Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Xushan, Wang"'
Autor:
Stacy A. Castner, Linli Zhang, Charles R. Yang, Junliang Hao, Jeffrey W. Cramer, Xushan Wang, Robert F. Bruns, Hugh Marston, Kjell A. Svensson, Graham V. Williams
Publikováno v:
Psychopharmacology. 240:1033-1048
Rationale Dopamine (DA) signaling through the D1 receptor has been shown to be integral to multiple aspects of cognition, including the core process of working memory. The discovery of positive allosteric modulators (PAMs) of the D1 receptor has enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6213ca6a6549d7eb6e405c83245911c
https://doi.org/10.1007/s00213-022-06282-7
https://doi.org/10.1007/s00213-022-06282-7
Autor:
Xushan Wang, Erik J. Hembre, Paul J. Goldsmith, James P. Beck, Kjell A. Svensson, Francis S. Willard, Robert F. Bruns
Publikováno v:
Molecular Pharmacology. 103:176-187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7723d763402ad2f1fa7e81b92f95979a
https://doi.org/10.1124/molpharm.122.000605
https://doi.org/10.1124/molpharm.122.000605
Autor:
Robert F. Bruns, Qi Chen, Paloma Vidal, John Mehnert Schaus, Charles R. Yang, Stephen N. Mitchell, Steven Marc Massey, Nuria Diaz, Xushan Wang, David Andrew Coates, Rebecca A. Wright, Beverly A. Heinz, Kevin Matthew Gardinier, Greg Stephenson, James P. Beck, Rajni M. Bhardwaj, Julie F. Falcone, Bruce A. Dressman, Deanna L Maren, Anette M. Johansson, David Michael Remick, Jeff W. Cramer, Cohen Michael Philip, Brian Morgan Watson, Jeffery Richardson, Kjell Svensson, Xin Zhou, Erik James Hembre, Serge Louis Boulet, Reinhard Matthew Robert, Daniel S. Richards, Junliang Hao, David M. Bender, Guy Carter, Christopher David Beadle, Brian G. Getman, Wolfangel Craig Daniel, Diseroad Benjamin Alan, Jason K. Myers, Joseph H. Krushinski, David Edward Tupper
Publikováno v:
Journal of Medicinal Chemistry. 62:8711-8732
Clinical development of catechol-based orthosteric agonists of the dopamine D1 receptor has thus far been unsuccessful due to multiple challenges. To address these issues, we identified LY3154207 (...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a353395d3c6f7ca6dfa78c95a347dd4
https://doi.org/10.1021/acs.jmedchem.9b01234
https://doi.org/10.1021/acs.jmedchem.9b01234
Publikováno v:
Applied Surface Science. 484:62-71
The traditional methods to introduce multi-functional groups onto the surface of membrane require unpleasant reaction conditions and complex procedures. Motivated by the need of an economical purification method in the downstream processing of therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bd138201b5d834adf747beb1d3ac7b5
https://doi.org/10.1016/j.apsusc.2019.04.106
https://doi.org/10.1016/j.apsusc.2019.04.106
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fd3a986aac486e41e6ea738f1a4465
https://doi.org/10.1021/acs.jmedchem.7b01481
https://doi.org/10.1021/acs.jmedchem.7b01481
Publikováno v:
Applied Surface Science. 428:41-53
A fast and facile protocol is reported aiming at improving the antifouling property and hemocompatibility of poly(vinylidene fluoride) (PVDF) membranes by tethering PEG hydrogel and zwitterion immobilization. The coated PEG hydrogel was first prepare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8455a6c1d8199059c900ace04c753b9d
https://doi.org/10.1016/j.apsusc.2017.09.112
https://doi.org/10.1016/j.apsusc.2017.09.112
Publikováno v:
Applied Surface Science. 419:546-556
Antifouling PVDF membranes were prepared by grafting hyperbranched polyols on the membrane surface via a three-step modification method. The membrane was first prepared by alkaline treatment to introduce alkenyl groups, then chemically immobilizing h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34f14629a955d3dd65fa1211eca184f3
https://doi.org/10.1016/j.apsusc.2017.05.037
https://doi.org/10.1016/j.apsusc.2017.05.037
Autor:
David O. Calligaro, Paul L. Ornstein, Renhua Li, Phillips K, David L. McKinzie, Allen D, Jun-Xu Li, James A. Monn, Bryan G. Johnson, Stephon C. Smith, Jeffrey M. Witkin, Charles H. Mitch, Beverly A. Heinz, Steven Swanson, Gilmour G, Xushan Wang
Publikováno v:
Pharmacology Biochemistry and Behavior. 155:43-55
The novel mGlu2/3 receptor antagonist, LY3020371, has been shown to produce antidepressant-like effects comparable to that of the clinically-effective antidepressant ketamine. In the present study, we investigated whether LY3020371 would be predicted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be5d9f0613b0e20654a6756ac6802a7
https://doi.org/10.1016/j.pbb.2017.03.001
https://doi.org/10.1016/j.pbb.2017.03.001
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546651449b4bbed891b5bffae098620b
https://doi.org/10.1016/j.bmcl.2016.10.067
https://doi.org/10.1016/j.bmcl.2016.10.067