Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Xupeng Hong"'
Autor:
Yansheng Ye, Erin R. Tyndall, Van Bui, Maria C. Bewley, Guifang Wang, Xupeng Hong, Yang Shen, John M. Flanagan, Hong-Gang Wang, Fang Tian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Autophagosome formation, a crucial step in macroautophagy (autophagy), requires the covalent conjugation of LC3 proteins to the amino headgroup of phosphatidylethanolamine (PE) lipids. Atg3, an E2-like enzyme, catalyzes the transfer of LC3 f
Externí odkaz:
https://doaj.org/article/a99d2af0ebbf4d8aa6cb31f0ecb77bd6
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Hepatitis B virus (HBV) precore protein is not essential for viral replication but is thought to facilitate chronic infection. In addition to the secreted precore products, including the hepatitis B e antigen (HBeAg) and PreC protein, intrac
Externí odkaz:
https://doaj.org/article/7b687b5aeeaa4b8ca25854f588c67730
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010739 (2022)
Hepadnaviruses use extensively overlapping genes to expand their coding capacity, especially the precore/core genes encode the precore and core proteins with mostly identical sequences but distinct functions. The precore protein of the woodchuck hepa
Externí odkaz:
https://doaj.org/article/5c134db75cfe4b6d91be790142c54008
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010633 (2022)
Hepatitis B virus (HBV) has a highly restricted host range and cell tropism. Other than the human sodium taurocholate cotransporting polypeptide (huNTCP), the HBV entry receptor, host determinants of HBV susceptibility are poorly understood. Woodchuc
Externí odkaz:
https://doaj.org/article/1b7c3cf7e1d54d25a1c4314317a90c45
Autor:
Steffen Wildum, Kyle E. Korolowicz, Manasa Suresh, Guido Steiner, Lue Dai, Bin Li, Changsuek Yon, Maria Cristina De Vera Mudry, Franziska Regenass-Lechner, Xu Huang, Xupeng Hong, Marta G. Murreddu, Bhaskar V. Kallakury, John A. T. Young, Stephan Menne
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Conventional treatment of chronic hepatitis B (CHB) is rarely curative due to the immunotolerant status of patients. RG7854 is an oral double prodrug of a toll-like receptor 7 (TLR7) agonist that is developed for the treatment of CHB. The therapeutic
Externí odkaz:
https://doaj.org/article/a04b8aaec71a4c08ac4faee905c728d1
Publikováno v:
Viruses, Vol 15, Iss 3, p 642 (2023)
Hepatitis B virus (HBV) relies on the core protein (HBc) to establish productive infection, as defined by the formation of the covalently closed circularized DNA (cccDNA), as well as to carry out almost every step of the lifecycle following cccDNA fo
Externí odkaz:
https://doaj.org/article/0fb410cf110648968bee4ab369d764d2
Autor:
Stephan Menne, Steffen Wildum, Guido Steiner, Manasa Suresh, Kyle Korolowicz, Maria Balarezo, Changsuek Yon, Marta Murreddu, Xupeng Hong, Bhaskar V. Kallakury, Robin Tucker, Song Yang, John A.T. Young, Hassan Javanbakht
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 916-931 (2020)
RG7834 is a small‐molecule inhibitor of hepatitis B virus (HBV) gene expression that significantly reduces the levels of hepatitis B surface antigen (HBsAg) and HBV DNA in a humanized liver HBV mouse model. In the current study, we evaluated the po
Externí odkaz:
https://doaj.org/article/e6ff35ac4bb1484d80f8c4112e1fa688
Autor:
Yansheng Ye, Erin R. Tyndall, Van Bui, Maria C. Bewley, Guifang Wang, Xupeng Hong, Yang Shen, John M. Flanagan, Hong-Gang Wang, Fang Tian
Autophagosome formation is the hallmark of macroautophagy (herein referred to as autophagy) and requires the covalent conjugation of LC3 proteins (or Atg8 in yeast) to the amino headgroup of PE (phosphatidylethanolamine) lipids. Atg3 is an enzyme tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::470ac8b33927d1b5d953495c49c0835f
https://doi.org/10.1101/2022.12.23.521840
https://doi.org/10.1101/2022.12.23.521840
Publikováno v:
Science Advances. 8
The loss of detectable hepatitis B surface antigen (HBsAg) is considered a functional cure in chronic hepatitis B. Naturally, HBsAg can be incorporated into the virion envelope or assembled into subviral particles (SVPs) with lipid from host cells. U
Autor:
Stephan Menne, Stefan Wieland, David H. Perlman, Peter Revill, Jianming Hu, Laurie Luckenbaugh, Xupeng Hong
Publikováno v:
Hepatology
BACKGROUND AND AIMS The hepatitis B core-related antigen (HBcrAg), a composite antigen of precore/core gene including classical hepatitis B core protein (HBc) and HBeAg and, additionally, the precore-related antigen PreC, retaining the N-terminal sig