Zobrazeno 1 - 10
of 831
pro vyhledávání: '"Xun Lu"'
Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation. While the activation mechanism for monomeric GPCRs has been well-established,
Externí odkaz:
https://doaj.org/article/39581e53858b473cb5cb3cd8bbfd4905
Autor:
Wenbin Fan, Qing-Ying Luo, Xun Lu, Qing Xie, Qunzeng Danzeng, Yiqian Zhang, Song Jin, Wen-Xiang Cheng, Cui Liu
Publikováno v:
ACS Omega, Vol 9, Iss 26, Pp 28666-28675 (2024)
Externí odkaz:
https://doaj.org/article/c1a776037f444bd1a1e91b815e03ccd3
Publikováno v:
Ecology and Evolution, Vol 14, Iss 10, Pp n/a-n/a (2024)
ABSTRACT The oligotrophic tropical western Pacific region is characterized by a high density of seamounts, with the Kyushu‐Palau Ridge (KPR) being the longest seamount chain here. Effective spatial management plans for seamount ecosystems necessita
Externí odkaz:
https://doaj.org/article/fa7d48d3da9646d09fbd36430538ded5
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-43 (2024)
Abstract G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric
Externí odkaz:
https://doaj.org/article/c65fe5256d1847518e22a73b617bb91a
Autor:
Yumin Liu, Linjuan Shi, Yifan Chen, Sifan Luo, Yuehang Chen, Hongtian Chen, Wenlang Lan, Xun Lu, Zhan Cao, Zehua Ye, Jinping Li, Bo Yu, Elaine Dzierzak, Zhuan Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract An understanding of the mechanisms regulating embryonic hematopoietic stem cell (HSC) development would facilitate their regeneration. The aorta-gonad-mesonephros region is the site for HSC production from hemogenic endothelial cells (HEC).
Externí odkaz:
https://doaj.org/article/b0404ef03301401caf800eeb999f01ab
Autor:
Yue Gao, Xun Lu, Guangyuan Zhang, Chunhui Liu, Si Sun, Weipu Mao, Guiya Jiang, Yu Zhou, Nieke Zhang, Shuchun Tao, Ming Chen, Shuqiu Chen, Lei Zhang
Publikováno v:
Redox Biology, Vol 70, Iss , Pp 103078- (2024)
Acute kidney injury (AKI) is a life-threatening health condition associated with increasing morbidity and mortality. Despite extensive research on the mechanisms underlying AKI, effective clinical tools for prediction and treatment remain scarce. Oxi
Externí odkaz:
https://doaj.org/article/db42d4d5eb524319830612a87b0b4262
Platelet-derived extracellular vesicles are associated with kidney injury in patients with urosepsis
Publikováno v:
Molecular and Cellular Probes, Vol 73, Iss , Pp 101949- (2024)
Background: There is increasing evidence that platelet-derived extracellular vesicles (PEVs) may be involved in the mechanisms of inflammatory storm and organ damage in sepsis. However, there are no available studies on PEVs and renal injury in patie
Externí odkaz:
https://doaj.org/article/e5945184900e49d484b3f64a2a54a61e
Publikováno v:
Remote Sensing, Vol 16, Iss 10, p 1767 (2024)
Hydraulic infrastructures are susceptible to deformation over time, necessitating reliable monitoring and prediction methods. In this study, we address this challenge by proposing a novel approach based on the combination of Variational Mode Decompos
Externí odkaz:
https://doaj.org/article/722f73e5a29843c3a4fbf8f9312562ab
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115391- (2023)
Background: Orthodontic tooth movement (OTM) is a typical treatment that corrects malaligned teeth by applying mechanical forces. However, mechanical overload often leads to damage of PDL fibroblasts. Sanhuang decoction (SHD) is commonly used to inhi
Externí odkaz:
https://doaj.org/article/d860827b60e04257bb8debfc4bc49adf
Publikováno v:
Health Data Science, Vol 3 (2023)
Importance: Allosteric drugs bound to topologically distal allosteric sites hold a substantial promise in modulating therapeutic targets deemed undruggable at their orthosteric sites. Traditionally, allosteric modulator discovery has predominantly re
Externí odkaz:
https://doaj.org/article/744f1ff3b77a4ffd9a2a1b13986e78a3