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F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity

Autor: Erin Currie, Isabelle Vandenberghe, Y. Guminski, Nicolas Guilbaud, V. Brel, Anna Kruczynski, A. Pillon, Bruno Gomes, Jean Philippe Annereau, Dominique Bonnet, Laurent Créancier, C. Bailly, Emmanuel Fournier

Publikováno v: Leukemia. 27(11)

Chemotherapy remains mainly used for the treatment of acute myeloid leukemia (AML). However, in the past 3 decades limited progress has been achieved in improving the long-term disease-free survival. Therefore the development of more effective drugs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fd9e5625ea060989882b8a911392f2
https://pubmed.ncbi.nlm.nih.gov/23568148

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ChemInform Abstract: Use of Chiral Glycerol 2,3-Carbonate in the Synthesis of 3-Aryl-2-oxazolidinones

Autor: Y. Guminski, A. Nedelec, Pascal George, Ph. Burnier, J. J. Koenig, S. Jegham, F. Puech

Publikováno v: ChemInform. 29

Substituted chiral 3-aryl-2-oxazolidinones were readily prepared via regiospecific opening of cyclic carbonates with N -arylcarbamates and subsequent cyclization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8249f3b99982eaf9be87018cb853685
https://doi.org/10.1002/chin.199836172

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A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment

Autor: J.-M. Barret, C. Bailly, Jean Philippe Annereau, Y. Guminski, Stéphane Vispé, Nicolas Guilbaud, M. Broussas, V. Brel, Charles Dumontet, S. Bréand, T. Imbert

Publikováno v: Leukemia research. 34(10)

The polyamine transport system (PTS), hyperactive in cancer cells, can constitute a gate to deliver F14512, a novel spermine epipodophyllotoxin conjugate recently selected for clinical development in AML phase I. We investigated in vitro the high ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92ebcf54b50fd26e321b5d3916d301a
https://pubmed.ncbi.nlm.nih.gov/20096930

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Requirements for P-glycoprotein recognition based on structure-activity relationships in the podophyllotoxin series

Autor: C, Etievant, P, Schambel, Y, Guminski, J M, Barret, T, Imbert, B T, Hill

Publikováno v: Anti-cancer drug design. 13(4)

Podophyllotoxin and epipodophyllotoxin react with tubulin at the same binding site as colchicine, but in contrast to colchicine, do not appear to exert their cytotoxicities by mechanisms dependent on P-glycoprotein (Pgp) expression. To investigate st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88204e5be882a84bbac597f26732dce6
https://pubmed.ncbi.nlm.nih.gov/9627671

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A functional procedure using fresh samples to select patients with acute myeloid leukemia prior to treatment with the novel targeted cytotoxic agent F14512

Autor: C. Bailly, T. Imbert, Nicolas Guilbaud, Jean Philippe Annereau, V. Brel, Jean-Marc Barret, Charles Dumontet, Y. Guminski, F. Breillout

Publikováno v: Journal of Clinical Oncology. 27:11087-11087

11087 Background: The Polyamine Transport System (PTS) is an energy-dependent machinery generally hyper-active in cancer cells with a high demand for polyamines. This system can be viewed as a suitable molecular gate to deliver selectively polyamine-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78e0982c5c5489a051b714892e8b4e14
https://doi.org/10.1200/jco.2009.27.15_suppl.11087

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[(125I)iodo-zacopride: new ligand for the study by autoradiography of central 5-HT3 receptors]

Autor: T, Koscielniak, M, Ponchant, A M, Laporte, Y, Guminski, D, Verge, M, Hamon, H, Gozlan

Publikováno v: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 311(6)

This paper describes the synthesis and the pharmacological characteristics of the first radioiodinated ligand of central 5-HT3 receptors: [125I]iodo-zacopride. Specific sites having a high affinity (Kd = 4.3 nM) for [125I]iodo-zacopride have been fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67534d228d1f330399f2c08b91a46b02
https://pubmed.ncbi.nlm.nih.gov/2121314

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Use of chiral glycerol 2,3-carbonate in the synthesis of 3-aryl-2-oxazolidinones

Autor: A. Nedelec, Ph. Burnier, Y. Guminski, J. J. Koenig, S. Jegham, Pascal George, F. Puech

Publikováno v: Tetrahedron Letters. 39:4453-4454

Substituted chiral 3-aryl-2-oxazolidinones were readily prepared via regiospecific opening of cyclic carbonates with N -arylcarbamates and subsequent cyclization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a3f583ab4a0ac8a4fdfd6e064fbf420
https://doi.org/10.1016/s0040-4039(98)00814-4

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