Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Xurui, Jin"'
Autor:
Zhangming Niu, Xianglu Xiao, Wenfan Wu, Qiwei Cai, Yinghui Jiang, Wangzhen Jin, Minhao Wang, Guojian Yang, Lingkang Kong, Xurui Jin, Guang Yang, Hongming Chen
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-15 (2024)
Abstract Accurately predicting ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties early in drug development is essential for selecting compounds with optimal pharmacokinetics and minimal toxicity. Existing ADMET-related
Externí odkaz:
https://doaj.org/article/4e067a8038d445578f77cf5d1cdc40e2
Autor:
Shangzhi Xiong, Gangjiao Zhu, Rahul Malhotra, Xinyue Chen, Enying Gong, Zhan Wang, Jian'An Zhang, Weixia Peng, Shiwei Wang, Xurui Jin, Nicholas Peoples, Truls Østbye, Maoyi Tian, Lijing L Yan
Publikováno v:
PLOS Global Public Health, Vol 4, Iss 8, p e0003549 (2024)
The importance of community-based non-communicable disease (NCD) management has been internationally recognized. However, currently, no instrument is available to evaluate a community's ability to provide NCD management for its residents. This study
Externí odkaz:
https://doaj.org/article/23dfa78b59f245d4841e25a0e2a7ac7f
Autor:
Yinghui Jiang, Shuting Jin, Xurui Jin, Xianglu Xiao, Wenfan Wu, Xiangrong Liu, Qiang Zhang, Xiangxiang Zeng, Guang Yang, Zhangming Niu
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Informative molecular representation is a vital prerequisite in artificial intelligence-driven de novo drug discovery, however, mapping the pharmacophoric information is underexploited by the atom-level based molecular graph representation. Here, the
Externí odkaz:
https://doaj.org/article/aa1a6806e682435c90f75b0b6e2b127c
Autor:
Zhengting He, Qi Guo, Yikai Ling, Chuan Hong, Yuqing Liu, Xurui Jin, Porama Thanaporn, Duan Zhao, Leiting Wang, Liang Liu, Lijing L. Yan
Publikováno v:
Systematic Reviews, Vol 11, Iss 1, Pp 1-10 (2022)
Abstract Background The mutant allele (*2) of aldehyde dehydrogenase type 2 (ALDH2) caused by a single nucleotide variant (rs671) inhibits enzymatic activity and is associated with multiple diseases. In recent years, an explosive number of original s
Externí odkaz:
https://doaj.org/article/c458830ecffa41468f358f4cce88f8a1
Autor:
Lijing L. Yan, Chaoyun Li, Siyu Zou, Yaxi Li, Enying Gong, Zhengting He, Shuai Shao, Xurui Jin, Yechu Hua, John A. Gallis, Elizabeth L. Turner
Publikováno v:
International Journal of Behavioral Nutrition and Physical Activity, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Background There is little evidence of the influence of dietary patterns on mortality risk among adults 80 years or older (“oldest-old”). We evaluated the association between the Simplified Healthy Eating index (SHE-index) and mortality
Externí odkaz:
https://doaj.org/article/a38fbbccc4b24323a973c8b2020f995f
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Backgrounds Emerging evidence suggested that indoor air pollution caused long-term adverse effects on cognitive function among older adults who spend more than 85% of their time indoors. Although high indoor ventilation can mitigate the effe
Externí odkaz:
https://doaj.org/article/abf62390b31b4cf2a5457296ba3a316a
Autor:
Yuzhu Gao, William Robert Kwapong, Yifan Zhang, Yuying Yan, Xurui Jin, Yunhan Tao, Hanyue Xu, Bo Wu, Ming Zhang
Publikováno v:
BMC Ophthalmology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Backgro To assess the microvascular changes in the macular region and the foveal avascular zone (FAZ) area in participants with white matter hyperintensities (WMHs) using swept source optical coherence tomography angiography (SS OCTA). Metho
Externí odkaz:
https://doaj.org/article/8b6ffe6e99514b5fb377006a9765e783
Autor:
Xingxing Chen, Wenfan Wu, Xian Zhang, Tingxi Long, Wenyu Zhu, Rundong Hu, Xurui Jin, Lijing L. Yan, Yao Yao
Publikováno v:
Epidemiology and Health, Vol 44 (2022)
OBJECTIVES Previous studies have established associations of cognitive function and leisure activities with mortality. This study aimed to evaluate whether leisure activities causally mediate these associations. METHODS This longitudinal study includ
Externí odkaz:
https://doaj.org/article/e5b5151968124434a1a4a890fa04a1ac
Autor:
Fang Wu, Shuting Jin, Yinghui Jiang, Xurui Jin, Bowen Tang, Zhangming Niu, Xiangrong Liu, Qiang Zhang, Xiangxiang Zeng, Stan Z. Li
Publikováno v:
Advanced Science, Vol 9, Iss 33, Pp n/a-n/a (2022)
Abstract The latest biological findings observe that the motionless “lock‐and‐key” theory is not generally applicable and that changes in atomic sites and binding pose can provide important information for understanding drug binding. However,
Externí odkaz:
https://doaj.org/article/e56f083b9c9b4389815dd5424124dbbe
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
Recent literature suggested that ALDH2 mutation is associated with alcohol metabolism, and ethanol intake might jointly increase the risk of Alzheimer’s disease (AD) in mice. However, it is unclear whether this synergistic effect exists among human
Externí odkaz:
https://doaj.org/article/4abaaae64d99436a8836a2442f6f6c7e