Výsledky vyhledávání

TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells

Autor: Y Gazitt

Publikováno v: Leukemia. 13:1817-1824

TRAIL, the ligand for the newly discovered DR-4 and DR-5 receptor, is a member of the TNF family of death signal transduction proteins with a mechanism of cell death similar to that of Fas and Fas ligand (Fas-L) system. We provide first time evidence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf100af9081fc63f3a5dc3c05e67164
https://doi.org/10.1038/sj.leu.2401501

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A safe procedure for transporting bone-marrow for purging in a central laboratory

Autor: Y, Gazitt, A, Cantor, S, Koza, J, Grahampole

Publikováno v: Oncology reports. 1(1)

A central facility for ex vivo removal of neuroblastoma cells from bone marrow, to be used for autologous reinfusion after myeloablative treatment, was established and a study was designed to compare the survival time and the rate of bone marrow engr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d686212878b348652aadba6bde2feb4
https://pubmed.ncbi.nlm.nih.gov/21607346

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Regulation of cell-growth and apoptosis in synchronized agf cells - involvement of oncogenes and cell-cycle regulatory proteins

Autor: Mf Lavia, Y Gazitt, Gw Erdos

Publikováno v: International journal of oncology. 3(3)

Cell synchrony was induced in AGF cells by blocking of the cell cycle at GI-S boundary with high concentrations (2 mM) of thymidine for 11 h. Prolonged arrest of cells in GI-S (15 h-20 h) induced progressive and time dependent apoptosis. Early morpho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67b1f70967111cf6240e6818e0cc6d5
https://pubmed.ncbi.nlm.nih.gov/21573390

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Aromatic retinoid Acid-derivatives are potent inducers of differentiation of neuroblastoma-cells - structure-function relationship and the involvement of the nuclear retinoic Acid receptors

Autor: M Rosenberger, Y Gazitt, Da Lucas, Jf Grippo, Rj Prankerd

Publikováno v: International journal of oncology. 5(2)

Twenty-two derivatives of retinoic acid (RA) were tested for their potency to induce in vitro morphological differentiation of SK-N-SH neuroblastoma cell line at concentration range of 0.1 nM to 10 muM. The results indicate that three derivatives Ro-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbc84c8d31718081e20e674be3b9051
https://pubmed.ncbi.nlm.nih.gov/21559582

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Differential expression and subcellular-localization of protein-kinase-C, alpha, gamma, delta, xi and zeta isoforms in agf T-cells - modification during pma-induced differentiation

Autor: Y Gazitt, Gw Erdos, Hava Avraham

Publikováno v: International journal of oncology. 5(2)

The steady-state level and translocation of the protein kinase C (PKC) isozymes during the early stages of phorbol 12-myristate 13-acetate (PMA)-induced differentiation, was followed in AGF cells by Western blot analysis of various cell fractions, im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e911a0d3c2481570ad8a5ced0fbc75
https://pubmed.ncbi.nlm.nih.gov/21559581

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A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate

Autor: Y, Gazitt, S V, Reddy, O, Alcantara, J, Yang, D H, Boldt

Publikováno v: Journal of cellular physiology. 187(1)

To investigate the role of iron in hematopoiesis, we studied effects of iron deprivation on PMA-induced monocyte/macrophage differentiation in HL-60 cells. Iron deprivation induced by desferrioxamine (DF) blocked PMA-induced differentiation and induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03b956b07172c0b2565f29d129bfa317
https://pubmed.ncbi.nlm.nih.gov/11241357

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Collection, tumor contamination, and engraftment kinetics of highly purified hematopoietic progenitor cells to support high dose therapy in multiple myeloma

Autor: G, Tricot, Y, Gazitt, T, Leemhuis, S, Jagannath, K R, Desikan, D, Siegel, A, Fassas, S, Tindle, J, Nelson, C, Juttner, A, Tsukamoto, J, Hallagan, K, Atkinson, C, Reading, R, Hoffman, B, Barlogie

Publikováno v: Blood. 91(12)

Unfractionated peripheral blood stem cell (PBSC) grafts contain measurable quantities of myeloma cells and are therefore a potential source of relapse posttransplantation. In contrast, fluorescence-activated cell sorting (FACS)-sorted CD34+ Thy1+ Lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43382ee83e961a47aba8345387549dd4
https://pubmed.ncbi.nlm.nih.gov/9616143

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Fas (APO-1/CD95)-mediated apoptosis is independent of bcl-2: a study with cell lines overexpressing bcl-2 and with bcl-2 transfected cell lines

Autor: Y, Gazitt, W X, Hu

Publikováno v: International journal of oncology. 12(1)

Eight myeloma cell lines with variable expression of bcl-2 were screened for the expression of the FAS antigen and for sensitivity to anti-FAS-induced apoptosis. Anti-FAS-induced apoptosis correlated positively (R = 0.89) with the level of expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::987acee5136faf920fdf37cd754dbc60
https://pubmed.ncbi.nlm.nih.gov/9454907

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