Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Autor: Aleksei Kabedev, Xuezhi Zhuo, Donglei Leng, Vito Foderà, Min Zhao, Per Larsson, Christel A. S. Bergström, Korbinian Löbmann

Publikováno v: Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing mechanisms of β-lactoglobulin in amorphous solid dispersions of indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922-3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397
Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922–3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397

Proteins, and in particular whey proteins, have recently been introduced as a promising excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of the approach, the molecular mechanisms behind the stabilization of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde64920fa1849af9775aa78cee253cc
https://doi.org/10.1021/acs.molpharmaceut.2c00397

A parenteral docetaxel-loaded lipid microsphere with decreased 7-epidocetaxel conversion in vitro and in vivo

Autor: Lu Liu, Haibing He, Qiuyue Chen, Xiuzhi Wang, Tian Yin, Lifeng Luo, Xing Tang, Linlin Miao, Yu Zhang, Xuezhi Zhuo, Jiawen Xu

Publikováno v: European Journal of Pharmaceutical Sciences. 109:638-649

The purpose of the study was to develop a parenteral docetaxel lipid microsphere to inhibit its 7-epidocetaxel conversion in vitro and in vivo. 7-epidocetaxel conversion as the main indicator was investigated to optimize the formulation and process.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afedc2027a58a469c5acff99e275d2f4
https://doi.org/10.1016/j.ejps.2017.09.022

Modified PLGA–PEG–PLGA thermosensitive hydrogels with suitable thermosensitivity and properties for use in a drug delivery system

Autor: Jingxin Gou, Haibing He, Xing Tang, Xuezhi Zhuo, Tianyang Ren, Wei Chu, Puxiu Wang, Tian Yin, Yu Zhang

Publikováno v: Journal of Materials Chemistry B. 5:1551-1565

PLGA-PEG-PLGA (PPP) triblock copolymer is the most widely studied thermosensitive hydrogel owing to its non-toxic, biocompatible, biodegradable, and thermosensitive properties. PPP thermosensitive hydrogels are being investigated as in situ gels beca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732854b093e43c7c2dbc717851b052a9
https://doi.org/10.1039/c6tb02158a

mPEG

Autor: Linlin, Miao, Jia, Su, Xuezhi, Zhuo, Lifeng, Luo, Yihan, Kong, Jingxin, Gou, Tian, Yin, Yu, Zhang, Haibing, He, Xing, Tang

Publikováno v: Molecular pharmaceutics. 15(4)

The clinical application of disulfiram (DSF) in cancer treatments is hindered by its rapid degradation in the blood circulation. In this study, methoxy poly(ethylene glycol)- b-poly(lactide- co-glycolide)/poly(ε-caprolactone) (mPEG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::191b1981d9ad19e521d8124687e4f106
https://pubmed.ncbi.nlm.nih.gov/29505711

A Comparative Study between A Protein Based Amorphous Formulation and Other Dissolution Rate Enhancing Approaches: A Case Study with Rifaximin.

Autor: Zhuo, Xuezhi¹ (AUTHOR), Margrethe Brekstad Kjellin, Maud¹ (AUTHOR), Schaal, Zarah¹ (AUTHOR), Zhang, Tengyu¹ (AUTHOR), Löbmann, Korbinian^1,2 (AUTHOR), Leng, Donglei² (AUTHOR) dl@zerion.eu

Publikováno v: Pharmaceutics. Jan2023, Vol. 15 Issue 1, p126. 10p.