Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Xunzhe Yin"'
Therapeutic potential of ASK1 activators in cancer treatment: Current insights and future directions
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117214- (2024)
Apoptosis signal-regulated kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase (MAP3K) family, whose activation and regulation are intricately associated with apoptosis. ASK1 is activated in response to oxidative stress, among
Externí odkaz:
https://doaj.org/article/008d9042ae1647d8b83f1564007d11b2
Publikováno v:
Journal of Geodesy and Geoinformation Science, Vol 6, Iss 4, Pp 48-69 (2023)
During a long-term Equatorial Plasma Bubbles (EPBs) occurrence between October 2020 and March 2021, a significant EPB suppression event was identified on November 22 and the observations from multi-instrument have been utilized to investigate this ev
Externí odkaz:
https://doaj.org/article/f8a949506175438ab3137520731268cb
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Transferrin (Tf), widely known for its role as an iron-binding protein, exemplifies multitasking in biological processes. The role of Tf in iron metabolism involves both the uptake of iron from Tf by various cells, as well as the endocytosis mediated
Externí odkaz:
https://doaj.org/article/6189523986d844ceae245edf917602a0
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108614- (2024)
Summary: Hepatic steatosis, which is triggered by dysregulation of lipid metabolism and redox equilibrium in the liver, is regarded as a risk factor in the non-alcoholic fatty liver disease (NAFLD). However, pharmacologic engagement of this process i
Externí odkaz:
https://doaj.org/article/73031c51ffb74304a3e94f2891568d3c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immunotherapy is a therapeutic approach that employs immunological principles and techniques to enhance and amplify the body’s immune response, thereby eradicating tumor cells. Immunotherapy has demonstrated effective antitumor effects on a variety
Externí odkaz:
https://doaj.org/article/c229716ca1a947dfa246c2ef8bdfbfe3
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 1, p 30 (2024)
Metabolic dysfunction-associated steatotic liver disease (MASLD) has a global prevalence of 25% and is a leading cause of cirrhosis and hepatocellular carcinoma. The prevalence of MASLD has been increasing, mirroring the global increase in diabetes a
Externí odkaz:
https://doaj.org/article/6cf134e8259044c5a5dbd9cbb3f1af90
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 12, p 332 (2023)
Nonalcoholic fatty liver disease (NAFLD) constitutes a commonly diagnosed liver pathology with perturbed lipid metabolism, which is mainly caused by excessive accumulation of fat in hepatocytes by various pathogenic factors. Currently, there are no e
Externí odkaz:
https://doaj.org/article/6d05b99a9463401bb925666a299cd52f
Autor:
Jiaxin Zhang, Zuojia Liu, Wenjing Zhao, Xunzhe Yin, Xiliang Zheng, Chuanbo Liu, Jin Wang, Erkang Wang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
HRas-GTP has a transient intermediate state with a “non-signaling open conformation” in GTP hydrolysis and nucleotide exchange. Due to the same hydrolysis process and the structural homology, it can be speculated that the active KRas adopts the s
Externí odkaz:
https://doaj.org/article/23c59e8d2788459b8baa9d70dc8a5b25
Publikováno v:
Atmosphere, Vol 14, Iss 2, p 335 (2023)
The spatiotemporal variations and mechanisms of the ionospheric storms over the American sector during the August 2018 geomagnetic storm are investigated. One positive and one negative ionospheric storm occurred in North America and two positive stor
Externí odkaz:
https://doaj.org/article/75607e5db1de45b497b86130ddcab43d
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2844 (2023)
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease that affects approximately one-quarter of the global adult population, posing a significant threat to human health with wide-ranging social and economic implication
Externí odkaz:
https://doaj.org/article/5f1f709365514d8d8697ebf453830616