Výsledky vyhledávání - "Yáiza, Núñez"

Akademický článek

A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice

Autor: Aïda Falgàs, Annabel Garcia-León, Yáiza Núñez, Naroa Serna, Laura Sánchez-Garcia, Ugutz Unzueta, Eric Voltà-Durán, Marc Aragó, Patricia Álamo, Lorena Alba-Castellón, Jorge Sierra, Alberto Gallardo, Antonio Villaverde, Esther Vázquez, Ramon Mangues, Isolda Casanova

Publikováno v: Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112940- (2022)

High rates of relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients and life-threatening side effects associated with immunochemotherapy make an urgent need to develop new therapies for DLBCL patients. Immunotoxins seem very potent a

Externí odkaz: https://doaj.org/article/48b64a5a2e364d00bfca4db18c016d49

Zobrazit plný text záznamu

Akademický článek

T22-PE24-H6 Nanotoxin Selectively Kills CXCR4-High Expressing AML Patient Cells In Vitro and Potently Blocks Dissemination In Vivo

Autor: Yáiza Núñez, Annabel Garcia-León, Aïda Falgàs, Naroa Serna, Laura Sánchez-García, Ana Garrido, Jorge Sierra, Alberto Gallardo, Ugutz Unzueta, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Isolda Casanova

Publikováno v: Pharmaceutics, Vol 15, Iss 3, p 727 (2023)

Despite advances in the development of targeted therapies for acute myeloid leukemia (AML), most patients relapse. For that reason, it is still necessary to develop novel therapies that improve treatment effectiveness and overcome drug resistance. We

Externí odkaz: https://doaj.org/article/64a89ba3101d4368935e446254b12093

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials

Autor: Naroa Serna, Aïda Falgàs, Annabel García-León, Ugutz Unzueta, Yáiza Núñez, Alejandro Sánchez-Chardi, Carlos Martínez-Torró, Ramón Mangues, Esther Vazquez, Isolda Casanova, Antonio Villaverde

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 192 (2022)

The sustained release of small, tumor-targeted cytotoxic drugs is an unmet need in cancer therapies, which usually rely on punctual administration regimens of non-targeted drugs. Here, we have developed a novel concept of protein–drug nanoconjugate

Externí odkaz: https://doaj.org/article/388ee8da4cd04eafb47d18c0533955fc

Zobrazit plný text záznamu

Plný text ve formátu HTML

A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4

Autor: Aïda, Falgàs, Annabel, Garcia-León, Yáiza, Núñez, Naroa, Serna, Laura, Sánchez-Garcia, Ugutz, Unzueta, Eric, Voltà-Durán, Marc, Aragó, Patricia, Álamo, Lorena, Alba-Castellón, Jorge, Sierra, Alberto, Gallardo, Antonio, Villaverde, Esther, Vázquez, Ramon, Mangues, Isolda, Casanova

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 150

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b6345d64207f591b9919aba1aab23207
https://pubmed.ncbi.nlm.nih.gov/35421785

Zobrazit plný text záznamu

A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model

Autor: Annabel García-León, Anna Aviñó, Ramon Eritja, Laura Sánchez-García, Ugutz Unzueta, Aïda Falgàs, Naroa Serna, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Victor Pallarès, Lídia Cedó, Lorena Alba-Castellón, Ramon Mangues, Jorge Sierra, Alberto Gallardo, Yáiza Núñez, Patricia Álamo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
BIOMATERIALS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau

Current therapy in acute myeloid leukemia (AML) is based on chemotherapeutic drugs administered at high doses, lacking targeting selectivity and displaying poor therapeutic index because of severe adverse effects. Here, we develop a novel nanoconjuga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2df53b326284dc6f8e01b78c7dd7e3
https://ddd.uab.cat/record/263131

Zobrazit plný text záznamu

Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4 + Diffuse Large B-Cell Lymphoma Cells

Autor: Jorge Sierra, Yáiza Núñez, Aïda Falgàs, Patricia Álamo, Ugutz Unzueta, Maria Antonia Mangues, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Victor Pallarès, Ramon Mangues, Alberto Gallardo, Lorena Alba-Castellón

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
International Journal of Nanomedicine, Vol Volume 16, Pp 1869-1888 (2021)
International Journal of Nanomedicine
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Aïda Falgàs,1– 3 Victor Pallarès,1– 3 Ugutz Unzueta,1– 4 Yáiza Núñez,1,2 Jorge Sierra,2,5 Alberto Gallardo,1 Lorena Alba-Castellón,1,2 Maria Antonia Mangues,3,6 Patricia Álamo,1– 3 Antonio Villaverde,3,4,7 Esther Vázquez,3,4,7 Ramon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf2c676c4fb367fc146d5b0f85cc075
https://ddd.uab.cat/record/255355

Zobrazit plný text záznamu

Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4

Autor: Lorena Alba-Castellón, Ramon Mangues, Laura Sánchez-García, Victor Pallarès, Yáiza Núñez, Patricia Álamo, Naroa Serna, Alberto Gallardo, Ugutz Unzueta, Aïda Falgàs, Antonio Villaverde, Esther Vázquez, Isolda Casanova, Jorge Sierra

Publikováno v: JOURNAL OF CONTROLLED RELEASE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Nanomedicine has opened an opportunity to improve current clinical practice by enhancing the selectivity in the delivery of antitumor drugs to specific cancer cells. These new strategies are able to bypass toxicity on normal cells increasing the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302566e8d2d9bf5d6ad422387ea39ebe
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4499

Zobrazit plný text záznamu

Specific Cytotoxic Effect of an Auristatin Nanoconjugate Towards CXCR4

Autor: Aïda, Falgàs, Victor, Pallarès, Ugutz, Unzueta, Yáiza, Núñez, Jorge, Sierra, Alberto, Gallardo, Lorena, Alba-Castellón, Maria Antonia, Mangues, Patricia, Álamo, Antonio, Villaverde, Esther, Vázquez, Ramon, Mangues, Isolda, Casanova

Publikováno v: International Journal of Nanomedicine

Background and Purpose Around 40–50% of diffuse large-B cell lymphoma (DLBCL) patients suffer from refractory disease or relapse after R-CHOP first-line treatment. Many ongoing clinical trials for DLBCL patients involve microtubule targeting agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f82db308fa47c2f377dd027700ec56a
https://pubmed.ncbi.nlm.nih.gov/33716502

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání