Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Xuyu Qian"'
Autor:
Kelly Smith, Maya Talukdar, Grace Hwang, Rosie Bunton-Stasyshyn, Xuyu Qian, Jack Marciano, Janet Song, Youngshin Lim
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Sonic hedgehog signaling regulates processes of embryonic development across multiple tissues, yet factors regulating context-specific Shh signaling remain poorly understood. Exome sequencing of families with polymicrogyria (disordered cortical foldi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9224f0517b939d2486d2e621db1ad89c
https://doi.org/10.1073/pnas.2209964120
https://doi.org/10.1073/pnas.2209964120
Autor:
Dennis Jgamadze, James T. Lim, Zhijian Zhang, Paul M. Harary, James Germi, Kobina Mensah-Brown, Christopher D. Adam, Ehsan Mirzakhalili, Shikha Singh, Jiahe Ben Gu, Rachel Blue, Mehek Dedhia, Marissa Fu, Fadi Jacob, Xuyu Qian, Kimberly Gagnon, Matthew Sergison, Oceane Fruchet, Imon Rahaman, Huadong Wang, Fuqiang Xu, Rui Xiao, Diego Contreras, John A. Wolf, Hongjun Song, Guo-li Ming, Han-Chiao Isaac Chen
Publikováno v:
Cell Stem Cell. 30:137-152.e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b5450fd8af93745b0d2511990d9f67c
https://doi.org/10.1016/j.stem.2023.01.004
https://doi.org/10.1016/j.stem.2023.01.004
Autor:
Yichen Cheng, Angelica Medina, Zhenlan Yao, Mausumi Basu, Janhavi P. Natekar, Jianshe Lang, Egan Sanchez, Mezindia B. Nkembo, Chongchong Xu, Xuyu Qian, Phuong T.T. Nguyen, Zhexing Wen, Hongjun Song, Guo-Li Ming, Mukesh Kumar, Margo A. Brinton, Melody M.H. Li, Hengli Tang
Publikováno v:
Cell Reports. 39:110885
Physiological blood-tissue barriers play a critical role in separating the circulation from immune-privileged sites and denying access to blood-borne viruses. The mechanism of virus restriction by these barriers is poorly understood. We utilize induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f455b08ba9bbed56bb08de9a412424c
https://doi.org/10.1016/j.celrep.2022.110885
https://doi.org/10.1016/j.celrep.2022.110885
Autor:
Connor J. Kenny, Ellen M DeGennaro, Andrew B. Stergachis, Lariza M. Rento, Marc Beaudin, M. Aurel Nagy, Peter P. Wang, Kelly M. Girskis, Taehwan Shin, Michael E. Greenberg, Elizabeth A. Pollina, Peter V. Kharchenko, Ryan N. Doan, Julia L. Scotellaro, Xuyu Qian, Nenad Sestan, Jean Fan, Brian M. Debo, Janet H.T. Song, Dilenny M. Gonzalez, André M. M. Sousa, Rebecca C. Yeh, Christopher A. Walsh, Matthew B. Johnson, Gabrielle M. Sejourne
Publikováno v:
Neuron. 109(20)
Summary Human accelerated regions (HARs) are the fastest-evolving regions of the human genome, and many are hypothesized to function as regulatory elements that drive human-specific gene regulatory programs. We interrogate the in vitro enhancer activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec719659af0fbbd154432819136f29cc
https://pubmed.ncbi.nlm.nih.gov/34672980
https://pubmed.ncbi.nlm.nih.gov/34672980
Publikováno v:
Development. 144:952-957
Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e960ff362a67697a1296c914531d3eca
https://doi.org/10.1242/dev.140707
https://doi.org/10.1242/dev.140707
Publikováno v:
Development. 146
Brain organoids are self-assembled three-dimensional aggregates generated from pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic human brain. As such, they have emerged as novel model systems that can be used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80992a1068e14ed1bb67aab96e50eb89
https://doi.org/10.1242/dev.166074
https://doi.org/10.1242/dev.166074
Autor:
Hengli Tang, Emily M. Lee, Jaehoon Shin, Ruth Didier, Guo Li Ming, Bing Yao, Yujing Li, Xuyu Qian, Hongjun Song, Zhexing Wen, Peng Jin, Christy Hammack, Sarah C. Ogden, Feiran Zhang, Kimberly M. Christian
Publikováno v:
Cell Stem Cell. 18:587-590
SUMMARY The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492f9e83de6be588759ffdde51269bbf
https://doi.org/10.1016/j.stem.2016.02.016
https://doi.org/10.1016/j.stem.2016.02.016
Autor:
H. Isaac Chen, Hao Wu, Lisa A. Briand, Zhexing Wen, Ahmet Hoke, Guo Li Ming, Kenong Su, Shiying Li, John A. Wolf, Ethan M. Goldberg, Lu Lu, Sooyoung Huh, R. Christopher Pierce, Phuong T.T. Nguyen, Hongjun Song, Xuyu Qian, Andre U. Deutschmann, Yijing Su, Sarshan R. Pather, Christopher D. Adam, Sarah E. Swinford-Jackson, Fadi Jacob, Xiaosong Gu
Publikováno v:
Cell Stem Cell
Human brain organoids provide unique platforms for modeling development and diseases by recapitulating the architecture of the embryonic brain. However, current organoid methods are limited by interior hypoxia and cell death due to insufficient surfa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ad40b4596623a647d4a6b491bf297f
https://doi.org/10.1016/j.stem.2020.02.002
https://doi.org/10.1016/j.stem.2020.02.002
Autor:
Dmitriy Petrov, Di-ao Liu, H. Isaac Chen, Deeksha Saxena, Phuong T.T. Nguyen, Xuyu Qian, MacLean Nasrallah, Radhika Thokala, Samuel Zheng Hao Wong, Timothy H. Lucas, Jay F. Dorsey, Fadi Jacob, Donald M. O'Rourke, Steven Brem, Ryan D Salinas, Kimberly M. Christian, Guo Li Ming, Hongjun Song, Jordan G. Schnoll, Daniel Y. Zhang, Stefan Prokop, Saad Sheikh, Zev A. Binder
Publikováno v:
Cell. 180:188-204.e22
Summary Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development of effective therapeutic strategies. Current in vitro models are limited in preserving the cellular and mutational diversity of parental tumors an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af65913a28e1070236db1cc427b286ef
https://doi.org/10.1016/j.cell.2019.11.036
https://doi.org/10.1016/j.cell.2019.11.036
Human brain organoids, 3D self-assembled neural tissues derived from pluripotent stem cells, are important tools for studying human brain development and related disorders. Suspension cultures maintained by spinning bioreactors allow for the growth o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c653046d9d73cb3c14a957c3b3b90876
https://europepmc.org/articles/PMC6241211/
https://europepmc.org/articles/PMC6241211/
