Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Y A, DeClerck"'
Autor:
R, Moats, L Q, Ma, R, Wajed, Y, Sugiura, A, Lazaryev, M, Tyszka, R, Jacobs, S, Fraser, M D, Nelson, Y A, DeClerck
Publikováno v:
Clinicalexperimental metastasis. 18(6)
Neuroblastoma is the second most common solid tumor in children. So far few tumor models for this cancer have been reported in mice. We have created a murine tumor model for studying human neuroblastoma based on surgical orthotopic implantation in sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50387568e74fdb8a368a7c6fd99bdaff
https://pubmed.ncbi.nlm.nih.gov/11592302
https://pubmed.ncbi.nlm.nih.gov/11592302
Publikováno v:
Annals of the New York Academy of Sciences. 878
Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a5d28cfe5a757ace0bdb4b6f1c9a2ba
https://pubmed.ncbi.nlm.nih.gov/10415723
https://pubmed.ncbi.nlm.nih.gov/10415723
Publikováno v:
Cancer research. 59(6)
Proteases of the plasminogen-plasminogen activator (PA) system play an important role in cancer metastasis. We have examined the expression of these proteases and their cell surface receptors and inhibitors in neuroblastoma, a tumor that originates i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6f35b30561a32ad3c0d47e367c77fee
https://pubmed.ncbi.nlm.nih.gov/10096567
https://pubmed.ncbi.nlm.nih.gov/10096567
Publikováno v:
Journal of neuro-oncology. 40(3)
The plasminogen activation (PA) system plays an important role in tumor invasion by initiating pericellular proteolysis of the extracellular matrix (ECM) and inducing cell migration. Malignant brain tumors overexpress PA members and characteristicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efc5c6f002731e1ccd66f1bc65b76eb1
https://pubmed.ncbi.nlm.nih.gov/10066093
https://pubmed.ncbi.nlm.nih.gov/10066093
Autor:
C M, Overall, A E, King, D K, Sam, A D, Ong, T T, Lau, U M, Wallon, Y A, DeClerck, J, Atherstone
Publikováno v:
The Journal of biological chemistry. 274(7)
Cell surface activation of progelatinase A occurs in a quaternary complex with the tissue inhibitor of metalloproteinases-2 (TIMP-2) and two membrane-type matrix metalloproteinases. We have mutated the unique cationic clusters found in hemopexin modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e26600fd19a44e2f33b34f6c5f0764d
https://pubmed.ncbi.nlm.nih.gov/9933646
https://pubmed.ncbi.nlm.nih.gov/9933646
Publikováno v:
Advances in experimental medicine and biology. 425
Our understanding of the role of matrix degrading proteases in cancer has dramatically expanded over the last two decades. From correlative observations linking proteases to cancer progression, we have accumulated evidence supporting a causal role fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ffe66cae35d911f9a6f0b02fc7347ae
https://pubmed.ncbi.nlm.nih.gov/9433492
https://pubmed.ncbi.nlm.nih.gov/9433492
Publikováno v:
Journal of cellular physiology. 167(2)
Serine proteases and matrix metalloproteinases have been shown to often cooperate in multiple physiological and pathological processes associated with changes in the extracellular matrix (ECM). We have examined the interaction between the plasminogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d131ae82a6d456e2a9a723ef592c806
https://pubmed.ncbi.nlm.nih.gov/8613475
https://pubmed.ncbi.nlm.nih.gov/8613475
Publikováno v:
Cancer research. 54(20)
In this study, we examined the effect of expression of tissue inhibitor of metalloproteinases-2 (TIMP-2) on the growth and dissemination of a highly metastatic human melanoma cell line (M24net). M24net melanoma cells express a number of matrix metall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5fa65303b3874cb5d869c2510fbf50ce
https://pubmed.ncbi.nlm.nih.gov/7923181
https://pubmed.ncbi.nlm.nih.gov/7923181
Publikováno v:
Cancer research. 52(3)
The balance between levels of metalloproteinases and their corresponding inhibitors is a critical factor in tumor invasion and metastasis. Down-regulation of the activity of these proteases was achieved by transfection of invasive and metastatic rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1979ef71864d8d0d54fb754a8c0be3df
https://pubmed.ncbi.nlm.nih.gov/1732058
https://pubmed.ncbi.nlm.nih.gov/1732058
Publikováno v:
Cancer research. 51(8)
Matrix metalloproteinases secreted by tumor cells play an important role in the proteolytic degradation of the extracellular matrix during invasion. In a previous study, we showed that the degradation of extra-cellular matrices by human HT 1080 fibro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43dd0f4fbf76096995b262e25634199e
https://pubmed.ncbi.nlm.nih.gov/2009533
https://pubmed.ncbi.nlm.nih.gov/2009533