Výsledky vyhledávání

Comparative pharmacokinetic/pharmacodynamic analysis of proton pump inhibitors omeprazole, lansoprazole and pantoprazole, in humans

Autor: Y. Tokuma, Koujirou Yamamoto, Masataka Katashima, T. Hata, Tatsuji Iga, Yasufumi Sawada

Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics. 23:19-26

The relationship between plasma concentrations and inhibitory effects on gastric acid secretion by proton pump inhibitors (PPIs) omeprazole (OPZ), lansoprazole (LPZ) and pantoprazole (PPZ), was analyzed using a pharmacokinetic/pharmacodynamic (PK/PD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87db5045b2e792e407c899094a0034c
https://doi.org/10.1007/bf03189822

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Sex-dependent and independent renal excretion of nilvadipine metabolites in rat: evidence for a sex-dependent active secretion in kidney

Autor: Shigeyuki Terashita, S. Deguchi, T. Hata, Y. Tokuma, T. Sawamoto

Publikováno v: Xenobiotica. 25:37-47

1. To clarify the mechanism of sex-dependent and independent kidney secretion of major nilvadipine metabolites (3, 7) in rat, renal clearance corrected for protein binding and glomerular filtration rate (GFR) was measured in both sexes. The effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73da3e8978e2a73400663fd1a8689e45
https://doi.org/10.3109/00498259509061831

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Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A

Autor: T, Niwa, T, Shiraga, Y, Mitani, M, Terakawa, Y, Tokuma, A, Kagayama

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(9)

Stereoselective metabolism of cibenzoline succinate, an oral antiarrhythmic drug, was investigated on hepatic microsomes from humans and rats and microsomes from cells expressing human cytochrome P450s (CYPs). Four main metabolites, M1 (p-hydroxycibe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b586d41545b326905120664efce90af
https://pubmed.ncbi.nlm.nih.gov/10950860

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Pharmacokinetic and pharmacodynamic study of a new nonsteroidal 5 alpha-reductase inhibitor, 4-[3-[3-[Bis(4-isobutylphenyl)methylamino]benzoyl]-1H-indol-1-yl]-butyr ic acid, in rats

Autor: M, Katashima, K, Yamamoto, Y, Tokuma, T, Hata, Y, Sawada, T, Iga

Publikováno v: The Journal of pharmacology and experimental therapeutics. 284(3)

The pharmacokinetic and pharmacodynamic behaviors of 4-[3-[3-[Bis(4-isobutylphenyl) methylamino] benzoyl]-1H-indol-1-yl]-butyric acid (FK143), a new nonsteroidal steroid 5 alpha-reductase inhibitor, in the ventral prostate were investigated after i.v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cef8bbf551b8e7941790175f5fda9e4b
https://pubmed.ncbi.nlm.nih.gov/9495849

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Tissue distribution kinetics of a new nonsteroidal 5 alpha-reductase [correction of 5 A-reductase] inhibitor, 4-[3-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]-1H-indol-1-YL ]-butyric acid, in rats

Autor: M, Katashima, K, Yamamoto, K, Haraguchi, Y, Tokuma, T, Hata, Y, Sawada, T, Iga

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(9)

The disposition of a new nonsteroidal 5alpha-reductase inhibitor, 4-[3-[3-[bis(4-isobutylphenyl)methylamino]benzoyl]-1H-indol-1-yl]-butyric acid (FK143), was investigated in rats. After intravenous administration of FK143 at 1 and 5 mg/kg, total body

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77a398e7bdda23f518156c60a9682b96
https://pubmed.ncbi.nlm.nih.gov/9311620

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A species comparison of 14C-labeled 7-ethoxycoumarin metabolism in precision-cut liver slices from guinea pig and dog using a phosphor imaging system

Autor: T, Terada, H, Kaneko, S, Terashita, Z, Tozuka, Y, Tokuma, T, Hata

Publikováno v: Research communications in molecular pathology and pharmacology. 91(1)

The metabolism of 14C-labeled 7-ethoxycoumarin (7EC) has been investigated in precision-cut liver slices from guinea pigs and dogs. 7EC was incubated with slices in 12-well plates (4 slices/well; n = 3) for up to 8 hr. In addition, a new simple metho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::801b4a4768802d7788a3e36deee50bad
https://pubmed.ncbi.nlm.nih.gov/8824930

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Interaction of renal excretion between nilvadipine metabolites, M3 and M7 in rats: characterization of sex-dependent and sex-independent active secretion in the kidney

Autor: S, Terashita, T, Sawamoto, Z, Tozuka, Y, Tokuma, T, Hata

Publikováno v: Research communications in molecular pathology and pharmacology. 86(2)

The interaction of renal clearance between nilvadipine metabolites, M3 and M7, in male and female rats including protein binding and renal excretion was investigated to clarify the mechanisms involved. In male rats, active renal secretion of M7 (the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96c49693b6dca677198786c1228128a7
https://pubmed.ncbi.nlm.nih.gov/7881869

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Effects of twenty-three drugs on the metabolism of FK506 by human liver microsomes

Autor: K, Iwasaki, H, Matsuda, K, Nagase, T, Shiraga, Y, Tokuma, K, Uchida

Publikováno v: Research communications in chemical pathology and pharmacology. 82(2)

We investigated the effects of 23 drugs on the metabolism of FK506 by human liver microsomes. Acyclovir, amphotericin B, cefixime, cefotaxime, ciprofloxacin, cyclosporin A, diltiazem, enoxacin, erythromycin, ethinyl estradiol, fluconazole, fosfomycin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d15de654580deadb52e48fb8c3a3293
https://pubmed.ncbi.nlm.nih.gov/7508138

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