Mesenchymal stromal cell therapies for traumatic neurological injuries.

Autor: Wang, Xiujuan¹ (AUTHOR), Wang, Qian^2,3 (AUTHOR), Xia, Ziyao^4,5 (AUTHOR), Yang, Ying¹ (AUTHOR), Dai, Xunan⁵ (AUTHOR), Zhang, Chun^4,5 (AUTHOR) zhangc1@yahoo.com, Wang, Jiaxian^2,3 (AUTHOR) wangjx@helptx.com.cn, Xu, Yongsheng^1,5 (AUTHOR) xys1214@163.com

Publikováno v: Journal of Translational Medicine. 11/22/2024, Vol. 22 Issue 1, p1-18. 18p.

The Current Status of Mesenchymal Stromal Cells: Controversies, Unresolved Issues and Some Promising Solutions to Improve Their Therapeutic Efficacy.

Autor: García-Bernal D; Hematopoietic Transplant and Cellular Therapy Unit, Medicine Department, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca, University of Murcia, Murcia, Spain.; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain., García-Arranz M; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain., Yáñez RM; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., Hervás-Salcedo R; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., Cortés A; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas and Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid, Spain., Fernández-García M; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., Hernando-Rodríguez M; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., Quintana-Bustamante Ó; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., Bueren JA; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., García-Olmo D; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain., Moraleda JM; Hematopoietic Transplant and Cellular Therapy Unit, Medicine Department, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca, University of Murcia, Murcia, Spain.; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain., Segovia JC; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Advanced Therapies Mixed Unit, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD, Autonomous University of Madrid (UAM)), Madrid, Spain.; Centre for Cytometry and Fluorescence Microscopy, Complutense University, Madrid, Spain., Zapata AG; Spanish Network of Cell Therapy (TerCel), Instituto de Salud Carlos III, Madrid, Spain.; Department of Cell Biology, Complutense University, Madrid, Spain.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Mar 16; Vol. 9, pp. 650664. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2021).

Combination of bone marrow mesenchymal stem cells and moxibustion restores cyclophosphamide-induced premature ovarian insufficiency by improving mitochondrial function and regulating mitophagy.

Autor: Lu, Ge¹ (AUTHOR), Li, Hong-xiao¹ (AUTHOR), Song, Zi-wei¹ (AUTHOR), Luo, Jia¹ (AUTHOR), Fan, Yan-liang¹ (AUTHOR), Yin, Yao-li¹ (AUTHOR) 270557@njucm.edu.cn, Shen, Jie¹ (AUTHOR) 270987@njucm.edu.cn, Shen, Mei-hong^1,2 (AUTHOR) mhshen@njucm.edu.cn

Publikováno v: Stem Cell Research & Therapy. 4/8/2024, Vol. 15 Issue 1, p1-18. 18p.

The nuclei of human adult stem cells can move within the cell and generate cellular protrusions to contact other cells.

Autor: Bueno, Carlos¹ (AUTHOR) carlos.bueno@um.es, García-Bernal, David^1,2 (AUTHOR), Martínez, Salvador^3,4,5 (AUTHOR), Blanquer, Miguel¹ (AUTHOR), Moraleda, José M.¹ (AUTHOR)

Publikováno v: Stem Cell Research & Therapy. 2/27/2024, Vol. 15 Issue 1, p1-16. 16p.

Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: results from open-label phase 1/2 (FANCOLEN-1) and long-term clinical trials.

Autor: Río P; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Zubicaray J; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Pediatric Hematology and Oncology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; Foundation for the Biomedical Research, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Navarro S; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Gálvez E; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Pediatric Hematology and Oncology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; Foundation for the Biomedical Research, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Sánchez-Domínguez R; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Nicoletti E; Rocket Pharmaceuticals, Cranbury, NJ, USA., Sebastián E; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Pediatric Hematology and Oncology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; Foundation for the Biomedical Research, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Rothe M; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Pujol R; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Institut de Recerca Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain; Unit of Genomic Medicine, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Bogliolo M; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Institut de Recerca Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain; Serra Hunter Fellow, Department of Genetics and Microbiology, Faculty of Biosciences, Universitat Autònoma de Barcelona, Barcelona, Spain; Unit of Genomic Medicine, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., John-Neek P; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Bastone AL; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Wang W; Genwerk, Heidelberg, Germany., Schmidt M; Genwerk, Heidelberg, Germany., Larcher L; Université Paris Cité, Inserm, CNRS, Hôpital Saint-Louis, APHP, Paris, France., Segovia JC; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Yáñez RM; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Alberquilla O; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Díez B; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Fernández-García M; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., García-García L; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain., Ramírez M; Pediatric Hematology and Oncology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; Sanitary Research Institute Fundación La Princesa, Madrid, Spain., Galy A; Genethon, UMR_S951, Université Paris-Saclay, Univ Evry, Inserm, Evry-Courcouronnes, France., Lefrere F; Hôpital Universitaire Necker Enfants-Malades, Assistance Publique Hôpitaux de Paris GHU Paris Centre, Université Paris Cité, Paris, France; Centre D'Investigation Clinique en Biotherapie INSERM, Institut Imagine, Paris, France., Cavazzana M; Hôpital Universitaire Necker Enfants-Malades, Assistance Publique Hôpitaux de Paris GHU Paris Centre, Université Paris Cité, Paris, France; Centre D'Investigation Clinique en Biotherapie INSERM, Institut Imagine, Paris, France., Leblanc T; Robert-Debré University Hospital (APHP and Université Paris Cité), Paris, France., García de Andoin N; Donostia Universitary Hospital, San Sebastián, Spain; Biogipuzkoa Health Research Institute, San Sebastián, Spain., López-Almaraz R; Cruces Universitary Hospital, Barakaldo, Spain; Biocruces Bizkaia Health Research Institute, Barakaldo, Spain., Catalá A; Hospital Sant Joan de Déu, Barcelona, Spain; Research Institute Sant Joan de Déu, Barcelona, Spain., Barquinero J; Vall d'Hebron Institut de Recerca, Barcelona, Spain., Rodríguez-Perales S; Spanish National Cancer Research Centre (CNIO), Madrid, Spain., Rao G; Rocket Pharmaceuticals, Cranbury, NJ, USA., Surrallés J; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Institut de Recerca Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain; Unit of Genomic Medicine, Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Soulier J; Université Paris Cité, Inserm, CNRS, Hôpital Saint-Louis, APHP, Paris, France., Díaz-de-Heredia C; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Vall d'Hebron Institut de Recerca, Barcelona, Spain; Pediatric Haematology and Oncology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Schwartz JD; Rocket Pharmaceuticals, Cranbury, NJ, USA., Sevilla J; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Pediatric Hematology and Oncology Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain; Foundation for the Biomedical Research, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Bueren JA; Biomedical Innovation Unit, Center for Research on Energy, Environment and Technology (CIEMAT), Madrid, Spain; Biomedical Network Research Center for Rare Diseases (CIBERER), Madrid, Spain; Sanitary Research Institute Fundación Jiménez Díaz (U.A.M), Madrid, Spain. Electronic address: juan.bueren@ciemat.es.

Publikováno v: Lancet (London, England) [Lancet] 2025 Dec 21; Vol. 404 (10471), pp. 2584-2592. Date of Electronic Publication: 2024 Dec 03.