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Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
Autor:
Junke Liu, Hengmin Tang, Chanjuan Xu, Shengnan Zhou, Xunying Zhu, Yuanyuan Li, Laurent Prézeau, Tao Xu, Jean-Philippe Pin, Philippe Rondard, Wei Ji, Jianfeng Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The functional consequence of G protein-coupled receptor oligomerization remains debated. Here the authors show that platelet-activating factor receptor oligomerization enhances G protein coupling, and restrains β-arrestin recruitment and internaliz
Externí odkaz:
https://doaj.org/article/a97813f6a8c84e5398c5ec28ca06bef1
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor
Autor:
Junke Liu, Hengmin Tang, Chanjuan Xu, Shengnan Zhou, Xunying Zhu, Yuanyuan Li, Laurent Prézeau, Tao Xu, Jean-Philippe Pin, Philippe Rondard, Wei Ji, Jianfeng Liu
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.6365. ⟨10.1038/s41467-022-34056-4⟩
Nature Communications, 2022, 13 (1), pp.6365. ⟨10.1038/s41467-022-34056-4⟩
G protein-coupled receptors (GPCRs) are important drug targets that mediate various signaling pathways by activating G proteins and engaging β-arrestin proteins. Despite its importance for the development of therapeutics with fewer side effects, the