Výsledky vyhledávání

Amisulpride: from animal pharmacology to therapeutic action

Autor: Bernard Scatton, André Oblin, Ghislaine Perrault, David J. Sanger, Annie Cudennec, Y. Claustre, Hans Schoemaker

Publikováno v: International Clinical Psychopharmacology. 12:S29-S36

Amisulpride is a benzamide derivative with a unique neurochemical and psychopharmacological profile. This compound has selective affinity for human dopamine D3 and D2 receptor subtypes in vitro (binding constant, K approximately 3 nmol/l) and blocks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13f9710a12d03cb990dad441e5771f3
https://doi.org/10.1097/00004850-199705002-00006

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Activation of 5-HT1A receptors inhibits carbachol-stimulated inositol 1,4,5-trisphosphate mass accumulation in the rodent hippocampus

Autor: J. Benavides, Y. Claustre, C. Minisclou

Publikováno v: Neurochemical Research. 20:977-983

We have previously demonstrated that 5-HT1A receptor agonists partially prevent the stimulation by carbachol of [3H]-phosphoinositide hydrolysis in immature rat hippocampal slices. This negative modulation has been investigated further by measuring,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0936a9987d1cbd785c13ed893e2e39b
https://doi.org/10.1007/bf00995549

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5-HTIC receptors mediate phosphoinositide turnover activation in the immature rat hippocampus

Autor: Y. Claustre, Bernard Scatton, Jesus Benavides, B. Eudeline

Publikováno v: European Journal of Pharmacology: Molecular Pharmacology. 225:37-41

The activation of phosphoinositide turnover in rat cerebral cortex and choroid plexus is triggered by the stimulation of 5-HT2 and 5-HTIC receptors, respectively. To characterize the 5-HT receptor subtype mediating the activation of phosphoinositide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::294e4bc74a1c4ebf7f38ade3023c5777
https://doi.org/10.1016/0922-4106(92)90036-u

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Potential Mechanisms Involved in the Negative Coupling Between Serotonin 5-HT1AReceptors and Carbachol-Stimulated Phosphoinositide Turnover in the Rat Hippocampus

Autor: Y. Claustre, Jesus Benavides, Bernard Scatton

Publikováno v: Journal of Neurochemistry. 56:1276-1285

Serotonin 5-HT1A receptors have been reported to be negatively coupled to muscarinic receptor-stimulated phosphoinositide turnover in the rat hippocampus. In the present study, we have investigated further the pharmacological specificity of this nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08dca271d24e1344868f70b53c9201d6
https://doi.org/10.1111/j.1471-4159.1991.tb11422.x

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Effects of the beta3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile

Autor: Liliane Rouquier, S. Busch, M. Tocci, Y. Claustre, M. Didier, Patrick Avenet, C. Desvignes, Yangde Chen, V. Palejwala, P. Yamdagni, Régis Steinberg, M. Leonetti, Vincent Santucci, N. Aubin, G Le Fur, Bernard Scatton, P.E. Keane, F. Oury-Donat, I. Bougault

Publikováno v: Neuroscience. 156(2)

SR58611A is a selective beta(3)-adrenoceptor (Adrb3) agonist which has demonstrated antidepressant and anxiolytic properties in rodents. The present study confirmed the detection of Adrb3 mRNA transcript in rodent brain sub-regions and evaluated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd96a4ba9617fe2ec4f57de2f3727df
https://pubmed.ncbi.nlm.nih.gov/18691638

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Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat

Autor: I. Bougault, F. Oury-Donat, M. Leonetti, Y. Claustre, N. Allouard, Régis Steinberg, L. Rouquier, N. Aubin, C. Desvignes, J. Montégut

Publikováno v: Neuroscience. 141(3)

Arginine vasopressin and corticotropin-releasing factor are two neuroactive peptides that regulate hypothalamic–pituitary-axis and associated stress response. While the potential antidepressant and anxiolytic profiles of corticotropin-releasing fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bbcd0db2278cba42a548c6a4766976c
https://pubmed.ncbi.nlm.nih.gov/16781820

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SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair

Autor: Benoit Marabout, Y. Claustre, Gilles Poughon, Jacqueline Fournier, Genevieve Bourliaud, Jesus Benavides, Pascal George, Jean-Pierre Robert, Philippe Soubrie, Franck Marguet, Michael Schumacher, Jean-Pierre Nowicki, Bernard Scatton, Emmanuel Brault, Mireille Sevrin, Philippe Liere, Badia Ferzaz

Publikováno v: The Journal of pharmacology and experimental therapeutics. 301(3)

In the present study, we have investigated the potential neuroprotective effects of a novel peripheral benzodiazepine binding site (PBR) ligand, 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575), i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfeaec394c48e8e16a448a6c9e390483
https://pubmed.ncbi.nlm.nih.gov/12023539

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The preclinical pharmacologic profile of tiapride

Autor: David J. Sanger, Bernard Scatton, H. Schoemaker, Gh. Perrault, Y. Claustre, R Porsolt, Caroline Cohen, A. Oblin, L Rouquier

Publikováno v: European psychiatry : the journal of the Association of European Psychiatrists. 16

SummaryTiapride is a benzamide derivative that has been used successfully in the clinic for a number of years for the treatment of agitation and aggressiveness in elderly patients. Like many substituted benzamides, tiapride specifically blocks dopami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d04b9358c320326d31ae3d335989fd0
https://pubmed.ncbi.nlm.nih.gov/11520476

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Discriminative stimulus effects of drugs acting at GABA(A) receptors: differential profiles and receptor selectivity

Autor: D J, Sanger, G, Griebel, G, Perrault, Y, Claustre, H, Schoemaker

Publikováno v: Pharmacology, biochemistry, and behavior. 64(2)

The GABA(A) receptor complex contains a number of binding sites at which a variety of psychotropic drugs, including benzodiazepines, barbiturates, and some neurosteroids, act to potentiate or inhibit the effect of the transmitter. Many studies have r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f32fd505c21deeb7bf9fea407bb5c94
https://pubmed.ncbi.nlm.nih.gov/10515302

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