Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Xunde Xian"'
Autor:
Jingjing Guo, Huining Gu, Sha Yin, Jiongming Yang, Qianqian Wang, Weiyan Xu, Yifan Wang, Shenghua Zhang, Xiaofeng Liu, Xunde Xian, Xiaoyan Qiu, Jing Huang
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background Lipid metabolism dysregulation is a key characteristic of hepatocellular carcinoma (HCC) onset and progression. Elevated expression of immunoglobulin (Ig), especially the Igκ free light chain with a unique Vκ4-1/Jκ3 rearrangeme
Externí odkaz:
https://doaj.org/article/6777b21cbaf64e45a0bc87336879f530
Autor:
Xiao Lin, Wei Zhang, Chun Yang, Ping Ma, Kunxiang He, Gonglie Chen, Yijun Tao, Haizhao Yan, Zhao Yang, Ling Zhang, Jianglin Fan, Qinghua Cui, Wei Huang, George Liu, Xunde Xian, Yuhui Wang
Publikováno v:
Journal of Advanced Research, Vol 63, Iss , Pp 187-194 (2024)
Introduction: Lecithin cholesterol acyltransferase (LCAT) plays a crucial role in acyl-esterifying cholesterol in plasma, which is essential for reverse cholesterol transport (RCT). Previous studies indicated that its activity on both α and β lipop
Externí odkaz:
https://doaj.org/article/a0456a97b5034102a572f04050f67524
Autor:
Xinzhu Shan, Zhiqiang Zhao, Pingping Lai, Yuxiu Liu, Buyao Li, Yubin Ke, Hanqiu Jiang, Yilong Zhou, Wenzhe Li, Qian Wang, Pengxia Qin, Yizhe Xue, Zihan Zhang, Chenlong Wei, Bin Ma, Wei Liu, Cong Luo, Xueguang Lu, Jiaqi Lin, Li Shu, Yin Jie, Xunde Xian, Derfogail Delcassian, Yifan Ge, Lei Miao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) poses challenges for targeted delivery and retention of therapeutic proteins due to excess extracellular matrix (ECM). Here we present a new approach to treat MASH, termed “Fibrosis o
Externí odkaz:
https://doaj.org/article/0785cca37b8448b3871d710ded444c5d
Autor:
Xunde Xian, Yinyuan Ding, Marco Dieckmann, Li Zhou, Florian Plattner, Mingxia Liu, John S Parks, Robert E Hammer, Philippe Boucher, Shirling Tsai, Joachim Herz
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/e0bff3f517564c15ad5bbbe1b5a7648e
Autor:
Guolin Miao, Jiabao Guo, Wenxi Zhang, Pingping Lai, Yitong Xu, Jingxuan Chen, Lianxin Zhang, Zihao Zhou, Yufei Han, Gonglie Chen, Jinxuan Chen, Yijun Tao, Lemin Zheng, Ling Zhang, Wei Huang, Yuhui Wang, Xunde Xian
Publikováno v:
Research, Vol 7 (2024)
Combined hyperlipidemia (CHL) manifests as elevated cholesterol and triglycerides, associated with fatty liver and cardiovascular diseases. Emerging evidence underscores the crucial role of the intestinal microbiota in metabolic disorders. However, t
Externí odkaz:
https://doaj.org/article/b6c3763a68b0461881c46d474f3e4cfb
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/a2a6719e749f4d588749915d3e6a43eb
Autor:
Haozhe Shi, Jiabao Guo, Qiongyang Yu, Xinlin Hou, Lili Liu, Mingming Gao, Lili Wei, Ling Zhang, Wei Huang, Yuhui Wang, George Liu, Peter Tontonoz, Xunde Xian
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Interleukin-10 (IL-10) is a widely recognized immunosuppressive factor. Although the concept that IL-10 executes an anti-inflammatory role is accepted, the relationship between IL-10 and atherosclerosis is still unclear, thus limiting the application
Externí odkaz:
https://doaj.org/article/6a35711770d546de9ea05dd043620570
Autor:
Chun Yang, Wenhong Tian, Sisi Ma, Mengmeng Guo, Xiao Lin, Fengying Gao, Xiaoyan Dong, Mingming Gao, Yuhui Wang, George Liu, Xunde Xian
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 692-701 (2020)
Apolipoprotein C2 (ApoC2) is a key activator of lipoprotein lipase for plasma triglyceride metabolism. ApoC2-deficient patients present with severe hypertriglyceridemia and recurrent acute pancreatitis, for whom the only effective treatment is the in
Externí odkaz:
https://doaj.org/article/bd674971513648498f018661c7ddcf8e
Autor:
Yitong Xu, Jiabao Guo, Ling Zhang, Guolin Miao, Pingping Lai, Wenxi Zhang, Lili Liu, Xinlin Hou, Yuhui Wang, Wei Huang, George Liu, Mingming Gao, Xunde Xian
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
RationaleApoC3 plays a central role in the hydrolysis process of triglyceride (TG)-rich lipoproteins mediated by lipoprotein lipase (LPL), which levels are positively associated with the incidence of cardiovascular disease (CVD). Although targeting A
Externí odkaz:
https://doaj.org/article/bc4874f3c70544ccb3dc331c200bbbd8
Autor:
Xiao Lin, Ping Ma, Chun Yang, Jinjie Wang, Kunxiang He, Gonglie Chen, Wei Huang, Jianglin Fan, Xunde Xian, Yuhui Wang, George Liu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Elevated triglycerides are associated with an increased risk of cardiovascular disease (CVD). Therefore, it is very important to understand the metabolism of triglyceride-rich lipoproteins (TRLs) and their atherogenic role in animal models. Using low
Externí odkaz:
https://doaj.org/article/3c1adf6e2d0c4e18a1f21d73bcb7d95a