Zobrazeno 1 - 10
of 774
pro vyhledávání: '"Xun, Lu"'
Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation. While the activation mechanism for monomeric GPCRs has been well-established,
Externí odkaz:
https://doaj.org/article/39581e53858b473cb5cb3cd8bbfd4905
Autor:
Wenbin Fan, Qing-Ying Luo, Xun Lu, Qing Xie, Qunzeng Danzeng, Yiqian Zhang, Song Jin, Wen-Xiang Cheng, Cui Liu
Publikováno v:
ACS Omega, Vol 9, Iss 26, Pp 28666-28675 (2024)
Externí odkaz:
https://doaj.org/article/c1a776037f444bd1a1e91b815e03ccd3
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-43 (2024)
Abstract G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric
Externí odkaz:
https://doaj.org/article/c65fe5256d1847518e22a73b617bb91a
Autor:
Yumin Liu, Linjuan Shi, Yifan Chen, Sifan Luo, Yuehang Chen, Hongtian Chen, Wenlang Lan, Xun Lu, Zhan Cao, Zehua Ye, Jinping Li, Bo Yu, Elaine Dzierzak, Zhuan Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract An understanding of the mechanisms regulating embryonic hematopoietic stem cell (HSC) development would facilitate their regeneration. The aorta-gonad-mesonephros region is the site for HSC production from hemogenic endothelial cells (HEC).
Externí odkaz:
https://doaj.org/article/b0404ef03301401caf800eeb999f01ab
Publikováno v:
Global Ecology and Conservation, Vol 55, Iss , Pp e03239- (2024)
Desert plant communities play a crucial role in enhancing desert ecosystem productivity and stability but are highly susceptible to environmental changes owing to their limited resilience and resistance to disturbances, making it essential to underst
Externí odkaz:
https://doaj.org/article/c070df55c4c9490da2acfc62a0f9c0aa
Autor:
Cui Ma, Aierxiding Abulikemu, Xun‐Lu Li, Ya Zhang, Qian Cheng, Yao‐Guo Fang, Jian Bao, Rui‐Jie Luo, Chong‐Yu Du, Jie Zeng, Xuan Xu, Yuan‐He Sun, Yue‐Liang Gu, Yoshiharu Uchimoto, Yong‐Ning Zhou
Publikováno v:
Small Structures, Vol 5, Iss 7, Pp n/a-n/a (2024)
Honeycomb‐layered oxides are a class of cathode materials for sodium‐ion batteries with great potential due to their high voltage and high capacity. However, the structural instability and voltage fading during cycling limit their practical appli
Externí odkaz:
https://doaj.org/article/f2562c64f2c54c6fb12aa69bbf5b26c6
Autor:
Wen-Xun Lu, Guang-Yuan Rao
Publikováno v:
MethodsX, Vol 12, Iss , Pp 102608- (2024)
Species distribution models (SDMs) are powerful tools that can predict potential distributions of species under climate change. However, traditional SDMs that rely on current species occurrences may underestimate their climatic tolerances and potenti
Externí odkaz:
https://doaj.org/article/a5ed93d976a642e08a16cce278c3d288
Autor:
Shukla, Dharma, Sivathanu, Muthian, Viswanatha, Srinidhi, Gulavani, Bhargav, Nehme, Rimma, Agrawal, Amey, Chen, Chen, Kwatra, Nipun, Ramjee, Ramachandran, Sharma, Pankaj, Katiyar, Atul, Modi, Vipul, Sharma, Vaibhav, Singh, Abhishek, Singhal, Shreshth, Welankar, Kaustubh, Xun, Lu, Anupindi, Ravi, Elangovan, Karthik, Rahman, Hasibur, Lin, Zhou, Seetharaman, Rahul, Xu, Cheng, Ailijiang, Eddie, Krishnappa, Suresh, Russinovich, Mark
Lowering costs by driving high utilization across deep learning workloads is a crucial lever for cloud providers. We present Singularity, Microsoft's globally distributed scheduling service for highly-efficient and reliable execution of deep learning
Externí odkaz:
http://arxiv.org/abs/2202.07848
Autor:
Zhang, Hao, Li, Qiubo, Xu, Xinyue, Yang, Hui, Li, Guodong, Liu, Zhaolu, Liao, Mochou, Xu, Jie, Li, Xun-Lu, Wang, Nan, Zhang, Junxi, Peng, Haoyang, Cao, Yongjie
Publikováno v:
In Journal of Colloid And Interface Science 15 January 2025 678 Part B:20-29
Publikováno v:
IEEE Photonics Journal, Vol 16, Iss 2, Pp 1-5 (2024)
We design and experimentally demonstrate compact and robust adiabaticity engineered couplers (AECs) with design intended splitting ratios (SRs) for the silicon-on-insulator platform. Adiabatic couplers (ACs) with variable SRs can be designed by outpu
Externí odkaz:
https://doaj.org/article/6280d96ce86f4b4297e82d5fdf9cc012