Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Xuyao ZHANG"'
Autor:
Wenjing Xue, Caili Xu, Kaiqi Zhang, Lu Cui, Xiting Huang, Yanyang Nan, Dianwen Ju, Xusheng Chang, Xuyao Zhang
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Claudin18.2 (CLDN18.2) is overexpressed in cancers of the digestive system, rendering it an ideal drug target for antibody-drug conjugates (ADCs). Despite many CLDN18.2-directed ADCs undergoing clinical trials, the inconclusive underlying me
Externí odkaz:
https://doaj.org/article/1c6884e23f074c82bad904974747cf43
Autor:
Caili Xu, Xiting Huang, Qinchao Hu, Wenjing Xue, Kaicheng Zhou, Xingxiu Li, Yanyang Nan, Dianwen Ju, Ziyu Wang, Xuyao Zhang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117550- (2024)
Pancreatic cancer, characterized by a dismal prognosis and limited treatment options, persists as a formidable challenge in oncology. Trophoblast cell surface antigen 2 (TROP2)-directed antibody-drug conjugates have achieved great success in solid tu
Externí odkaz:
https://doaj.org/article/d27020e0913948fc9462fb4fa69449f4
Autor:
Yu Bai, Tao Wu, Jun Lin, Shuwen Xu, Xian Zeng, Xuyao Zhang, Jiajun Fan, Dianwen Ju, Mengyang Li, Yanyang Nan, Xiaozhi Hu, Kaicheng Zhou, An Zhu, Zihan Dou, Zhonglian Cao, Xumeng Zhang, Yuanzhen Zhang, Xuebin Wang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background The main challenge against patients with cancer to derive benefits from immune checkpoint inhibitors targeting PD-1/PD-L1 appears to be the immunosuppressive tumor microenvironment (TME), in which IL-33/ST2 signal fulfills critical functio
Externí odkaz:
https://doaj.org/article/638af0fc590f47d4ba79bf0e0c80b015
Autor:
Yichen Wang, Yanyang Nan, Chunguang Ma, Xiaolin Lu, Qian Wang, Xiting Huang, Wenjing Xue, Jiajun Fan, Dianwen Ju, Dingwei Ye, Xuyao Zhang
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-10 (2024)
Abstract Research and development on Nectin-4 antibody-drug conjugates (ADC) have been greatly accelerated since the approval of enfortumab vedotin to treat uroepithelial cancer. During the course of this study, we identified that autophagy serves as
Externí odkaz:
https://doaj.org/article/77357d89c42e4cefac8fc93cf70a5378
Autor:
Xiaozhi Hu, Yanyang Nan, Yuting Zhang, Jiajun Fan, Hanqi Wang, Yu Bai, Yuanzhen Zhang, Xuyao Zhang, Zeguo Zhu, Zhonglian Cao, Xiaomiao Ye, Tao Wu, Shuwen Xu, Zhengyu Wu, Wei Hu, Dianwen Ju
Publikováno v:
Pharmacological Research, Vol 210, Iss , Pp 107486- (2024)
Atherosclerosis (AS) ultimately cause major adverse cardiovascular events (MACEs). While traditional strategies by lipid-reducing have reduced MACEs, many patients continue to face significant risks. It might attribute to the upregulation of CD47 exp
Externí odkaz:
https://doaj.org/article/637d954985274bcfaf351c2a9e188bf5
Autor:
Peng He, Sijing Huang, Rui Wang, Yunkai Yang, Shangye Yang, Yue Wang, Mengya Qi, Jiyang Li, Xiaofen Liu, Xuyao Zhang, Meiqing Feng
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTNew Delhi metallo-β-lactamase-1 (NDM-1) has rapidly disseminated worldwide, leading to multidrug resistance and worse clinical prognosis. Designing and developing effective NDM-1 inhibitors is a critical and urgent challenge. In this study,
Externí odkaz:
https://doaj.org/article/ab4d2c5fb4c74857a2ec4afc982382b4
Publikováno v:
Biomedicines, Vol 12, Iss 9, p 2152 (2024)
Background: Although immunotherapy has shown potential in cancer treatment, current immunotherapeutics for bladder cancer are limited by a low response rate. Therefore, it is necessary to investigate other suitable immunotherapeutic targets and strat
Externí odkaz:
https://doaj.org/article/8db267586fa24262b4b3f9c641417b78
Autor:
Caili Xu, Min Zhu, Qian Wang, Jiajun Cui, Yuping Huang, Xiting Huang, Jing Huang, Junwei Gai, Guanghui Li, Peng Qiao, Xian Zeng, Dianwen Ju, Yakun Wan, Xuyao Zhang
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Pancreatic cancer is a highly aggressive malignancy with limited treatment options and a poor prognosis. Trophoblast cell surface antigen 2 (TROP2), a cell surface antigen overexpressed in the tumors of more than half of pancreati
Externí odkaz:
https://doaj.org/article/a6f48e10988c48baa5b2ad23aeba0f2d
Publikováno v:
Journal of the American Society for Horticultural Science, Vol 148, Iss 2, Pp 53-63 (2023)
As one of the most important fruit tree crops, apple (Malus ×domestica), is faced with the serious impact of soil salinization. However, the underlying genetic and regulatory network remains elusive. Here, we adopted time-course RNA sequencing to de
Externí odkaz:
https://doaj.org/article/f3fda67b54164c0494c780ca0b85bec7
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/d345b198188c4fc381ef8335a7eafd52