Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Xueying Ruan"'
Autor:
Carl He Ren, Christopher Bohm, Xueying Ruan, Gerold Schmitt-Ulms, Seema Qamar, Keith T. Ho, Paul E. Fraser, Amy Hye Won Jeon, Fusheng Chen, Paul M. Mathews, Howard T.J. Mount, Peter St George-Hyslop, Hairu Huo
Publikováno v:
The Journal of Biological Chemistry
Background: The human genome codes for two presenilin (PS) paralogs, PS1 and PS2. Results: PS paralogs are embedded in overlapping but distinct molecular environments, with signal peptide peptidase (SPP) primarily binding to PS2. Conclusion: Study pa
Autor:
Gerold Schmitt-Ulms, Hiroshi Hasegawa, Kirk C. Hansen, Nobuo Sanjo, Christopher Bohm, Toshitaka Kawarai, David Westaway, Paul E. Fraser, Ekaterina Rogaeva, Yongjun Gu, Michael Glista, Anurag Tandon, Philippe Marambaud, Yosuke Wakutani, Peter St George-Hyslop, Taiichi Katayama, Raphaëlle Pardossi-Piquard, Xueying Ruan, Frédéric Checler, Fusheng Chen
Publikováno v:
Nature. 440:1208-1212
The presenilin proteins (PS1 and PS2) and their interacting partners nicastrin, aph-1 (refs 4, 5) and pen-2 (ref. 5) form a series of high-molecular-mass, membrane-bound protein complexes that are necessary for gamma-secretase and epsilon-secretase c
Autor:
Peter St George-Hyslop, Howard T.J. Mount, Linda Wang, Xueying Ruan, Nobuo Sanjo, Bruce A. Yankner, Paul E. Fraser, Shigeki Arawaka, Fusheng Chen, Anurag Tandon, David Westaway, Hiroshi Hasegawa, Serap Erdebil, Peter Mastrangelo, Frank S. Lee, Yongjun Gu
Publikováno v:
Journal of Biological Chemistry. 278:19974-19979
The presenilins and nicastrin form high molecular mass, multimeric protein complexes involved in the intramembranous proteolysis of several proteins. Post-translational glycosylation and trafficking of nicastrin is necessary for the activity of these
Autor:
Gerold Schmitt-Ulms, Peter St George-Hyslop, Kirk Hansen, Taiichi Katayama, Michael Glista, Anurag Tandon, Yongju Gu, Paul E. Fraser, Raphaelle Pardossi Piquard, Xueying Ruan, Nobuo Sanjo, Fusheng Chen, Yosuke Wakutani, David Westaway, Ekaterina Rogaeva, Hiroshi Hasegawa, Philippe Marambaud, Frédéric Checler, Christopher Bohm, Toshitaka Kawarai
Publikováno v:
Alzheimer's & Dementia. 2
Autor:
Fusheng, Chen, Hiroshi, Hasegawa, Gerold, Schmitt-Ulms, Toshitaka, Kawarai, Christopher, Bohm, Taiichi, Katayama, Yongjun, Gu, Nobuo, Sanjo, Michael, Glista, Ekaterina, Rogaeva, Yosuke, Wakutani, Raphaëlle, Pardossi-Piquard, Xueying, Ruan, Anurag, Tandon, Frédéric, Checler, Philippe, Marambaud, Kirk, Hansen, David, Westaway, Peter, St George-Hyslop, Paul, Fraser
Publikováno v:
Nature. 440(7088)
The presenilin proteins (PS1 and PS2) and their interacting partners nicastrin, aph-1 (refs 4, 5) and pen-2 (ref. 5) form a series of high-molecular-mass, membrane-bound protein complexes that are necessary for gamma-secretase and epsilon-secretase c
Autor:
Hiroshi Hasegawa, Agnes Petit, Fusheng Chen, Paul E. Fraser, Toshitaka Kawarai, Peter St George-Hyslop, Xueying Ruan, Yongjun Gu, Nobuo Sanjo, David Westaway, Wenping Li, Cortney Shier, Gerold Schmitt-Ulms
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (30), pp.31329-31336. ⟨10.1074/jbc.M401548200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (30), pp.31329-31336. ⟨10.1074/jbc.M401548200⟩
Several lines of evidence have indicated that the presenilin proteins function within macromolecular complexes and are necessary for the regulated intramembranous proteolysis of certain type 1 transmembrane proteins, including the amyloid precursor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8452eb3b89b54c4bc25bc6a73faa327
https://hal.archives-ouvertes.fr/hal-03016615
https://hal.archives-ouvertes.fr/hal-03016615
Autor:
Toshitaka Kawarai, Howard T.J. Mount, Peter St George-Hyslop, Anurag Tandon, Nobuo Sanjo, Anchla Luthra, Fusheng Chen, Monica Duthie, Paul E. Fraser, Yongjun Gu, Hiroshi Hasegawa, Wenping Li, Xueying Ruan
Publikováno v:
The Journal of biological chemistry. 278(9)
APH-1 and PEN-2 genes modulate the function of nicastrin and the presenilins in Caenorhabditis elegans. Preliminary studies in transfected mammalian cells overexpressing tagged APH-1 proteins suggest that this genetic interaction is mediated by a dir
Autor:
Paul E. Fraser, Fusheng Chen, Shigeki Arawaka, Peter St George-Hyslop, Hiroshi Hasegawa, David Westaway, Yongjun Gu, Xueying Ruan, Howard T.J. Mount
Publikováno v:
The Journal of biological chemistry. 277(39)
The presenilin 1 (PS1) and presenilin 2 (PS2) proteins are necessary for proteolytic cleavage of the amyloid precursor protein (APP) within its transmembrane domain. One of these cleavage events (termed gamma-secretase) generates the C-terminal end o
Autor:
Fusheng Chen, Hasegawa, Hiroshi, Schmitt-Ulms, Gerold, Kawarai, Toshitaka, Bohm, Christopher, Katayama, Taiichi, Yongjun Gu, Sanjo, Nobuo, Glista, Michael, Rogaeva, Ekaterina, Wakutani, Yosuke, Pardossi-Piquard, Raphaëlle, Xueying Ruan, Tandon, Anurag, Checler, Frédéric, Marambaud, Philippe, Hansen, Kirk, Westaway, David, St. George-Hyslop, Peter, Fraser, Paul
Publikováno v:
Nature; 4/27/2006, Vol. 440 Issue 7088, p1208-1212, 5p, 4 Diagrams
Autor:
Amy Hye Won Jeon1, Böhm, Christopher1, Fusheng Chen1, Hairu Huo1, Xueying Ruan1, Carl He Ren1, Keith Ho1, Qamar, Seema2, Mathews, Paul M.3, Fraser, Paul E.1, Mount, Howard T. J.1, St. George-Hyslop, Peter1,2, Schmitt-Ulms, Gerold1 g.schmittulms@utoronto.ca
Publikováno v:
Journal of Biological Chemistry. 5/24/2013, Vol. 288 Issue 21, p15352-15366. 15p.