MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection

Autor: Xuqiu Lei, Yongzhi Chen, Egil Lien, Katherine A. Fitzgerald

Publikováno v: mBio, Vol 14, Iss 2 (2023)

ABSTRACT Influenza A virus (IAV) triggers multiple programmed cell death pathways, including MLKL-dependent necroptosis, caspase-8-dependent apoptosis, and caspase-1-dependent pyroptosis in myeloid cells. All three pathways share common upstream regu

Externí odkaz: https://doaj.org/article/93fdbd31f3b54dc697717c87b6b58c80

Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.

Autor: Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang, Humphries, Fiachra, Parsi, Krishna Mohan, Mustone, Nicholas J., Ramos, Irene, Mutetwa, Tinaye, Fernandez-Sesma, Ana, Maehr, René, Caffrey, Daniel R., Fitzgerald, Katherine A.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 11/21/2023, Vol. 120 Issue 47, p1-9, 21p

The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2

Autor: Tim Vierbuchen, Shiuli Agarwal, John L. Johnson, Liraz Galia, Xuqiu Lei, Karina Stein, David Olagnier, Karoline I. Gaede, Christian Herzmann, Christian K. Holm, Holger Heine, Athma Pai, Aisling O’Hara Hall, Kasper Hoebe, Katherine A. Fitzgerald

Publikováno v: Vierbuchen, T, Agarwal, S, Johnson, J L, Galia, L, Lei, X, Stein, K, Olagnier, D, Gaede, K I, Herzmann, C, Holm, C K, Heine, H, Pai, A, O'Hara Hall, A, Hoebe, K & Fitzgerald, K A 2023, ' The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2 ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 1, pp. e2213715120 . https://doi.org/10.1073/pnas.2213715120

The nuclear long non-coding RNA LUCAT1 has previously been identified as a negative feedback regulator of type I interferon and inflammatory cytokine expression in human myeloid cells. Here, we define the mechanistic basis for the suppression of infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119871f4c6d7df23af628c24378908e
https://pubmed.ncbi.nlm.nih.gov/36577072

CNBP restricts SARS-CoV2 by regulating IFN and disrupting RNA-protein condensates

Autor: Katherine Fitzgerald, Yongzhi Chen, Xuqiu Lei, Zhaozhao Jiang, Fiachra Humphries, Nicholas Mustone, Irene Ramos, Tinaye Mutetwa, Ana Fernandez-Sesma

Publikováno v: Research square.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades antiviral immunity through the expression of viral proteins that block detection, signaling, interferon (IFN) induction, and IFN-stimulated gene (ISG) expression. Weak induction of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2870e04625f18d6c4164d203c526a9
https://pubmed.ncbi.nlm.nih.gov/35547851

Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

Autor: Xuqiu Lei, Khaja Muneeruddin, Ruth Wilson, Simona Ceglia, Fiachra Humphries, Liraz Shmuel-Galia, Katherine A. Fitzgerald, Scott A. Shaffer, JeanMarie Houghton, Doyle V. Ward, Andrea Reboldi, Natália Ketelut-Carneiro, Susanne Pechhold, Sage E. Foley, Beth A. McCormick, Zhaozhao Jiang, Ann Marshak-Rothstein

Publikováno v: Immunity

Alterations in the cGAS-STING DNA-sensing pathway affect intestinal homeostasis. We sought to delineate the functional role of STING in intestinal inflammation. Increased STING expression was a feature of intestinal inflammation in mice with colitis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9239fdfa34273aa964902f67565723
https://pubmed.ncbi.nlm.nih.gov/34051146