Výsledky vyhledávání - "Y A, De Clerck"

Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)

Autor: Y A De Clerck, Martine I. Darville, Yves Eeckhout, Guy G. Rousseau

Publikováno v: Gene. 139:185-191

Tissue inhibitors of metalloproteinases (TIMPs) are multifunctional proteins that control the proteolytic activity of matrix metalloproteinases (MMPs). We report here the cloning and characterization of a 2.5-kb genomic fragment of the human timp-2 g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4fd2c0d25dee2493da3750fd6d1321
https://doi.org/10.1016/0378-1119(94)90753-6

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cDNA cloning and expression of a metalloproteinase inhibitor related to tissue inhibitor of metalloproteinases

Autor: Y A De Clerck, Keith Langley, Thomas C. Boone, M J Johnson

Publikováno v: Proceedings of the National Academy of Sciences. 87:2800-2804

The purification and characterization of a metalloproteinase inhibitor (MI) from bovine aortic endothelial cells, and the demonstration that it is related to, but distinct from, tissue inhibitor of metalloproteinase (TIMP), have previously been repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e7434bdd6f4cf738615d1e7f2e43a2
https://doi.org/10.1073/pnas.87.7.2800

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The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25

Autor: Y A De Clerck, Magdy Sayed Aly, Jean Jacques Cassiman, Claude Szpirer, Yves Eeckhout, Guy G. Rousseau

Publikováno v: Genomics. 14:782-784

Tissue inhibitor of metalloproteinases-2 (TIMP2) is a natural inhibitor of several proteinases that are involved in the degradation of the extracellular matrix. By means of somatic cell hybrids segregating human chromosomes, the gene encoding this in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf6eb816da7e2acd7a18dfffccfc416
https://doi.org/10.1016/s0888-7543(05)80186-7

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Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2

Autor: P J Williams, F Bauss, T Yoneda, Y A De Clerck, Gregory R. Mundy, Colin R. Dunstan, Akira Sasaki

Publikováno v: Scopus-Elsevier

Multiple steps are involved in the metastasis of cancer cells from primary sites to distant organs. These steps should be considered in the design of pharmacologic approaches to prevent or inhibit the metastatic process. In the present study, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da05bbee5cab049e5d816ea713b491c
https://europepmc.org/articles/PMC508092/

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Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis

Autor: M, Trikha, Y A, De Clerck, F S, Markland

Publikováno v: Cancer research. 54(18)

Disintegrins are Arg-Gly-Asp-containing proteins that inhibit integrin-mediated cell-cell and cell-matrix interactions. We have purified a disintegrin, contortrostatin, from Agkistrodon contortrix contortrix snake venom that is a potent inhibitor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b2bd4d0bbee57f7dd089c541a009979f
https://pubmed.ncbi.nlm.nih.gov/7520832

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Tissue inhibitors of metalloproteinases: role in tumor progression

Autor: Y A, De Clerck, O, Alvarez, H, Shimada, S M, Taylor, K E, Langley

Publikováno v: Contributions to nephrology. 107

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a87a1ff8ac4ae8dc9436ce3fea5bcbd
https://pubmed.ncbi.nlm.nih.gov/8004956

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Melanoma-mediated dissolution of extracellular matrix: contribution of urokinase-dependent and metalloproteinase-dependent proteolytic pathways

Autor: A M, Montgomery, Y A, De Clerck, K E, Langley, R A, Reisfeld, B M, Mueller

Publikováno v: Cancer research. 53(3)

Constitutive overexpression of both urokinase and matrix metalloproteinase (MMP) activity is frequently observed in individual malignant tumors. In this study we describe the combined contribution of these distinct enzyme systems to the invasive phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::23e47e0af297ac39ddc11461db2c9771
https://pubmed.ncbi.nlm.nih.gov/8425205

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Purification and Characterization of Two Related but Distinct Metalloproteinase Inhibitors Secreted by Bovine Aortic Endothelial Cells

Autor: Y A De Clerck, Keith Langley, T D Yean, B J Ratzkin, H S Lu

Publikováno v: Scopus-Elsevier

Two metalloproteinase inhibitors were purified from serum-free medium conditioned by bovine aortic endothelial cells. One of these inhibitors, with a molecular weight of 30,000-34,000 (reduced) is identified as tissue inhibitor of metalloproteinases;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6677b6dee1b566fd7b55c6ed3436778
https://doi.org/10.1016/s0021-9258(18)71515-9

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Invasive properties of primary pediatric neoplasms in vitro

Autor: E, Bogenmann, C, Mark, H, Isaacs, H B, Neustein, Y A, De Clerck, W E, Laug, P A, Jones

Publikováno v: Cancer research. 43(3)

Primary solid tumors were mechanically and/or enzymatically disassociated, and the resulting suspensions of single cells and small clumps of cells were seeded onto three different substrates, i.e., tissue culture plastic, rat smooth muscle cells (SMC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b720086a37a6837ed5967b4d35c065d
https://pubmed.ncbi.nlm.nih.gov/6297720

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