Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Xuguang Tai"'
Autor:
Xuguang Tai, Alfred Singer
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 2, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/6ce5d04c3b6e46c5b7f62bcf03a46b23
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b5146e7430664171bdfe613841cbeb6a
Autor:
Praveen Prakhar, Jaylene Alvarez-DelValle, Hilary Keller, Assiatu Crossman, Xuguang Tai, Yoo Kyoung Park, Jung-Hyun Park
Publikováno v:
JCI Insight, Vol 6, Iss 21 (2021)
Foxp3+ Tregs are potent immunosuppressive CD4+ T cells that are critical to maintain immune quiescence and prevent autoimmunity. Both the generation and maintenance of Foxp3+ Tregs depend on the cytokine IL-2. Hence, the expression of the IL-2 recept
Externí odkaz:
https://doaj.org/article/39d57058e50c4456b7e8dac266f6cb2d
Autor:
Adam T. Waickman, Hilary R. Keller, Tae-Hyoun Kim, Megan A. Luckey, Xuguang Tai, Changwan Hong, Carmen Molina-París, Scott T.R. Walsh, Jung-Hyun Park
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101421- (2020)
Summary: IL-7 receptor signaling is essential for the generation and maintenance of conventional T cells. Immunosuppressive Foxp3+ Treg cells, however, express uniquely low amounts of the IL-7-proprietary IL-7Rα so that they are impaired in IL-7 sig
Externí odkaz:
https://doaj.org/article/e0180d3cb2da4b679fb75a7e8a44ace5
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7
Autor:
Anne Gegonne, Qing-Rong Chen, Anup Dey, Ruth Etzensperger, Xuguang Tai, Alfred Singer, Daoud Meerzaman, Keiko Ozato, Dinah S. Singer
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 117-129 (2018)
Summary: T cell differentiation in the thymus proceeds in an ordered sequence of developmental events characterized by variable expression of CD4 and CD8 coreceptors. Here, we report that immature single-positive (ISP) thymocytes are molecularly dist
Externí odkaz:
https://doaj.org/article/69f3e19e9a5c4397a55ab00523c4b6eb
Autor:
Karen S Hathcock, Lila Farrington, Irina Ivanova, Ferenc Livak, Roza Selimyan, Ranjan Sen, Joy Williams, Xuguang Tai, Richard J Hodes
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20639 (2011)
T cell development occurs in the thymus and is critically dependent on productive TCRβ rearrangement and pre-TCR expression in DN3 cells. The requirement for pre-TCR expression results in the arrest of thymocytes at the DN3 stage (β checkpoint), wh
Externí odkaz:
https://doaj.org/article/249b9fedd00d485e85240b65e0a4f66b
Autor:
Xuguang Tai, Alyssa Indart, Mirelle Rojano, Jie Guo, Nicolai Apenes, Tejas Kadakia, Marco Craveiro, Amala Alag, Ruth Etzensperger, Mohamed Elsherif Badr, Flora Zhang, Zhongmei Zhang, Jie Mu, Terry Guinter, Assiatu Crossman, Larry Granger, Susan Sharrow, Xuyu Zhou, Alfred Singer
Publikováno v:
Nature Immunology. 24:637-651
Thymocytes bearing autoreactive T cell receptors (TCRs) are agonist-signaled by TCR/co-stimulatory molecules to either undergo clonal deletion or to differentiate into specialized regulatory T (Treg) or effector T (Teff) CD4+ cells. How these differe
Publikováno v:
Science; 11/3/2023, Vol. 382 Issue 6670, p534-541, 8p, 1 Color Photograph, 4 Diagrams
Autor:
Jaylene Alvarez-DelValle, Hilary R. Keller, Xuguang Tai, Assiatu Crossman, Praveen Prakhar, Yoo Kyoung Park, Jung-Hyun Park
Publikováno v:
JCI Insight
Foxp3+ Tregs are potent immunosuppressive CD4+ T cells that are critical to maintain immune quiescence and prevent autoimmunity. Both the generation and maintenance of Foxp3+ Tregs depend on the cytokine IL-2. Hence, the expression of the IL-2 recept