Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Xun-Ling Zhang"'
Publikováno v:
Somatic cell and molecular genetics. 19(1)
It is now clear that the lysosomal hydrolysis of sphingolipids requires both lysosomal enzymes and so-called sphingolipid activator proteins (SAPs). One gene, called prosaposin, codes for a precursor protein that is proteolytically cut into four puta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315057fe57a57ec65de8460dd1cc7868
https://pubmed.ncbi.nlm.nih.gov/8460394
https://pubmed.ncbi.nlm.nih.gov/8460394
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 87(4)
The lysosomal catabolism of sulfatide requires arylsulfatase A and a specific sphingolipid activator protein, SAP-1. While most patients with metachromatic leukodystrophy have mutations in the gene for arylsulfatase A, some patients have deficient SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0491f32b85785ca31fe56c5813c62
https://pubmed.ncbi.nlm.nih.gov/1689485
https://pubmed.ncbi.nlm.nih.gov/1689485
Publikováno v:
Biochemical and biophysical research communications. 166(2)
The lysosomal degradation of sulfatide requires the specific enzyme, arylsulfatase A, as well as a heat stable protein called sphingolipid activator protein-1 (SAP-1). While most patients with metachromatic leukodystrophy have defects in arylsulfatas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da108902210258c572ba77396c523f46
https://pubmed.ncbi.nlm.nih.gov/2302219
https://pubmed.ncbi.nlm.nih.gov/2302219
Autor:
John S. O'Brien, David A. Wenger, Judith A. Hartz, Xun-Ling Zhang, Fa-Ten Kao, Carol Jones, Nazneen N. Dewji, Martha Liao Law
Publikováno v:
Somatic cell and molecular genetics. 13(6)
Sphingolipid activator protein SAP-1 is required for the enzymatic hydrolysis of GMI ganglioside and sulfatide. The gene coding for SAP-1 was previously mapped to human chromosome 10 using monospecific antibodies prepared against SAP-1 in synteny ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7d2d0c3eef8afe7da27d56cc2da487
https://pubmed.ncbi.nlm.nih.gov/3478817
https://pubmed.ncbi.nlm.nih.gov/3478817
Publikováno v:
Lipid Storage Disorders ISBN: 9781461283003
The catabolism of sulfatide, GM1 ganglioside and ceramide trihexoside require a heat stable activator protein in addition to their specific lysosomal enzyme.1-3 This so-called sphingolipid activator protein (SAP-1 in our nomenclature4) acts by bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb07a76214822aa0abd58fe83d6560fe
https://doi.org/10.1007/978-1-4613-1029-7_41
https://doi.org/10.1007/978-1-4613-1029-7_41
