Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Y, Elisseyeff"'
Autor:
Güray Saydam, M Aracil, Jose Jimeno, Joseph R. Bertino, L D Lewis, Prasunkumar J. Mishra, Debabrata Banerjee, Lata G. Menon, Rita Humeniuk, Y Elisseyeff, G S A Longo-Sorbello
Publikováno v:
Leukemia. 21:2399-2405
Aplidin (plitidepsin) is a novel marine-derived antitumor agent presently undergoing phase II clinical trials in hematological malignancies and solid tumors. Lack of bone marrow toxicity has encouraged further development of this drug for treatment o
Autor:
Richard J. O'Reilly, A Kheradpour, Dieter Dennig, Y Elisseyeff, Erdem Goker, Joseph R. Bertino, Catherine Jagiello, João F. Lacerda
Publikováno v:
Blood. 85:2675-2679
Impaired transport of methotrexate (MTX) is a common resistance mechanism of tumor cells to this drug. Trimetrexate (TMTX), a second-generation folate antagonist, is still active against MTX-transport-resistant cells because it enters cells by passiv
Autor:
William P. Tong, Tanya M. Trippett, Y Elisseyeff, K M VanSyckle, Paul A. Meyers, Cuiwen Tan, Erdem Goker, N Wollner, A Kheradpour, L Guarino
Publikováno v:
Journal of Clinical Oncology. 12:1955-1962
PURPOSE Based on in vitro studies that have shown synergistic effects of sequential administration of methotrexate (MTX) and thioguanine (6-TG), we conducted a pharmacologically guided trial of sequential MTX and 6-TG to determine the following: (1)
Autor:
S Schlemmer, Erdem Goker, Y Elisseyeff, Ellin Berman, Andre Rosowsky, Peter G. Steinherz, Tanya M. Trippett, M Wachter, Cuiwen Tan, JE Wright
Publikováno v:
Blood. 80:1158-1162
Although the mechanisms of resistance to methotrexate (MTX) are known in experimental tumors made resistant to this drug, little information is available regarding acquired resistance to MTX in patients. A competitive displacement assay using the flu
Autor:
W W, Li, N, Takahashi, S, Jhanwar, C, Cordon-Cardo, Y, Elisseyeff, J, Jimeno, G, Faircloth, J R, Bertino
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(9)
The cytotoxic effects of ecteinascidin-743(ET-743), a novel marine natural product, were evaluated and compared with that of clinically used anticancer agents methotrexate, doxorubicin, etoposide, and paclitaxel in eight human soft tissue sarcoma (ST
Autor:
R, Gorlick, E, Goker, T, Trippett, P, Steinherz, Y, Elisseyeff, M, Mazumdar, W F, Flintoff, J R, Bertino
Publikováno v:
Blood. 89(3)
Methotrexate (MTX) transport was examined in 27 patients with untreated acute lymphocytic leukemia (ALL) and 31 patients with relapsed ALL using a previously described fluorescent MTX analog (PT430) displacement assay (Blood 80:1158, 1992). Only 13%
Autor:
Erdem Goker, Madhu Mazumdar, Peter G. Steinherz, Barbara Schnieders, Tanya M. Trippett, Ellin Berman, A Kheradpour, Mark Waltham, Cuiwen Tan, Y Elisseyeff
Publikováno v:
Blood. 86(2)
Although dihydrofolate reductase (DHFR) gene amplification is a common mechanism of resistance to methotrexate (MTX) in tumor cell lines, with the exception of a few case reports, the incidence of this phenomenon as a mechanism of MTX resistance in t
Autor:
J F, Lacerda, E, Göker, A, Kheradpour, D, Dennig, Y, Elisseyeff, C, Jagiello, R J, O'Reilly, J R, Bertino
Publikováno v:
Blood. 85(10)
Impaired transport of methotrexate (MTX) is a common resistance mechanism of tumor cells to this drug. Trimetrexate (TMTX), a second-generation folate antagonist, is still active against MTX-transport-resistant cells because it enters cells by passiv
Publikováno v:
Leukemia. 9(2)
Impaired polyglutamylation of methotrexate (MTX) and thus poor retention is believed to be the basis of intrinsic resistance in blasts from patients with acute myeloid leukemia (AML) to MTX. We studied additional samples from patients with this disea
Autor:
E, Göker, J T, Lin, T, Trippett, Y, Elisseyeff, W P, Tong, D, Niedzwiecki, C, Tan, P, Steinherz, B I, Schweitzer, J R, Bertino
Publikováno v:
Leukemia. 7(7)
We compared blast cells from adult and pediatric patients with untreated acute lymphoblastic leukemia (ALL) (as separated groups of T-lineage cell and B-lineage cell ALL) to determine if methotrexate (MTX) polyglutamate formation in adult patients mi