Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Xuyu Tan"'
Autor:
Genwei Zhang, Joseph S. Brown, Anthony J. Quartararo, Chengxi Li, Xuyu Tan, Stephanie Hanna, Sarah Antilla, Amanda E. Cowfer, Andrei Loas, Bradley L. Pentelute
Publikováno v:
Communications Chemistry, Vol 5, Iss 1, Pp 1-10 (2022)
Angiotensin converting enzyme 2 (ACE2) has been identified as a cardiovascular disease biomarker and the primary receptor utilized by SARS-CoV-2, but developing serum-stable, selective and high-affinity binders for this target is challenging. Here, t
Externí odkaz:
https://doaj.org/article/148c1454126b4e02903048591db85c6f
Publikováno v:
Macromolecules
Herein, we demonstrate that macromonomers consisting of organics-soluble, chemically protected oligonucleotides (protDNA) and poly(ethylene glycol) (PEG) chains can be converted into bottlebrush polymers of distinct architectures via ring-opening met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf2722c9d9ac0fa0c684ff07ca5b868
https://pubmed.ncbi.nlm.nih.gov/36187461
https://pubmed.ncbi.nlm.nih.gov/36187461
Autor:
Peiru Chen, Mengqi Ren, Yuyan Wang, Jiansong Cai, Yang Fang, Dali Wang, Hao Lu, Xueyan Cao, Fei Jia, Ke Zhang, Xueguang Lu, Lei Zhang, Xuyu Tan, Yehui Sun
Publikováno v:
ACS Appl Mater Interfaces
Despite potency against a variety of cancers in preclinical systems, melittin (MEL), a major peptide in bee venom, exhibits non-specific toxicity, severe hemolytic activity, and poor pharmacological properties. Therefore, its advancement in the clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ba3af2c222d04f4a6bc8525f4b89a6
https://doi.org/10.1021/acsami.1c14285
https://doi.org/10.1021/acsami.1c14285
Autor:
Yuyan Wang, Hao Lu, Jiansong Cai, Xi Kang, Yang Fang, Jennifer Union, Lei Zhang, Dali Wang, Xuyu Tan, Fei Jia, Ke Zhang, Peiru Chen, Xueguang Lu, Yehui Sun, Mengqi Ren
Publikováno v:
J Am Chem Soc
Oligonucleotide-based materials such as spherical nucleic acid (SNA) have been reported to exhibit improved penetration through the epidermis and the dermis of the skin upon topical application. Herein, we report a self-assembled, skin-depigmenting S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6455becac239dd3990b31fc64fb6096b
https://doi.org/10.1021/jacs.0c12044
https://doi.org/10.1021/jacs.0c12044
Publikováno v:
J Control Release
Nucleic acids have not been widely considered as an optimal material for drug delivery. Indeed, unmodified nucleic acids are enzymatically unstable, too hydrophilic for cell uptake and payload encapsulation, and may cause unintended biological respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524a6f6368d248210f7c90379fbecb37
https://doi.org/10.1016/j.jconrel.2020.03.040
https://doi.org/10.1016/j.jconrel.2020.03.040
Autor:
Lei Zhang, Mengqi Ren, Jiansong Cai, Peiru Chen, Fei Jia, Xi Kang, Ke Zhang, Yang Fang, Xuyu Tan, Andrew Miller, Hao Lu, Yuyan Wang, Dali Wang
Publikováno v:
ACS Appl Mater Interfaces
Herein, we report a novel strategy to enhance the antisense activity and the pharmacokinetics of therapeutic oligonucleotides. Through the DNA hybridization chain reaction, DNA hairpins modified with poly(ethylene glycol) (PEG) form a bottlebrush arc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c8061ad1934f56e183572dbd8d16d7
https://pubmed.ncbi.nlm.nih.gov/32936615
https://pubmed.ncbi.nlm.nih.gov/32936615
Publikováno v:
Journal of materials chemistry. B. 8(31)
Self-immolative polymers (SIPs) have been under development for over a decade, and efforts for their application followed shortly after their inception. One main area of application of SIPs is biomedicine, where they are used to construct devices and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8af03c4352c7ea82478ea4dd29f219
https://pubmed.ncbi.nlm.nih.gov/32597455
https://pubmed.ncbi.nlm.nih.gov/32597455
Autor:
Hui Li, Zehong Cheng, Bohan Zhang, Xueguang Lu, Dagoberto O. Silva, Xuyu Tan, Fei Jia, Ke Zhang, Chad A. Mirkin, Yang Li, Henri Stephan Schrekker, Yue Xiao
Publikováno v:
Spherical Nucleic Acids ISBN: 9781003056713
Spherical Nucleic Acids ISBN: 9780429200151
Spherical Nucleic Acids ISBN: 9780429200151
Significance Spherical nucleic acids (SNAs) made thus far are inherently polydisperse due to variations in surface nucleic acid density, particle size, or both. In this article, we describe the synthesis and characterization of two types of molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bca187cf4c9f4cbb05381b44597a8bc
https://doi.org/10.1201/9781003056713-20
https://doi.org/10.1201/9781003056713-20
Autor:
Andrei Loas, Alexander R. Loftis, Sebastian Pomplun, Genwei Zhang, Bradley L. Pentelute, Xuyu Tan
Coronavirus disease 19 (COVID-19) is an emerging global health crisis. With over 7 million confirmed cases to date, this pandemic continues to expand, spurring research to discover vaccines and therapies. SARS-CoV-2 is the novel coronavirus responsib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86fdb51d806b1994d9dba92381a5c1d
https://doi.org/10.1101/2020.03.19.999318
https://doi.org/10.1101/2020.03.19.999318