Identification of anti-inflammatory and anti-cancer compounds targeting the NF-κB-NLRP3 inflammasome pathway from a phytochemical library of the Sideritis genus.

Autor: Yücer R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address: ryuecer@students.uni-mainz.de., Schröder A; Theophrastus Paracelsus Foundation, 64367, Mühltal, Germany. Electronic address: angela.schroeder@zuv.uni-heidelberg.de., Topçu G; Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkiye; Drug Application & Research Center (DARC), Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkiye. Electronic address: gtopcu@bezmialem.edu.tr., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address: efferth@uni-mainz.de.

Publikováno v: Journal of ethnopharmacology [J Ethnopharmacol] 2024 Nov 09; Vol. 338 (Pt 2), pp. 119074. Date of Electronic Publication: 2024 Nov 09.

The cytotoxic activities of the major diterpene extracted from Salvia multicaulis (Bardakosh) are mediated by the regulation of heat-shock response and fatty acid metabolism pathways in human leukemia cells.

Autor: Nabih HK; National Research Centre, Medical Biochemistry Department, 33 El-Bohouth St., Dokki, Giza 12622, Egypt., Yücer R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Mahmoud N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Dawood M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany; Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan., Elbadawi M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Shahhamzehei N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Atia MAM; Molecular Genetics and Genome Mapping Laboratory, Genome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center (ARC), Giza 12619, Egypt., AbdelSadik A; Zoology Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt; Molecular Biotechnology Program, Faculty of Advanced Basic Sciences, Galala University, 43552, New Galala, Egypt., Hussien TA; Pharmacognosy Department, Faculty of Pharmacy, Sphinx University, New Assiut City, Assiut 10, Egypt., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt; School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa., Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Hegazy MF; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany; National Research Centre, Chemistry of Medicinal Plants Department, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. Electronic address: mohegazy@uni-mainz.de., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address: efferth@uni-mainz.de.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Sep 27; Vol. 135, pp. 156023. Date of Electronic Publication: 2024 Sep 27.

Cytotoxicity of dioncophylline A and related naphthylisoquinolines in leukemia cells, mediated by NF-κB inhibition, angiogenesis suppression, G2/M cell cycle arrest, and autophagy induction.

Autor: Yücer R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany., Fayez S; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany; Home address: Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt., Feineis D; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany., Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ) Heidelberg, National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Hospital Heidelberg, Germany., Shan L; The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310053, China., Bringmann G; Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany., Dawood M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany. Electronic address: modawood@uni-mainz.de.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Apr; Vol. 126, pp. 155267. Date of Electronic Publication: 2023 Dec 08.

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Sideritis stricta ve Sideritis congesta Bitkilerinin Antikolinesteraz Aktivitelerinin İncelenmesi

Autor: Yücer, Rümeysa, BÜTÜN, BURCU, TOPÇU, GÜLAÇTI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______9651::b327fdebafbd0964f19b0beef7338ac0
https://hdl.handle.net/20.500.12645/246