Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Xueyi Shen"'
Autor:
Rosie M. Walker, Michael Chong, Nicolas Perrot, Marie Pigeyre, Danni A. Gadd, Aleks Stolicyn, Liu Shi, Archie Campbell, Xueyi Shen, Heather C. Whalley, Alejo Nevado-Holgado, Andrew M. McIntosh, Stefan Heitmeier, Sumathy Rangarajan, Martin O’Donnell, Eric E. Smith, Salim Yusuf, William N. Whiteley, Guillaume Paré
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we ass
Externí odkaz:
https://doaj.org/article/edaf7fb177e34492a3507cce3b3d3eea
Autor:
Maria Viejo-Romero, Heather C Whalley, Xueyi Shen, Aleks Stolicyn, Daniel J Smith, David M Howard
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0300449 (2024)
Environmental exposures during the perinatal period are known to have a long-term effect on adult physical and mental health. One such influential environmental exposure is the time of year of birth which affects the amount of daylight, nutrients, an
Externí odkaz:
https://doaj.org/article/15ed9a73331d4226a8590ead58117970
Autor:
Chenhao Gao, Carmen Amador, Rosie M. Walker, Archie Campbell, Rebecca A. Madden, Mark J. Adams, Xiaomeng Bai, Ying Liu, Miaoxin Li, Caroline Hayward, David J. Porteous, Xueyi Shen, Kathryn L. Evans, Chris S. Haley, Andrew M. McIntosh, Pau Navarro, Yanni Zeng
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Background The variation in the rate at which humans age may be rooted in early events acting through the genomic regions that are influenced by such events and subsequently are related to health phenotypes in later life. The parent-of-origi
Externí odkaz:
https://doaj.org/article/b78a5a466ff14b5192c67c87ae1821d6
Autor:
Miruna Carmen Barbu, Mat Harris, Xueyi Shen, Stolicyn Aleks, Claire Green, Carmen Amador, Rosie Walker, Stewart Morris, Mark Adams, Anca Sandu, Christopher McNeil, Gordon Waiter, Kathryn Evans, Archie Campbell, Joanna Wardlaw, Douglas Steele, Alison Murray, David Porteous, Andrew McIntosh, Heather Whalley
Publikováno v:
Epigenetics, Vol 17, Iss 10, Pp 1143-1158 (2022)
A complex interplay of genetic and environmental risk factors influence global brain structural alterations associated with brain health and disease. Epigenome-wide association studies (EWAS) of global brain imaging phenotypes have the potential to r
Externí odkaz:
https://doaj.org/article/978f5a01b1fb4c6ab7e569804eabbec4
Autor:
Niamh MacSweeney, Judith Allardyce, Amelia Edmondson-Stait, Xueyi Shen, Hannah Casey, Stella W.Y. Chan, Breda Cullen, Rebecca M. Reynolds, Sophia Frangou, Alex S.F. Kwong, Stephen M. Lawrie, Liana Romaniuk, Heather C. Whalley
Publikováno v:
Developmental Cognitive Neuroscience, Vol 60, Iss , Pp 101223- (2023)
Background: Earlier pubertal timing is associated with higher rates of depressive disorders in adolescence. Neuroimaging studies report brain structural associations with both pubertal timing and depression. However, whether brain structure mediates
Externí odkaz:
https://doaj.org/article/90bd096d94294c89b7c408528f84bd50
Autor:
Mathew A. Harris, Simon R. Cox, Laura de Nooij, Miruna C. Barbu, Mark J. Adams, Xueyi Shen, Ian J. Deary, Stephen M. Lawrie, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Depression is assessed in various ways in research, with large population studies often relying on minimal phenotyping. Genetic results suggest clinical diagnoses and self-report measures of depression show some core similarities, but also i
Externí odkaz:
https://doaj.org/article/aab0a5a9ff184c02856fc613af0c3079
Autor:
Xueyi Shen, Doretta Caramaschi, Mark J. Adams, Rosie M. Walker, Josine L. Min, Alex Kwong, Gibran Hemani, Genetics of DNA Methylation Consortium, Miruna C. Barbu, Heather C. Whalley, Sarah E. Harris, Ian J. Deary, Stewart W. Morris, Simon R. Cox, Caroline L. Relton, Riccardo E. Marioni, Kathryn L. Evans, Andrew M. McIntosh
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation but the association
Externí odkaz:
https://doaj.org/article/d2acf3cdcee6403f88223fb30ff43ea6
Autor:
Rebecca A. Madden, Kimberley Atkinson, Xueyi Shen, Claire Green, Robert F. Hillary, Emma Hawkins, Emma Såge, Anca-Larisa Sandu, Gordon Waiter, Christopher McNeil, Mathew Harris, Archie Campbell, David Porteous, Jennifer A. Macfarlane, Alison Murray, Douglas Steele, Liana Romaniuk, Stephen M. Lawrie, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
European Psychiatry, Vol 66 (2023)
Abstract Introduction Childhood trauma and adversity are common across societies and have strong associations with physical and psychiatric morbidity throughout the life-course. One possible mechanism through which childhood trauma may predispose in
Externí odkaz:
https://doaj.org/article/fd57a95524dd4b0cbc18d0a10997de82
Autor:
Amelia J. Edmondson-Stait, Xueyi Shen, Mark J. Adams, Miruna C. Barbu, Hannah J. Jones, Veronique E. Miron, Judith Allardyce, James P. Boardman, Stephen M. Lawrie, Andrew M. McIntosh, Golam M. Khandaker, Alex S.F. Kwong, Heather C. Whalley
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 26, Iss , Pp 100528- (2022)
Inflammation is implicated in depression and psychosis, including association of childhood inflammatory markers on the subsequent risk of developing symptoms. However, it is unknown whether early-life inflammatory markers are associated with the numb
Externí odkaz:
https://doaj.org/article/f88a130972c04c3db498c86226a54915
Autor:
Claire Green, Aleks Stolicyn, Mathew A. Harris, Xueyi Shen, Liana Romaniuk, Miruna C. Barbu, Emma L. Hawkins, Joanna M. Wardlaw, J. Douglas Steele, Gordon D. Waiter, Anca-Larisa Sandu, Archie Campbell, David J. Porteous, Jonathan R. Seckl, Stephen M. Lawrie, Rebecca M. Reynolds, Jonathan Cavanagh, Andrew M. McIntosh, Heather C. Whalley
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of results; potentially due to the predominant use of acute measures of an inheren
Externí odkaz:
https://doaj.org/article/89b054256ca14047ae3a738743e18a0d