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Akademický článek
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Akademický článek
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Autor:
Gayle K. Lamppa, Ilya Y. Gluzman, Michael Klemba, Marisa Ponpuak, Daniel E. Goldberg, Mehea Park
Publikováno v:
Molecular Microbiology. 63:314-334
Falcilysin (FLN) is a zinc metalloprotease thought to degrade globin peptides in the acidic vacuole of the human malaria parasite Plasmodium falciparum. The enzyme has been found to have acidic or neutral pH optima on different peptides and to have a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742c328905e36821ded50f2de06706b1
https://doi.org/10.1111/j.1365-2958.2006.05443.x
https://doi.org/10.1111/j.1365-2958.2006.05443.x
Autor:
Daniel E. Goldberg, Ilya Y. Gluzman, Natalia S. Akopyants, Anna Oksman, Choukri Ben Mamoun, Rosalie Truong
Publikováno v:
Molecular and Biochemical Parasitology. 103:117-121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a990d3c4e25986cb18b697c8eade45d5
https://doi.org/10.1016/s0166-6851(99)00116-4
https://doi.org/10.1016/s0166-6851(99)00116-4
Publikováno v:
Proceedings of the National Academy of Sciences. 96:8716-8720
Genomic information is rapidly accumulating for the human malaria pathogen, Plasmodium falciparum. Our ability to perform genetic manipulations to understand Plasmodium gene function is limited. Dihydrofolate reductase is the only selectable marker p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eda56b19c659ccdd284899b9a4243cc
https://doi.org/10.1073/pnas.96.15.8716
https://doi.org/10.1073/pnas.96.15.8716
Autor:
Anna Oksman, Daniel E. Goldberg, Roland E. Dolle, Theodore O. Johnson, Daniel Chelsky, Marc Orlowski, Joan Guo, Carolyn DiIanni Carroll, Ilya Y. Gluzman, Tao Guo, Zhen-Min He, Cullen L. Cavallaro, Hitesh K. Patel, James A. Connelly
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2315-2320
An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease required for hemoglobin metabolism in the malaria parasite, led to the identification of pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd938f8a4ac0e0a6defa4e6293b3b48a
https://doi.org/10.1016/s0960-894x(98)00419-3
https://doi.org/10.1016/s0960-894x(98)00419-3
Autor:
Thomas E. Wellems, Anna Oksman, David Piwnica-Worms, Ilya Y. Gluzman, Daniel E. Goldberg, Vivek Sharma
Publikováno v:
Journal of Biological Chemistry. 272:6567-6572
The malaria organism Plasmodium falciparum detoxifies heme released during degradation of host erythrocyte hemoglobin by sequestering it within the parasite digestive vacuole as a polymer called hemozoin. Antimalarial agents such as chloroquine appea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4204932139f8c9e7d4ca3a7883bea0e4
https://doi.org/10.1074/jbc.272.10.6567
https://doi.org/10.1074/jbc.272.10.6567
Publikováno v:
Molecular and Biochemical Parasitology. 83:189-200
In Plasmodium falciparum, a cysteine protease known as falcipain has been implicated in the essential metabolic process of hemoglobin degradation. Parallel lines of investigation, using native or recombinant enzyme, have led to differing conclusions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ede45845f6894f4902546a1004fd7f
https://doi.org/10.1016/s0166-6851(96)02772-7
https://doi.org/10.1016/s0166-6851(96)02772-7
Publikováno v:
Proceedings of the National Academy of Sciences. 93:11865-11870
Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established. We incubate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bb016009c5ab37702dff2d9e55f413
https://doi.org/10.1073/pnas.93.21.11865
https://doi.org/10.1073/pnas.93.21.11865
Autor:
Talapady N. Bhat, Kathryn E. Luker, P Maier, A. Y. Lee, P.J. Collins, Raul E. Cachau, John W. Erickson, Ilya Y. Gluzman, Abelardo M. Silva, Daniel E. Goldberg, Susan E. Francis, Anna Oksman, S V Gulnik, Jack R. Collins
Publikováno v:
Proceedings of the National Academy of Sciences. 93:10034-10039
Plasmodium falciparum is the major causative agent of malaria, a disease of worldwide importance. Resistance to current drugs such as chloroquine and mefloquine is spreading at an alarming rate, and our antimalarial armamentarium is almost depleted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e84d62f204be49b48728bbe51a83bd6
https://doi.org/10.1073/pnas.93.19.10034
https://doi.org/10.1073/pnas.93.19.10034