Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans

Autor: Adam F. Cohen, CJ Molloy, D Cerneus, Marieke Liem-Moolenaar, KH Brown, J. Burggraaf, D End, ML de Kam, Y van Hensbergen

Publikováno v: Clinical Pharmacology & Therapeutics. 84:481-487

RWJ-800088 is a novel thrombopoietin mimetic peptide for the treatment of thrombocytopenia. The objectives of this study were to evaluate the pharmacokinetics, pharmacodynamics, and safety of ascending doses of RWJ-800088 administered as a single int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235810444b2a9751e5ced6a49792c762
https://doi.org/10.1038/clpt.2008.96

A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour

Autor: H.M. Pinedo, A. H. G. Hansma, P. J. Van Diest, Klaas Hoekman, Sybren L. Meijer, Roeland Hanemaaijer, Y. Van Hensbergen, Bart C. Kuenen

Publikováno v: Journal of Clinical Pathology, 57(5), 536-538. BMJ Publishing Group
Hansma, A H G, van Hensbergen, Y, Kuenen, B C, van Diest, P J, Hanemaaijer, R, Meijer, S, Pinedo, H M & Hoekman, K 2004, ' A patient with a VEGF and endostatin producing gastrointestinal autonomic nerve tumour ', Journal of Clinical Pathology, vol. 57, no. 5, pp. 536-538 . https://doi.org/10.1136/jcp.2003.012393

Tumour associated neovascularisation has been characterised as chaotic and insufficient. This report details the results of the analysis of angiogenic factors in tumour cyst fluid, pleural fluid, and blood from a patient with a gastrointestinal auton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4c440c7122fe15e33a9cda3d679a33
https://hdl.handle.net/1871/20382

SAT0179 Ready to Use CE-IVD Smart Elisa Kits from Sanquin for Infliximab and Adalimumab Levels Correlate with the Golden Standard and can be Used for Optimisation of Personalised Treatment in RA Patients

Autor: H. te Velthuis, Y. van Hensbergen

Publikováno v: Annals of the Rheumatic Diseases. 74:719.2-720

Background An increasing number of studies indicate that the success of treatment with anti-TNF therapy in RA patients depends on circulating levels of these drugs. For (cost-) effective and safe treatment, assays to reliably measure drug levels in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::049111865cf593e1c2076b8d6dfcfb40
https://doi.org/10.1136/annrheumdis-2015-eular.4729

Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines

Autor: B, van Triest, H M, Pinedo, Y, van Hensbergen, K, Smid, F, Telleman, P S, Schoenmakers, C L, van der Wilt, J A, van Laar, P, Noordhuis, G, Jansen, G J, Peters

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(3)

Thymidylate synthase (TS), a critical enzyme in the de novo synthesis of thymidylate, is an important target for fluoropyrimidines and folate-based TS inhibitors. In a panel of 13 nonselected human colon cancer cell lines, we evaluated the role of TS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2d5329e68b4671b58271f701f467840
https://pubmed.ncbi.nlm.nih.gov/10100718

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