Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Xuguang Du"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract During early embryonic development, the transition from totipotency to pluripotency is a fundamental and critical process for proper development. However, the regulatory mechanisms governing this transition remain elusive. Here, we conducted
Externí odkaz:
https://doaj.org/article/edeaeead06b042fe91676bca65fb1b53
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Various methods for ex utero culture systems have been explored. However, limitations remain regarding the in vitro culture platforms used before implanting mouse embryos and the normal development of mouse blastocysts in vitro. F
Externí odkaz:
https://doaj.org/article/83716d36c9d74048b5e86699ca449f96
Autor:
Gaochuang Peng, Tianran Liu, Xiaolan Qi, Yuzhe Wang, Jingjing Ren, Jiangling Peng, Xuguang Du, Siyu Hu, Sen Wu, Yaofeng Zhao, Dan Li, Haixue Zheng
Publikováno v:
PLoS Pathogens, Vol 20, Iss 3, p e1012104 (2024)
The interaction between foot-and-mouth disease virus (FMDV) and the host is extremely important for virus infection, but there are few researches on it, which is not conducive to vaccine development and FMD control. In this study, we designed a porci
Externí odkaz:
https://doaj.org/article/0314621e861c433c969db32c3e26146a
Autor:
Yumin Qin, Chongyang Li, Xin Gao, Yuanyuan Wu, Zihang Guo, Fei Gao, Dawei Yu, Sen Wu, Xuguang Du
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/9e3560ea2450441793e7dee66b7a6a3b
Autor:
Yan Li, Di Lian, Jiahao Wang, Yue Zhao, Yao Li, Guoshi Liu, Sen Wu, Shoulong Deng, Xuguang Du, Zhengxing Lian
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 309-323 (2023)
CRISPR-Cas9-mediated genome editing in sheep is of great use in both agricultural and biomedical applications. While targeted gene knockout by CRISPR-Cas9 through non-homologous end joining (NHEJ) has worked efficiently, the knockin efficiency via ho
Externí odkaz:
https://doaj.org/article/8f682be0ecd34f758d807b5ab1b8f118
Autor:
Menghao You, Jingjing Liu, Jie Li, Ce Ji, Haochen Ni, Wenhui Guo, Jiarui Zhang, Weiwei Jia, Zhao Wang, Yajiao Zhang, Yingpeng Yao, Guotao Yu, Huanyu Ji, Xiaohu Wang, Dali Han, Xuguang Du, Meng Michelle Xu, Shuyang Yu
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112584- (2023)
Summary: N6-methyladenosine (m6A) methyltransferase Mettl3 is involved in conventional T cell immunity; however, its role in innate immune cells remains largely unknown. Here, we show that Mettl3 intrinsically regulates invariant natural killer T (iN
Externí odkaz:
https://doaj.org/article/1731facf070d4ff49f8cb7c4d12e9664
Publikováno v:
Animal Models and Experimental Medicine, Vol 5, Iss 2, Pp 141-152 (2022)
Abstract Animal models of human diseases play a critical role in medical research. Pigs are anatomically and physiologically more like humans than are small rodents such as mice, making pigs an attractive option for modeling human diseases. Advances
Externí odkaz:
https://doaj.org/article/93847c90997d4fa98d8d941815274582
Autor:
Xuguang Du, Zihang Guo, Wenhui Fan, Tang Hai, Fei Gao, Pan Li, Yumin Qin, Chaolei Chen, Zhiqiang Han, Jilong Ren, Pengtao Jiao, Wenjun Liu, Yuhai Bi, Dawei Yu, Sen Wu
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-4 (2021)
Externí odkaz:
https://doaj.org/article/8de19c4ae8544b91bb83b3a48f82c81b
Autor:
Bingbo Shi, Dengfeng Gao, Liang Zhong, Minglei Zhi, Xiaogang Weng, Junjun Xu, Junhong Li, Xuguang Du, Yanli Xin, Jie Gao, Qianqian Zhu, Suying Cao, Zhonghua Liu, Jianyong Han
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-19 (2020)
Abstract Background Despite years of research, porcine-induced pluripotent stem cells (piPSCs) with germline chimeric capacity have not been established. Furthermore, the key transcription factors (TFs) defining the naïve state in piPSCs also remain
Externí odkaz:
https://doaj.org/article/7e3a69b8efa545b59faf3658e9a95c4e
Autor:
Junjun Xu, Zheng Zheng, Xuguang Du, Bingbo Shi, Jichang Wang, Dengfeng Gao, Qianqian Zhu, Xinze Chen, Jianyong Han
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2020)
Abstract Background NANOG functions as the gateway for the generation of pluripotent stem cells (PSCs) in mice and humans. NANOG is a transcription factor highly expressed in pig pre-implantation embryos, indicating that it is a conserved pluripotenc
Externí odkaz:
https://doaj.org/article/136f19305c1342c99e46d8ec9388b1fd