Growth arrest-specific protein 6 deficiency impairs liver tissue repair after acute toxic hepatitis in mice

Autor: Fouad Lafdil, Marie-Noële Chobert, Vanessa Deveaux, P. Mavier, Toru Nakano, Y. Laperche, Elie-Serge Zafrani, Arthur Brouillet

Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2009, 51 (1), pp.55-66. ⟨10.1016/j.jhep.2009.02.030⟩

International audience; BACKGROUND/AIMS: Resident macrophages and myofibroblasts derived from hepatic stellate cells play a key role in liver wound healing. We previously reported that these sinusoidal cells secrete the growth arrest-specific protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfb219286cfd8f8b269a21bb38caee8
https://doi.org/10.1016/j.jhep.2009.02.030

Liver precursor cells increase hepatic fibrosis induced by chronic carbon tetrachloride intoxication in rats.: LPC aggravates liver CCl4-induced fibrosis

Autor: Agnès Fourcot, Y. Laperche, Arthur Brouillet, Marie-Noële Chobert, Dominique Couchie, P. Mavier, Elie-Serge Zafrani

Publikováno v: Laboratory Investigation
Laboratory Investigation, Nature Publishing Group, 2012, 92 (1), pp.135-50. ⟨10.1038/labinvest.2011.143⟩
Laboratory Investigation, 2012, 92 (1), pp.135-50. ⟨10.1038/labinvest.2011.143⟩

International audience; Hepatic fibrosis, the major complication of virtually all types of chronic liver damage, usually begins in portal areas, and its severity has been correlated to liver progenitor cells (LPC) expansion from periportal areas, eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf54c1eb7cb77bba688c4a3db6ce7a5
https://www.hal.inserm.fr/inserm-00665625/document

Induction of Gas6 protein in CCl4-induced rat liver injury and anti-apoptotic effect on hepatic stellate cells

Autor: Fouad Lafdil, Dominique Couchie, P. Mavier, Marie Noële Chobert, Arthur Brouillet, Elie Serge Zafrani, Y. Laperche

Publikováno v: Hepatology (Baltimore, Md.). 44(1)

The protein product of the growth arrest-specific gene 6 (Gas6) is a secreted ligand for tyrosine kinase receptors, among which Axl is the most widely distributed and displays the highest affinity for Gas6. The Gas6/Axl signaling pathway has been inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05249fa5930b1ce55fbf9c3a22b75870
https://pubmed.ncbi.nlm.nih.gov/16799993

Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat

Autor: Dominique Couchie, Nadine Martin, Elie Serge Zafrani, P. Mavier, Y. Laperche, Anne-Marie Préaux

Publikováno v: The American journal of pathology. 165(6)

Stromal cell-derived factor-1 is a chemokine that plays a major role during embryogenesis. Since stromal cell-derived factor-1 and its unique receptor CXCR4 are involved in the differentiation of progenitor cells, we studied the expression of this ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42b2a06f98a7eaba6ff5ec1467b0357
https://pubmed.ncbi.nlm.nih.gov/15579440

Species differences in the localisation of gamma-glutamyl transpeptidase immunopositive cells at the blood-brain interface

Autor: H F, Zhang, W Y, Ong, S K, Leong, Y, Laperche

Publikováno v: Journal fur Hirnforschung. 38(3)

The expression of gamma-glutamyl transpeptidase (GGT) has been associated with the emergence of a functional blood-brain barrier. We have undertaken a precise localisation of this enzyme in the cerebral cortical vessels of different species, by immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b7c35d98b8196e747e5eebf3658a018
https://pubmed.ncbi.nlm.nih.gov/9350503