Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Xuyuan Gu"'
Autor:
Lamya H. Al-Wahaibi, Anber F. Mohammed, Fatema El-Zahraa S. Abdel Rahman, Mostafa H. Abdelrahman, Xuyuan Gu, Laurent Trembleau, Bahaa G. M. Youssif
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both wild and mutant type EGFR. The antiproliferative effect of the new compounds was studied. 5c
Externí odkaz:
https://doaj.org/article/ad0d6b80431c4610aa5b365ed3465666
Autor:
Ahmed H. Abdelazeem, Hesham A.M. Gomaa, Noura M. Abo Shama, Lamya H. Al-Wahaibi, Fatma A.M. Mohamed, Yaser A. Mostafa, Laurent Trembleau, Mohamed A. Ali, Xuyuan Gu, Mahmoud Shehata, Ahmed Mostafa, Ahmed M. Gouda, Ola F. Abou-Ghadir, Omnia Kutkat, Bahaa G.M. Youssif, Mostafa H. Abdelrahman
Publikováno v:
Bioorganic Chemistry
Graphical abstract
We have discovered a family of synthetic oxazole-based macrocycles to be active against SARS-CoV-2. The synthesis, pharmacological properties, and docking studies of the compounds are reported in this study. The structure of t
We have discovered a family of synthetic oxazole-based macrocycles to be active against SARS-CoV-2. The synthesis, pharmacological properties, and docking studies of the compounds are reported in this study. The structure of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab494026f0223243bfeaba02419ade3
http://europepmc.org/articles/PMC8445767
http://europepmc.org/articles/PMC8445767
Autor:
Xuyuan Gu, Sukeshi J. Mehta, Bryan Grossman, Gary S. Nichol, Victor J. Hruby, Hongchang Qu, Zhihua Liu, Kwang Soo Lee
Publikováno v:
The Journal of Organic Chemistry. 77:1289-1300
Multifunctionalized amino acids, especially amino acids with unsaturation, are important, demanding building blocks in peptide chemistry. Here we present a summary of our most recent study using the thio-Claisen rearrangement for the synthesis of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6a5bb1ddc55fdcee9f271cab683204
https://doi.org/10.1021/jo201753q
https://doi.org/10.1021/jo201753q
Autor:
The PandaX-4T collaboration, Zhicheng Qian, Lin Si, Abdusalam Abdukerim, Zihao Bo, Wei Chen, Xun Chen, Yunhua Chen, Chen Cheng, Yunshan Cheng, Xiangyi Cui, Yingjie Fan, Deqing Fang, Changbo Fu, Mengting Fu, Lisheng Geng, Karl Giboni, Linhui Gu, Xuyuan Guo, Ke Han, Changda He, Jinrong He, Di Huang, Yanlin Huang, Zhou Huang, Ruquan Hou, Xiangdong Ji, Yonglin Ju, Chenxiang Li, Mingchuan Li, Shu Li, Shuaijie Li, Qing Lin, Jianglai Liu, Xiaoying Lu, Lingyin Luo, Wenbo Ma, Yugang Ma, Yajun Mao, Yue Meng, Xuyang Ning, Ningchun Qi, Xiangxiang Ren, Nasir Shaheed, Changsong Shang, Guofang Shen, Wenliang Sun, Andi Tan, Yi Tao, Anqing Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Zhou Wang, Mengmeng Wu, Weihao Wu, Jingkai Xia, Mengjiao Xiao, Xiang Xiao, Pengwei Xie, Binbin Yan, Xiyu Yan, Jijun Yang, Yong Yang, Chunxu Yu, Jumin Yuan, Ying Yuan, Dan Zhang, Minzhen Zhang, Peng Zhang, Tao Zhang, Li Zhao, Qibin Zheng, Jifang Zhou, Ning Zhou, Xiaopeng Zhou, Yong Zhou
Publikováno v:
Journal of High Energy Physics, Vol 2022, Iss 6, Pp 1-20 (2022)
Abstract PandaX-4T is a ton-scale dark matter direct detection experiment using a dual-phase TPC technique at the China Jinping Underground Laboratory. Various ultra-low background technologies have been developed and applied to material screening fo
Externí odkaz:
https://doaj.org/article/931ea45fbbc34eb4b75ba4f719d9d30c
Publikováno v:
Organic Letters. 10:4105-4108
A novel synthesis of optically active anti-beta-substituted gamma,delta-unsaturated amino acids via a thio-Claisen rearrangement has been achieved. A 2,5-diphenylpyrrolidine was used as a C2-symmetric chiral auxiliary to control the stereochemistry,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9897dd22a06411e26c78c81f91345a2e
https://doi.org/10.1021/ol801657q
https://doi.org/10.1021/ol801657q
Publikováno v:
Peptides. 29:104-111
Melanocortin receptors are considered promising candidates for the treatment of behavioral and metabolic disorders ranging from obesity to anorexia and cachexia. These experiments examined the response of mice to peripheral injections of two compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad09bd21c777679bb013679f28ab3e94
https://doi.org/10.1016/j.peptides.2007.10.014
https://doi.org/10.1016/j.peptides.2007.10.014
Autor:
John M. Ndungu, Hank Wooden, Xuyuan Gu, Wei Qiu, Michael D. Carducci, Victor J. Hruby, Jinfa Ying
Publikováno v:
Tetrahedron. 60:8233-8243
The enantiomeric syntheses of ω-unsaturated amino acids and β-substituted ω-unsaturated amino acids were accomplished by using Gly-Ni-2[N-(N′-benzylprolyl)amino]benzophenone (BPB) as a chiral auxiliary. The synthesis provides excellent yields an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::690c314d43de41e2f87b43292dccc278
https://doi.org/10.1016/j.tet.2004.06.087
https://doi.org/10.1016/j.tet.2004.06.087
Autor:
Frank Porreca, Xuyuan Gu, Edita Navratilova, Peg Davis, Henry I. Yamamura, Gannon Stahl, Richard S. Agnes, Victor J. Hruby, Jinfa Ying
Publikováno v:
Organic Letters. 6:3285-3288
[structure: see text] External bicyclic beta-turn dipeptide mimetics provide an excellent design approach that can offer a rich chiral ensemble of structures with different backbone conformations. We report herein a novel design of a convergent combi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eaa92b2027863343c5149162f277278
https://doi.org/10.1021/ol0488183
https://doi.org/10.1021/ol0488183
Autor:
John M. Ndungu, James P. Cain, Xuyuan Gu, Dustin E. Gross, Victor J. Hruby, Michael D. Carducci
Publikováno v:
Tetrahedron Letters. 45:4139-4142
The cholecystokinin C-terminal octapeptide analogue H-Asp-Tyr-D-Phe-Gly-Trp-(N-Me)-Nle-Asp-Phe-NH2 (SNF 9007) is a potent and selective ligand for both the CCK-B and δ-opioid receptors. To constrain the peptide into the biologically active conformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe17cdf7a3c8080294dddb46e9dd132
https://doi.org/10.1016/j.tetlet.2004.03.146
https://doi.org/10.1016/j.tetlet.2004.03.146
Publikováno v:
Tetrahedron Letters. 43:6669-6672
A novel strategy toward the syntheses of [6,5]-bicyclic β-turn dipeptides has been developed starting from δ,e-unsaturated amino acids. This is the first example showing that this scaffold can be synthesized from a terminal alkene using a trifluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2249401cba97b37427f7fb4af26f61d3
https://doi.org/10.1016/s0040-4039(02)01338-2
https://doi.org/10.1016/s0040-4039(02)01338-2