Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Xunde Wang"'
Autor:
Xunde Wang, Kate Gardner, Mickias B. Tegegn, Clifton L. Dalgard, Camille Alba, Stephan Menzel, Hamel Patel, Mehdi Pirooznia, Yi-Ping Fu, Fayaz T. Seifuddin, Swee Lay Thein
Publikováno v:
Blood Advances. 6:3535-3540
Acute pain, the most prominent complication of sickle cell disease (SCD), results from vaso-occlusion triggered by sickling of deoxygenated red blood cells (RBCs). Concentration of 2,3-diphosphoglycerate (2,3-DPG) in RBCs promotes deoxygenation by pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692f0da70b992b502cab67e30e98afce
https://doi.org/10.1182/bloodadvances.2021006668
https://doi.org/10.1182/bloodadvances.2021006668
Autor:
Hyokyoung G Hong, Mateus H Gouveia, Martin Ogwang, Patrick Kerchan, Steven Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa, Nestory Masalu, Esther Kawira, Tobias Kinyera, Xunde Wang, Jiefu Zhou, Isaac Otim, Ismail D Legason, Hadijah Nabalende, Herry Dhudha, Mediatrix Mumia, Francine G Baker, Temi Okusolubo, Leona W Ayers, Kishor Bhatia, James J Goedert, Joshua G Woo, Nathan Cole, Wen Luo, Belynda Hicks, Adebowale A Adeyemo, Ludmila Prokunina-Olsson, Daniel N. Shriner, Charles N Rotimi, George Chagaluka, W Thomas Johnston, Nora Mutalima, Eric Borgstein, George N Liomba, Steve Kamiza, Nyengo Mkandawire, Collins Mitambo, Elizabeth Molyneux, Robert Newton, Michelle Manning, Joseph F Fraumeni, Ruth M Pfeiffer, Amy Hutchinson, Meredith Yeager, Swee Lay Thein, Stephen J. Chanock, Sam M. Mbulaiteye
Publikováno v:
Blood. 140:9314-9316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edc56c3c20233154b0ad454751d1c120
https://doi.org/10.1182/blood-2022-170410
https://doi.org/10.1182/blood-2022-170410
Autor:
Xunde Wang, Yi-Ping Fu, Quan Li, Emily B Dunkelberger, Mickias Tegegn, Penelope A. Kosinski, Heidi Mangus, John Hamre, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson, Stephen J. Chanock, Nancy Asomaning, Neal Jeffries, William Eaton, Swee Lay Thein
Publikováno v:
Blood. 140:954-956
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9301e87c4e38acaa9801a4459c25c758
https://doi.org/10.1182/blood-2022-167296
https://doi.org/10.1182/blood-2022-167296
Autor:
Maureen Lundt, Nancy Asomaning, Ingrid Frey, Xunde Wang, Anna Conrey, Julia Z Xu, Quan Li, Emily B Dunkelberger, Neal Jeffries, William Eaton, Swee Lay Thein
Publikováno v:
Blood. 140:2508-2509
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b76f1f246cf65b23e4c949e6f68d527a
https://doi.org/10.1182/blood-2022-170010
https://doi.org/10.1182/blood-2022-170010
Autor:
Kang Le, Xunde Wang, Maureen Lundt, Anna Conrey, Ingrid Frey, Silvia Giannini, Penelope A. Kosinski, John A. Hausman, Philip S. Low, Neal Jeffries, Swee Lay Thein
Publikováno v:
Blood. 140:5395-5396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::589154b9aa49de8253dddf2926d1fbb7
https://doi.org/10.1182/blood-2022-160378
https://doi.org/10.1182/blood-2022-160378
Autor:
Zenaide M.N. Quezado, Sayuri Kamimura, Meghann Smith, Xunde Wang, Michael R. Heaven, Sirsendu Jana, Sebastian Vogel, Patricia Zerfas, Christian A. Combs, Luis E.F. Almeida, Quan Li, Martha Quezado, Iren Horkayne-Szakaly, Penelope A. Kosinski, Shaoxia Yu, Unnati Kapadnis, Charles Kung, Lenny Dang, Paul Wakim, William A. Eaton, Abdu I. Alayash, Swee Lay Thein
Publikováno v:
Blood Cells Mol Dis
Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, factors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fae3b20d22c75bd489e292ed02baa27
https://doi.org/10.1016/j.bcmd.2022.102660
https://doi.org/10.1016/j.bcmd.2022.102660
Autor:
Sebastian Vogel, Swee Lay Thein, Zenaide M.N. Quezado, James S. Nichols, Taruna Arora, Laurel Mendelsohn, Xunde Wang, Arun S. Shet, Darlene Allen, Christian A. Combs
Publikováno v:
Blood Advances. 2:2672-2680
A key inflammatory mechanism recently identified in platelets involves the Nod-like receptor nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK), which control activation of caspase-1 within inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26406e723e23bfe96d742ca16d17b5e5
https://doi.org/10.1182/bloodadvances.2018021709
https://doi.org/10.1182/bloodadvances.2018021709
Autor:
Xunde Wang, Mehdi Pirooznia, Fayaz Seifuddin, Stephan Menzel, Kate Gardner, Neal Jeffries, Swee Lay Thein, Mickias Tegegn, Hamel Patel, Yi-Ping Fu
Publikováno v:
Blood. 138:953-953
Background: Acute pain, the most prominent complication of sickle cell disease (SCD), results from vasoocclusion triggered by sickling of deoxygenated red blood cells (RBCs). A key factor influencing HbS oxygenation is the intracellular concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4d10f576d8ebdce964224db17a22021
https://doi.org/10.1182/blood-2021-151842
https://doi.org/10.1182/blood-2021-151842
Publikováno v:
Blood. 136:13-14
Background Sickle Cell Disease (SCD) is a genetic disorder caused by a single amino acid substitution in the ß-hemoglobin chain. Clinical manifestations of SCD are multisystemic and heterogeneous, with a wide range of organ damage between patients d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9331369c9cf18aa3826cf2e33a8176b5
https://doi.org/10.1182/blood-2020-139382
https://doi.org/10.1182/blood-2020-139382
Autor:
Swee Lay Thein, Xunde Wang
Publikováno v:
Nature Genetics. 50:478-480
The switch from fetal to adult hemoglobin relies on repression or silencing of the upstream γ-globin gene, but identification of the transcriptional repressors that bind to the sites at which a cluster of naturally occurring variants associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a9a3dfbff455fe2b791059435ec0fd
https://doi.org/10.1038/s41588-018-0094-z
https://doi.org/10.1038/s41588-018-0094-z