Ala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7726049b1065738afb059ddf31a1427
http://europepmc.org/articles/PMC7113856
http://europepmc.org/articles/PMC7113856