Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Xuguang Zhai"'
Autor:
James Ahodantin, Kouki Nio, Masaya Funaki, Xuguang Zhai, Eleanor Wilson, Shyamasundaran Kottilil, Liang Cheng, Guangming Li, Lishan Su
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Liver diseases have become a major comorbidity health concern for people living with HIV-1 (PLWH) treated with combination antiretroviral therapy (cART). To investigate if HIV-1 infection and cART interact to lead to liver diseases, humanized mice re
Externí odkaz:
https://doaj.org/article/266652df0ec6405d9827f03d1055a1d2
Autor:
Wei Guan, Xin Jia, Shengyan Su, Haimeng Tian, Xiaofei Zhu, Yajun Zhou, Xuguang Zhai, Fangyun Cheng
Publikováno v:
The FASEB Journal. 34:5578-5589
Most obese patients develop hyperleptinaemia. Leptin, mainly produced by adipocytes, demonstrates a promotional role in liver fibrosis. Hepatic stellate cell (HSC) activation, a key step in liver fibrogenesis, requires global reprogramming of gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938b9b0eecd2ec4a362ab3c3861a46bb
https://doi.org/10.1096/fj.201903021rr
https://doi.org/10.1096/fj.201903021rr
Publikováno v:
Toxicology and Applied Pharmacology. 339:143-150
Adipocytokine leptin promotes hepatic stellate cell (HSC) activation (a key step in liver fibrogenesis) and liver fibrosis. microRNA-122 (miR-122) is the most abundant liver-specific miRNA and was demonstrated to inhibit liver fibrosis and reduced HS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99eeefeb60dcb5a365c32c2c5ca98db
https://doi.org/10.1016/j.taap.2017.12.007
https://doi.org/10.1016/j.taap.2017.12.007
Autor:
Yali Zhang, Xiaofei Zhu, Yajun Zhou, Xuguang Zhai, Fangyun Cheng, Qian Zhou, Wei Guan, Li Ji, Qing Cao, Xin Jia
Publikováno v:
Molecular Immunology. 92:68-75
Obese patients, often accompanied by hyperleptinemia, are more likely to develop liver fibrosis. Leptin, an adipocyte-derived hormone, augments inflammatory in liver and promotes hepatic stellate cell (HSC) activation (a key step for liver fibrogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f0a959e48f4f63d925de94325c99d9
https://doi.org/10.1016/j.molimm.2017.10.006
https://doi.org/10.1016/j.molimm.2017.10.006
Publikováno v:
Natural Product Research. 32:782-787
20(R)-panaxadiol (PD) was metabolised by the fungus Aspergillus niger AS 3.3926 to its C-3 carbonylated metabolite and five other hydroxylated metabolites (1–6). Their structures were elucidated as 3-oxo-20(R)-panaxadiol (1), 3-oxo-7β-hydroxyl- 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b06f422075a514c241ba57d0b40963
https://doi.org/10.1080/14786419.2017.1360887
https://doi.org/10.1080/14786419.2017.1360887
Autor:
Guangtong Chen, Yan Song, Sensen Yan, Juanjuan Wu, Jie Li, Haijun Lin, Li Jianlin, Xuguang Zhai
Publikováno v:
Phytochemistry Letters. 19:89-93
Microbial transformation of 20( R )-panaxatriol (PT) was performed by using the fungus Aspergillus niger AS 3.739. Six metabolites ( 1 – 6 ) including five new compounds were obtained. The chemical structures of these transformed products were eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d651b48afdf8a4964b7cc7f8f6ebedf
https://doi.org/10.1016/j.phytol.2016.12.012
https://doi.org/10.1016/j.phytol.2016.12.012
Publikováno v:
SSRN Electronic Journal.
The persistence of aberrant inflammation and HIV-1 reservoir cells in patients under effective combination antiretroviral therapy (cART) leads to elevated inflammatory diseases and life-long HIV-1 persistence. Plasmacytoid dendritic cells (pDCs) prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1f38a4c7a3ace971d857d5c83ce2a7c
https://doi.org/10.2139/ssrn.3471314
https://doi.org/10.2139/ssrn.3471314
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 123:154-159
The microbial transformation of 20( R )-panaxadiol ( 1 ) by Absidia corymbifera AS 3.3387 was investigated. Seven oxidized and hydroxylated products 20( R ),25-epoxy-12β-hydroxydammaran- 3-one ( 2 ), 20( R ),25-epoxy-7β,12β,24α-trihydroxydammaran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b04fd0ac65e89b7c29e938b94d491c9c
https://doi.org/10.1016/j.molcatb.2015.11.015
https://doi.org/10.1016/j.molcatb.2015.11.015
Publikováno v:
European Journal of Pharmacology. 746:56-62
Curcumin exerts an inhibitory effect on hepatic stellate cell (HSC) activation, a key step for liver fibrogenesis, and on liver fibrosis by up-regulation of peroxisome proliferator-activated receptor-γ (PPARγ) expression. PPARγ plays a crucial rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594566064323194ee726ae4527622578
https://doi.org/10.1016/j.ejphar.2014.10.055
https://doi.org/10.1016/j.ejphar.2014.10.055
Publikováno v:
Journal of Asian natural products research. 20(8)
The microbial transformation of 20(R)-panaxadiol (PD) by the fungus Absidia coerulea AS 3.3382 afforded three new and three known metabolites. The structures of the metabolites were characterized as 3-oxo-20(R)-panaxadiol (1), 3-oxo-7β- hydroxyl-20(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43af030d30647dfa04397209cf410e76
https://pubmed.ncbi.nlm.nih.gov/28944684
https://pubmed.ncbi.nlm.nih.gov/28944684